Protein Alignment CG10353 and Ano5

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_006540885.4
• Gene: Ano5 / 233246
• MGIID: 3576659
• Length: 988
• Species: Mus musculus
• Alignment Length: 910
• Identity: 314/910 - (34%)
• Similarity: 486/910 - (53%)
• Gaps: 118/910 - (12%)

  Fly   156 RTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAY------NGETQLEEHRRKCEIFEA 214
            :.:|.:..:|.:.|...|: .|:....|.||.|.:||||:|      :||.:.|..|.    ||.
Mouse   123 KETSFLIPEDLQSPFQRSE-HSKDSVFFRDGIRQIDFVLSYVEDLKKDGELKAERRRE----FEQ 182

  Fly   215 NLQREGLQLE-----HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLK----PIPGQDQIFAESA 270
            ||::.||.||     :::..:.:|:|||||.|||..|||:|.||:|:|    |.|....:
Mouse   183 NLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLVTYAEVLGIKMPIKLSDIPRPKYPPL----- 242

  Fly   271 HEFKTCFSRMCKSLFSSVQLNTAL-FPEREPRIHLEFSRNYLELYDTE-HPNFLDASTRYSIINF 333
                       ..:..:|:|.::: :|..| ....:|||:..||:..| ...|..:|||..|:.:
Mouse   243 -----------SYMLGAVKLPSSVKYPTPE-YFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYY 295

  Fly   334 ILQRQRFVEG-EETADNLGIEKLVQDGVYTCAYTLHD-----------KDDRDRLLKEWANISKW 386
            ||.|..|  | ||....:|||:|:....|..||.|||           .::|..|.|.||..|.:
Mouse   296 ILSRCPF--GVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYF 358

  Fly   387 KNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICD-DNG- 449
            ...||...|::|||.|:.:||.:||:||:||:..::.|:.||:||.::..::..|.:||| |.|
Mouse   359 YKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMENNRTSTEICDPDIGG 423

  Fly   450 -TIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWG 513
             .||||.||..|||||||.||..|||::|.||..||.||..|.||..::|||||:..|.|.:.|.
Mouse   424 QMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFWKQRQARLEYEWD 488

  Fly   514 LTGFTHHVE--HPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPF-----WSFKFLPNFTS 571
            |..|....:  ..||::.| :.:.||:.....|         ::|.:|.     |      .|.|
Mouse   489 LVDFEEEQQQLQLRPEFEA-MCKHKKMNPVTKE---------MEPHMPLCHRIPW------YFVS 537

  Fly   572 YSIMVLFICISVIAIAGIIIYRMAQRA-------SHSILGSENSMTFKVMILPMTAGIIDLIVIS 629
            .:.:...:.:.:.::..|:|||::..|       |.:.|.|..|.....:...::...::.|||.
Mouse   538 GTTVTFGMALLLSSMVSILIYRLSVFATFASFMESEATLQSVKSFFTPQLATALSGSCLNCIVIL 602

  Fly   630 LLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRV 694
            :|:..|..::..:|..|..||..||:.|||:|.::|||||||||.||:||.||||||||..|..:
Mouse   603 ILNFFYEKISAWITKMEIPRTHQEYESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYM 667

  Fly   695 LG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRL 758
            .. :|.|||.|.|||:||..||.|||.|||....|.|...|.:...::....|     :|.::.
Mouse   668 FNIWRSEECGPAGCLIELTTQLTIIMIGKQIFGNIHEAFQPLIFNWWRRRRAR-----THSEKL- 726

  Fly   759 VPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLR 823
              |:::.:|::|....:..|:.||||.|:||||.|||..:||||||.||:||::.:|:||.|:..
Mouse   727 --YSRWEQDHDLQVYGHRGLFYEYLETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTT 789

  Fly   824 FLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIV--YAASMGDPE-LNNYLNF 885
            ..||||..:|..||||..|:..:..::||::|.|::|::::||::|  ||.|....| |:.|:|.
Mouse   790 QYRRPVAAKAHSIGVWQDILFGMAIVSVATNAFIVSFTSDIIPRLVYFYAYSTNSTEPLSGYVNN 854

  Fly   886 TLAVFNTKDFQVQPLLGGSQHVNETV---------CRYTEFRNSPEDPHPYKRPMIYWKILTGRL 941
            :|:||...||.           |.||         |||.::|..|:....|...|.:|.:|..::
Mouse   855 SLSVFLIADFP-----------NHTVPMEKKDFVTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKM 908

  Fly   942 AFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKS 1006
            .||::.::::.:.:.:|.|.:|||...::::||||..:..:.|.::|.....:.:..|.....|:
Mouse   909 TFIIVMEHVVFLFKFLLAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKN 973

  Fly  1007  1006
            Mouse   974  973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	79/237 (33%)
		Anoctamin	395..976	CDD:461349	223/610 (37%)
Ano5	XP_006540885.4	Anoct_dimer	148..363	CDD:465044	78/237 (33%)
		Anoctamin	367..943	CDD:461349	223/610 (37%)