DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10353 and Ano5

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_006229328.1	Gene:	Ano5 / 308637	RGDID:	1564265	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	312/882 - (35%)
Similarity:	480/882 - (54%)	Gaps:	115/882 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAY------NGETQLEEHRRKCEIFEANLQREGLQLE-----HNKVQRVHFIKI 236
            |.||.|.:||||:|      :||  |:..||  :.||.||::.||:||     :::..:.:|:||
  Rat   412 FRDGIRQIDFVLSYVEDVKKDGE--LKAERR--QTFEQNLRKTGLELEIEDKMNSEDGKTYFVKI 472

  Fly   237 HAPAEVLYRYAEILKIKVPLK----PIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTAL-FP 296
            |||.|||..|||:|.||:|:|    |.|....:                ..:...|:|...: :|
  Rat   473 HAPWEVLVTYAEVLGIKMPIKLSDIPRPKYSPL----------------SYMLGPVKLPLGVKYP 521

  Fly   297 EREPRIHLEFSRNYLELYDTE-HPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGV 360
            :.| ....:|||:..||:..| ...|..:|||..|:.:||.|..|.| ||....:|||:|:....
  Rat   522 KPE-YFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGE-EEGKKKIGIERLLNTNT 584

  Fly   361 YTCAYTLHDK-----------DDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYT 414
            |..||.|||.           ::|..|.|.||..|.:...||.|.|::|:|.|:.:||.:||:||
  Rat   585 YLSAYPLHDGQYWRPSKTSRINERYVLCKNWARFSYFYKEQPFDLIRNYYGEKIGIYFVFLGYYT 649

  Fly   415 QMLIPISVFGVLCFLYGFITWNSDPISRDICDDN---GTIMCPQCDRSCDYWRLNETCTSSKFNY 476
            :||:..::.|:.||:||.::..|:..|.:|||.|   ..||||.||..|||||||.||..|||::
  Rat   650 EMLLFAALVGLACFIYGLLSMESNQTSIEICDPNIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSH 714

  Fly   477 LIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVE--HPRPQYLARISRTKKLA 539
            |.||..||.||..|.||..::|||||:..|.|.:.|.|..|....:  ..||::.| :.:.||:.
  Rat   715 LFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEA-MCKHKKMN 778

  Fly   540 GKAYEQDHTGKRTILDPDVPF-----WSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRAS 599
            ....|         ::|.:|.     |      .|.|.:.:...:.:.:.::..||:||::..|.
  Rat   779 PVTQE---------MEPHMPLCHRIPW------YFVSGTTVTFGMALLLSSMVSIIVYRLSVFAI 828

  Fly   600 H-SILGSENSM-TFKVMILP-----MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDES 657
            . |.:.||.:: :.|....|     ::|..::.:||.:|:..|..::..:|..|..||..||:.|
  Rat   829 FASFMESEATLQSVKRFFTPQLATALSASCLNCLVILILNFFYEKISAWITKMEIPRTHQEYESS 893

  Fly   658 LTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAG 721
            ||:|.::|||||||||.||:||.||||||||.:|..:.. :|.|||.|.|||:||..||.|||.|
  Rat   894 LTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGRYTYMFNLWRSEECGPPGCLIELTTQLTIIMIG 958

  Fly   722 KQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMV 786
            ||....|.|...|.:...::....|     :|.::.   |:::.:|::|....:..|:.||||.|
  Rat   959 KQIFGNIHEACQPLIFNWWRRRRTR-----THSEKL---YSRWEQDHDLQVYGHRGLFYEYLETV 1015

  Fly   787 VQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAV 851
            :||||:|||..:||||||.||:||::.:|:||.|:....||||..:|..||||..|:..:..::|
  Rat  1016 MQFGFVTLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILYGMAILSV 1080

  Fly   852 ASSAMIIAFSTNLIPKIV--YAASMGDPE-LNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETV-- 911
            |::|.|::|::::||::|  ||.|....| |:.|:|.:|:||...||.           |.||
  Rat  1081 ATNAFIVSFTSDIIPRLVYFYAYSKNSTEPLSGYINNSLSVFLIADFP-----------NHTVPM 1134

  Fly   912 -------CRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRL 969
                   |||.::|..|:....|...|.:|.:|..::.||::.::|:.:.:.:|.|.:|||...:
  Rat  1135 EKKDFVTCRYRDYRYPPDHKGKYGHNMQFWHVLAAKMTFIIVMEHIVFLFKFLLAWMIPDVPKDV 1199

  Fly   970 LKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKS 1006
            .::||||..:..:.|.::|.....:.:..|.....|:
  Rat  1200 AEKIKREKLMTVKIIHDFELNKLKENLDVEYGNIMKN 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	80/236 (34%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	225/611 (37%)
Ano5	XP_006229328.1	MIP-T3	30..>371	CDD:287245
		Anoct_dimer	411..626	CDD:292796	79/235 (34%)
		Anoctamin	630..1207	CDD:282414	225/611 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920