DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10353 and Ano6

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_008763957.1	Gene:	Ano6 / 315272	RGDID:	1304765	Length:	932	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	330/882 - (37%)
Similarity:	500/882 - (56%)	Gaps:	107/882 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAYNGETQL--------EEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKI 236
            |.||:|.:||||.|..|::.        |:.:||.:.:|:||...|||||..:.   .::.|:|:
  Rat    85 FTDGQRRIDFVLVYEDESKKENNKKGTNEKQKRKRQAYESNLISHGLQLEATRSVSDDKLVFVKV 149

  Fly   237 HAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSS-------VQLNTAL 294
            |||.|||..||||:.||:||||            ::.||      :|.|.:       :::|.::
  Rat   150 HAPWEVLCTYAEIMHIKLPLKP------------NDLKT------RSTFDTFNWFTKVLRVNESV 196

  Fly   295 FPEREPRIHLEFSRNYL-ELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQD 358
            ....:......|.::.: :.|..:..:|.:.:||..|:.|||.|.:: :.....:..||.:||..
  Rat   197 IKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKY-QVMNNVNKFGINRLVSS 260

  Fly   359 GVYTCAYTLHD------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLG 411
            |:|..|:.|||            ..:|..|.:|||:.......||||.|:.|:|.|:.:||||||
  Rat   261 GIYKAAFPLHDCKFNYKSEDPNCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLG 325

  Fly   412 FYTQMLIPISVFGVLCFLYGFITWNSDPISRDICD-DNG--TIMCPQCDRSCDYWRLNETCTSSK 473
            :|||||:..:|.||.|||||::..::...|:::|| |.|  .:|||||||.|.:||||.||.|||
  Rat   326 YYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSK 390

  Fly   474 FNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKL 538
            ...:.|:..|::||..|.:|..::||||||..|.|.:.|. |......|.|||:|.|:.:..  :
  Rat   391 KLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWD-TVELQQEEQPRPEYEAQCNHV--V 452

  Fly   539 AGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA-IAGIIIYRMAQRASHSI 602
            ..:..:::..         :||.:.......|..:..|.|..:.:|| :.|||:||::.....|.
  Rat   453 INEITQEEER---------IPFTTCGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFST 508

  Fly   603 L------GSENSMTFKV--MILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLT 659
            .      |::....:..  |...:||.||..|:|.:|:.:|..:|:.:||:|..||||:|:.|||
  Rat   509 TLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLT 573

  Fly   660 IKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAGKQ 723
            :|.::|||||||||.|||||.||||||||......|| :|.|||:|||||:||..||.|||.||.
  Rat   574 MKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA 638

  Fly   724 AVNAIVEMLIPYLMRTFKELSYRHGWYKS-HQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVV 787
            ..|.|.|:|:|::|...       |.||. ...:::.|  ::.:||:|.|.....|:.|||||::
  Rat   639 IWNNIQEVLLPWVMNLI-------GRYKRVSGSEKITP--RWEQDYHLQPMGRLGLFYEYLEMII 694

  Fly   788 QFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVA 852
            ||||:|||..:|||||||||:||::|:|:||.|:....||.|..:|:|||.|..||..:..:||.
  Rat   695 QFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVV 759

  Fly   853 SSAMIIAFSTNLIPKIVYAASMGDP--------ELNNYLNFTLAVFNTKDF----QVQPLLGGSQ 905
            ::||||||::::||::||..|...|        .::.|:|.||:|||..||    :..|.:|..
  Rat   760 TNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLG- 823

  Fly   906 HVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLL 970
              |.|:|||.:|||.|..|..||..:.||.::..:||||::.:::|..::..:.:|:||||....
  Rat   824 --NYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKITK 886

  Fly   971 KRIKRENFLLRE-----HIIEYEKQHAMKLVQTELNG 1002
            .:||||.:|.::     |:.:..|.  |.|:...:.|
  Rat   887 SKIKREKYLTQKLLHESHLKDLTKN--MGLIAERIGG 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	70/239 (29%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	250/607 (41%)
Ano6	XP_008763957.1	Anoct_dimer	84..306	CDD:292796	70/239 (29%)
Ano6	XP_008763957.1	Anoctamin	309..893	CDD:282414	250/607 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820