Protein Alignment CG10353 and Ano2

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_705817.2
• Gene: Ano2 / 243634
• MGIID: 2387214
• Length: 1002
• Species: Mus musculus
• Alignment Length: 982
• Identity: 357/982 - (36%)
• Similarity: 510/982 - (51%)
• Gaps: 143/982 - (14%)

  Fly   127 GRNHLPTGIGVTGDGGQGGGDD------EVSRRLLRTSSNISNK--DKKLPITYSQWKSRTYRRF 183
            |..|....:.|.|....|..|:      :||||......::.|.  |...|.:.....||.:  |
Mouse    30 GPKHGQQYLKVPGHRAPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPPSSEARLSRMH--F 92

  Fly   184 DDGKRSVDFVLAY----------------------NGETQLEEH-------------------RR 207
            .|.:|.||:||||                      ||||..|.|                   |.
Mouse    93 HDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLDALEEERRE 157

  Fly   208 KCEIFEANLQREGLQLE---HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAES 269
            :.:.||.||...||:||   .:|.|...|::||||.:||.|.||.||||||.|.:
Mouse   158 QRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKM---------- 212

  Fly   270 AHEFKT------CFSRMCKSLFSSVQLNTALFPE----REPRIHLEFSRNYLELYD-TEHPNFLD 323
             :|.|.      .||.:.::|.|.:|...   ||    |...:...|||..:.||: .|...|.|
Mouse   213 -YEIKAGGSIAKKFSAILQTLSSPLQPRV---PEHSNNRMKNLSYPFSREKMYLYNIQEKDTFFD 273

  Fly   324 ASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLH---------DKDDRDRLLKE 379
            .:||..|::.||:|........|   :||..|:.:.:|..||.||         |.:||..|.:|
Mouse   274 NATRSRIVHEILKRTACSRANNT---MGINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQE 335

  Fly   380 WANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDI 444
            ||....:...||:|.|:.|||.|:.|||||||.||..|||.||.||:.||||..|...|..|:::
Mouse   336 WARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEM 400

  Fly   445 CD-DNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGL 508
            || .|...|||.||:|||||.|:..|.:::.::|.||..||.|:..||:||.::||.|||....|
Mouse   401 CDHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRL 465

  Fly   509 VHRWGLTGFTHH----VEHPRPQYLARI----------SRTKKLAGKAYEQDHTGKRTILDPDVP 559
            .:.|.|||....    .||.||:|..::          |..:||...:.|.|..      |.|..
Mouse   466 GYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDED------DEDKL 524

  Fly   560 FWSFKF---LPNFTSYSIMVLF-ICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPMTA 620
            .|..:|   |.||.|    :|| |.::...:.|:|:||:...|:.| |........:|.: ..||
Mouse   525 TWKDRFPGYLMNFAS----ILFMIALTFSIVFGVIVYRITTAAALS-LNKATRSNVRVTV-TATA 583

  Fly   621 GIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFV 685
            .||:|:||.:||.:|..:|..||..|..:|:..::|.|.:|.::.:|||.||.:||:||.||:||
Mouse   584 VIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFV 648

  Fly   686 GYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAV-NAIVEMLIPYLMRTFKELSYRHG 748
            |.|..|..|. |:|.|||.|||||||||:||.|||.|||.: |.|.|:.:|.|.:.|::|.....
Mouse   649 GRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETE 713

  Fly   749 WYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIE 813
            ..:|..|....| .|:..|::|.|  ...|..||:||::||||:|||..:|||||:.||||||||
Mouse   714 PGESDPDHSKRP-EQWDLDHSLEP--YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIE 775

  Fly   814 VRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMG-DP 877
            |||||.|.:..||||..:|.:|||:|..|::.:.:.:|..:|.:||.:::.||::||..|.. :.
Mouse   776 VRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNG 840

  Fly   878 ELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNE------TVCRYTEFRNSPEDPHPYKRPMIYWKI 936
            .|:.::|.||:.||     |..|..|:|..|.      ..||:.::|..|..|:||:....||.:
Mouse   841 TLHGFVNHTLSFFN-----VSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSV 900

  Fly   937 LTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELN 1001
            |:.||||::|:||::..|..::.|.:||:...:..:||:|..||.:..:: |:...:||..   .
Mouse   901 LSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLK-EEHEKVKLAD---E 961

  Fly  1002 GQQKSEG 1008
            ..|:|:|
Mouse   962 PTQRSQG 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	84/272 (31%)
		Anoctamin	395..976	CDD:461349	247/608 (41%)
Ano2	NP_705817.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..85		13/54 (24%)
		Anoct_dimer	91..348	CDD:465044	84/275 (31%)
		Anoctamin	351..940	CDD:461349	247/608 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..523		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	958..1002		4/14 (29%)
		DLG4 binding (PDZ)	1000..1002