DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and Ano3

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001121575.1	Gene:	Ano3 / 228432	MGIID:	3613666	Length:	981	Species:	Mus musculus

Alignment Length:	1062	Identity:	347/1062 - (32%)
Similarity:	526/1062 - (49%)	Gaps:	174/1062 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ESEMDERESLYFDTISLAESEAAAAAAAHRKSISQSRNTIYH---------SAVDLAGDEGGGGS 69
            :||:....||.....||   ...|.:.||.||:|||.:....         |...|:.|:
Mouse    21 KSEITTEASLKPSRRSL---PCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADK----- 77

  Fly    70 GGGRLRLGGGAAAEHAALAWQPGYRQSTALEHLNGGGGGGGDHTDAAIAAQMIALQNGRNHLPTG 134
                        .||..   ....|:.:.|:           .:.|.::...:||...:::|
Mouse    78 ------------PEHVT---SEESRKDSTLK-----------CSFADLSDFCLALGKDKDYL--- 113

  Fly   135 IGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTY-----RRFDDGKRSVDFVL 194
                 |..:....|.  .|||   ::...|||....|.......:|     ..|.|||:.:|::|
Mouse   114 -----DESEHANYDR--SRLL---NDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYIL 168

  Fly   195 AYNGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIKVPL 256
            .|. :|.::..:|  ..||.||:.|||.||....   ..:.|||||.|.:.|.:|||.|.|:||.
Mouse   169 VYR-KTNIQYDKR--NTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPF 230

  Fly   257 KPIPGQDQIFAESAHEFKTCFSRMCKSLFSS-VQLNTALFPERE-----------PRIHLEFSRN 309
            :..........:|....:..|.|:.|.:..: :.|:.:.|||.|           .|||.....|
Mouse   231 RKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINN 295

  Fly   310 YLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD----- 369
                .||    |...:||..|:..:|:|.::..|   ...:||.||:.:|.|..|:..|:
Mouse   296 ----KDT----FFSNATRSRIVYHMLERTKYENG---ISKVGIRKLITNGSYIAAFPPHEGAYKS 349

  Fly   370 ---------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGV 425
                     :::|..|.:.||....|...||||.|:.|||.|:.|||||||:||.||||.:|.|:
Mouse   350 SLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGL 414

  Fly   426 LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSM 490
            ..|.||.:|.|...:|::||......|||.||::|...|||::|..:|..||.||..||.||..|
Mouse   415 CVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFM 479

  Fly   491 AIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILD 555
            ||||.|:||||||..:.|.:.|.|..:....|..|||:.|:..|.:.:      ...|||.   :
Mouse   480 AIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVI------NPITGKP---E 535

  Fly   556 PDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPM-- 618
            |..|. |.|......|.|.:...|.:.:.|:..:::||        ::..|...:||...:..
Mouse   536 PHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYR--------LVVMEQFASFKWNFVKQHW 591

  Fly   619 ---TAG---IIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYI 677
               |:|   .|:.|:|.||::.|..:|..|||.||.||::|::.|..:|.::|||||..||:|||
Mouse   592 QFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYI 656

  Fly   678 AFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFK 741
            ||..|:|||:|.|||::. .:|.|||:|.|||::||:|:.:||..||..|..:|:..|.:
Mouse   657 AFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLI----- 716

  Fly   742 ELSYRHGWYKSHQDQR-----LVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPL 801
                 ..|:..|:.:|     .:|  |:..|:||.|...:.|..||||||:||||.|:|..||||
Mouse   717 -----QNWWSRHKIKRGIQDASIP--QWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPL 774

  Fly   802 APLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIP 866
            |||||||||:||:||||.|.:...|||:..||.|||:|..|:..:..:||.::|.:||.:::.||
Mouse   775 APLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIP 839

  Fly   867 KIVYAASMG---------DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPE 922
            :.||....|         :..|..|:|.:|:.|:..:..    :|.|.:     |||.::|..|.
Mouse   840 RFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELG----MGKSGY-----CRYRDYRGPPW 895

  Fly   923 DPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEY 987
            ...||:..:.||.||..|||||:::::::..::..:.:.:||:...|.:||:||.:|::|.:.|.
Mouse   896 SSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEA 960

  Fly   988 EKQHAMKLVQTELNGQQKSEGE 1009
            |.:|        |..|::..|:
Mouse   961 ELEH--------LQQQRRKSGQ 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	68/237 (29%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	232/604 (38%)
Ano3	NP_001121575.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..87		5/39 (13%)
		Anoct_dimer	157..381	CDD:292796	68/237 (29%)
		Anoctamin	384..950	CDD:282414	232/604 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850