Protein Alignment CG10353 and Ano8

DIOPT Version :9

• Sequence 1: NP_001245633.1
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_038950925.1
• Gene: Ano8 / 306340
• RGDID: 1563946
• Length: 1141
• Species: Rattus norvegicus
• Alignment Length: 1170
• Identity: 241/1170 - (20%)
• Similarity: 383/1170 - (32%)
• Gaps: 462/1170 - (39%)

  Fly   108 GGGDHTDAAIAAQMIALQNGRNHLPTGIGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITY 172
            |.||.|          |:..|...|...|.......|..|....:|||:....:        :::
  Rat     7 GAGDAT----------LEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYL--------VSH 53

  Fly   173 SQWKSRTYRRFDDGKRSVDFVLAYNGETQLEEHRRKCEIFEANLQREGL-----QLEHNKVQRVH 232
            ..| .:|....|     .|.::.:...|  ::|..   ::..|..|.|:     |:.|::..|.:
  Rat    54 KAW-MKTVPTED-----CDVLMTFPDTT--DDHTL---LWLLNHIRVGIPELIVQVRHHRHTRAY 107

  Fly   233 FIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKS--LFSSVQLNTALF 295
            ...:.|..|.|.|.|:.|.::..:|      ..|......|.      |:.  ::.:|:.....|
  Rat   108 AFFVTATYESLLRGADELGLRKAVK------AEFGGGTRSFS------CEEDFIYENVENELRFF 160

  Fly   296 PEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEE------TADNLGIEK 354
            ..:|                           |.|||.|.||..|..:||.      ..|...|.:
  Rat   161 TSQE---------------------------RQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPE 198

  Fly   355 LVQDGVYTCAYTLHDKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIP 419
            |...|:....:.:|::...:||:|.|.. :..:| ||||.|.||||.|:|:|||||||||..::.
  Rat   199 LAARGIIQQVFPVHEQRILNRLMKSWVQ-AVCEN-QPLDDICDYFGVKIAMYFAWLGFYTSAMVY 261

  Fly   420 ISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTV 484
            .:|||.:  ||.|.  .:|..|||:              ||                       |
  Rat   262 PAVFGSV--LYTFT--EADQTSRDV--------------SC-----------------------V 285

  Fly   485 VFAFSMAIWAVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQY--LARISRTKKLAGKAYEQD 546
            |||....||:.::||.|||..|.|.::|| |......||.||||:  :.|||...:.....|
  Rat   286 VFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGIRRISPITRAEEFYY--- 347

  Fly   547 HTGKRTILDPDVPFWS---FKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENS 608
                        |.|.   |:.|     .|:.:...|:..:.:..:..:::.:
  Rat   348 ------------PPWKRLLFQLL-----VSLPLCLACLVCVFVLMLGCFQLQE------------ 383

  Fly   609 MTFKVMILPMTAGIIDLIVISLLDMV----YSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVN 669
            :...|..||.....:..::::||..|    |..|||.|.:.|..|.::.|:..|.||..:|||||
  Rat   384 LVLSVKGLPRLVRFLPKVILALLVSVSAEGYKKLAVWLNDMENYRLESTYERHLIIKVVLFQFVN 448

  Fly   670 YYSSLFYIAF-------------------------------------------LKG--------- 682
            .|.|||||.|                                           |:|
  Rat   449 SYLSLFYIGFYLKDMDRLKELLLLLSLTQSLERQLRAALVPLAALRFRLLLLSLRGLLLVARAKM 513

  Fly   683 --------------KFVGYPAKYNRV----LGFR------------------------------- 698
                          :.|..|..|.|:    ||.|
  Rat   514 LATLLITRQLLQNVREVLQPHLYRRLGSGELGLRTILELARALLGLLNPLRPDPRRHLEAQADEG 578

  Fly   699 ---QEECNPGGC----------------------------------------------------- 707
               ...|..|||
  Rat   579 GAGSRRCLGGGCGAPEEEEEVAVERRPAGEGGEVPEGPRGGKEEDEEEDDDDEDEDEEYEGEEGS 643

  Fly   708 LMELCMQLVIIM-----AGKQAVNAIVEMLIPYLMRTFKELSYRHGWY---KSHQDQRLVPYNQF 764
            |::..::|..:.     ||::......:.|:.....|..|.....|.:   :...:....|.:..
  Rat   644 LLDCGLRLKKVSFAERGAGRRRPGPSPDGLLEEGSPTMVEKGLEPGVFTLAEEDDEPEAPPSSPG 708

  Fly   765 TEDYNLL-----------------------------------------PAENNS----------- 777
            .|...:|                                         |.|.:|
  Rat   709 PEPQTVLLRRAGGEGRDQGSDGDRDPETGSGDAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESC 773

  Fly   778 ------LYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDI 836
                  .:.:|.||.||||::.|||.|||||.|.||:||:||:|.||.|:...|:||.|.|...|
  Rat   774 MKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESI 838

  Fly   837 GVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQVQPLL 901
            |.|..:|..:..:|:..:..:|             ...|                    |:|.|.
  Rat   839 GQWQKVMEAMGVLAIVVNCYLI-------------GQCG--------------------QLQRLF 870

  Fly   902 GGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVS 966
                                    |:..|       ...:..:|:.:::..:::.::..|:||:.
  Rat   871 ------------------------PWLSP-------EAAIVSVVVLEHLALLVKYLIHAAIPDIP 904

  Fly   967 GRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNETVIR------NRDEA 1025
            |.:.:.:.:..:..||....:|:|...:..|.:   :::.|.|.|||:.|...|      .|:||
  Rat   905 GWVAEEMAKLEYQRREAFKRHERQAQQRFQQQQ---RRRREEEERQRHAEQQARRERDTGGREEA 966

  Fly  1026  1025
              Rat   967  966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	44/221 (20%)
		Anoctamin	395..977	CDD:282414	164/814 (20%)
Ano8	XP_038950925.1	Anoctamin	237..913	CDD:398306	164/812 (20%)
		PRK12323	<961..>1139	CDD:237057	3/6 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920