DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and Ano3

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_038962388.1	Gene:	Ano3 / 311287	RGDID:	1308873	Length:	981	Species:	Rattus norvegicus

Alignment Length:	879	Identity:	311/879 - (35%)
Similarity:	470/879 - (53%)	Gaps:	113/879 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAYNGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKIHAPAEVLY 244
            |.|||:.:|::|.|. :|.::..:|  ..||.||:.|||.||....   ..:.|||:|.|.:.|.
  Rat   157 FKDGKKRIDYILVYR-KTNIQYDKR--NTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLC 218

  Fly   245 RYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSS-VQLNTALFPERE--------- 299
            :|||.|.|:||.:..........:|....:..|.|:.|.:..: :.|:.:.|||.|
  Rat   219 KYAERLNIRVPFRKKCYYTDQKNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPF 283

  Fly   300 --PRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYT 362
              .|||.....|    .||    |...:||..|:..:|:|.::..|   ...:||.||:.:|.|.
  Rat   284 SRARIHHFIINN----KDT----FFSNATRSRIVYHMLERTKYENG---ISKVGIRKLINNGSYI 337

  Fly   363 CAYTLHD--------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFY 413
            .|:..|:              :::|..|.:.||....|...||||.|:.|||.|:.|||||||:|
  Rat   338 AAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWY 402

  Fly   414 TQMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLI 478
            |.||||.:|.|:..|.||.:|.|...:|::||......|||.||::|...|||::|..:|..||.
  Rat   403 TGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLF 467

  Fly   479 DNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAY 543
            ||..||.||..|||||.|:||||||..:.|.:.|.|..:....|..|||:.|:..|.:.:
  Rat   468 DNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEII----- 527

  Fly   544 EQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENS 608
             ...|||.   :|..|. |.|......|.|.:...|.:.:.|:..:::||        ::..|..
  Rat   528 -NPITGKP---EPHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYR--------LVVMEQF 579

  Fly   609 MTFKVMILPM-----TAG---IIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVF 665
            .:||...:..     |:|   .|:.|:|.||::.|..:|..|||.||.||::|::.|..:|.::|
  Rat   580 ASFKWNFIKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLF 644

  Fly   666 QFVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIV 729
            ||||..||:|||||..|:|||:|.|||::. .:|.|||:|.|||::||:|:.:||..||..|..:
  Rat   645 QFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFM 709

  Fly   730 EMLIPYLMRTFKELSYRHGWYKSHQDQR-----LVPYNQFTEDYNLLPAENNSLYVEYLEMVVQF 789
            |:..|.:          ..|:..|:.:|     .:|  |:..|:||.|...:.|..||||||:||
  Rat   710 ELGYPLI----------QNWWSRHKIKRGIQDASIP--QWENDWNLQPMNIHGLMDEYLEMVLQF 762

  Fly   790 GFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASS 854
            ||.|:|..|||||||||||||:||:||||.|.:...|||:..||.|||:|..|:..:..:||.::
  Rat   763 GFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITN 827

  Fly   855 AMIIAFSTNLIPKIVYAASMG---------DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNET 910
            |.:||.:::.||:.||....|         :..|..|:|.:|:.|:..:..:    |.|.:
  Rat   828 AFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGI----GKSGY---- 884

  Fly   911 VCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKR 975
             |||.::|..|....||:..:.||.||..|||||:::::::..::..:.:.:||:...|.:||:|
  Rat   885 -CRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRR 948

  Fly   976 ENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGE 1009
            |.:|::|.:.|.|.:|        |..|::..|:
  Rat   949 EKYLVQEMMYEAELEH--------LQQQRRKSGQ 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	67/237 (28%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	232/604 (38%)
Ano3	XP_038962388.1	Anoct_dimer	157..381	CDD:406563	67/237 (28%)
Ano3	XP_038962388.1	Anoctamin	384..949	CDD:398306	231/603 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920