Protein Alignment CG10353 and Ano3

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001121575.1
• Gene: Ano3 / 228432
• MGIID: 3613666
• Length: 981
• Species: Mus musculus
• Alignment Length: 1062
• Identity: 347/1062 - (32%)
• Similarity: 526/1062 - (49%)
• Gaps: 174/1062 - (16%)

  Fly    14 ESEMDERESLYFDTISLAESEAAAAAAAHRKSISQSRNTIYH---------SAVDLAGDEGGGGS 69
            :||:....||.....||   ...|.:.||.||:|||.:....         |...|:.|:
Mouse    21 KSEITTEASLKPSRRSL---PCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADK----- 77

  Fly    70 GGGRLRLGGGAAAEHAALAWQPGYRQSTALEHLNGGGGGGGDHTDAAIAAQMIALQNGRNHLPTG 134
                        .||..   ....|:.:.|:           .:.|.::...:||...:::|
Mouse    78 ------------PEHVT---SEESRKDSTLK-----------CSFADLSDFCLALGKDKDYL--- 113

  Fly   135 IGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTY-----RRFDDGKRSVDFVL 194
                 |..:....|.  .|||   ::...|||....|.......:|     ..|.|||:.:|::|
Mouse   114 -----DESEHANYDR--SRLL---NDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYIL 168

  Fly   195 AYNGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIKVPL 256
            .|. :|.::..:|  ..||.||:.|||.||....   ..:.|||||.|.:.|.:|||.|.|:||.
Mouse   169 VYR-KTNIQYDKR--NTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPF 230

  Fly   257 KPIPGQDQIFAESAHEFKTCFSRMCKSLFSS-VQLNTALFPERE-----------PRIHLEFSRN 309
            :..........:|....:..|.|:.|.:..: :.|:.:.|||.|           .|||.....|
Mouse   231 RKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINN 295

  Fly   310 YLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD----- 369
                .||    |...:||..|:..:|:|.::..|   ...:||.||:.:|.|..|:..|:
Mouse   296 ----KDT----FFSNATRSRIVYHMLERTKYENG---ISKVGIRKLITNGSYIAAFPPHEGAYKS 349

  Fly   370 ---------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGV 425
                     :::|..|.:.||....|...||||.|:.|||.|:.|||||||:||.||||.:|.|:
Mouse   350 SLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGL 414

  Fly   426 LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSM 490
            ..|.||.:|.|...:|::||......|||.||::|...|||::|..:|..||.||..||.||..|
Mouse   415 CVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFM 479

  Fly   491 AIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILD 555
            ||||.|:||||||..:.|.:.|.|..:....|..|||:.|:..|.:.:      ...|||.   :
Mouse   480 AIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVI------NPITGKP---E 535

  Fly   556 PDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPM-- 618
            |..|. |.|......|.|.:...|.:.:.|:..:::||        ::..|...:||...:..
Mouse   536 PHQPS-SDKVTRLLVSVSGIFFMISLVITAVFAVVVYR--------LVVMEQFASFKWNFVKQHW 591

  Fly   619 ---TAG---IIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYI 677
               |:|   .|:.|:|.||::.|..:|..|||.||.||::|::.|..:|.::|||||..||:|||
Mouse   592 QFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYI 656

  Fly   678 AFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFK 741
            ||..|:|||:|.|||::. .:|.|||:|.|||::||:|:.:||..||..|..:|:..|.:
Mouse   657 AFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLI----- 716

  Fly   742 ELSYRHGWYKSHQDQR-----LVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPL 801
                 ..|:..|:.:|     .:|  |:..|:||.|...:.|..||||||:||||.|:|..||||
Mouse   717 -----QNWWSRHKIKRGIQDASIP--QWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPL 774

  Fly   802 APLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIP 866
            |||||||||:||:||||.|.:...|||:..||.|||:|..|:..:..:||.::|.:||.:::.||
Mouse   775 APLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIP 839

  Fly   867 KIVYAASMG---------DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPE 922
            :.||....|         :..|..|:|.:|:.|:..:..    :|.|.:     |||.::|..|.
Mouse   840 RFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELG----MGKSGY-----CRYRDYRGPPW 895

  Fly   923 DPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEY 987
            ...||:..:.||.||..|||||:::::::..::..:.:.:||:...|.:||:||.:|::|.:.|.
Mouse   896 SSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEA 960

  Fly   988 EKQHAMKLVQTELNGQQKSEGE 1009
            |.:|        |..|::..|:
Mouse   961 ELEH--------LQQQRRKSGQ 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	68/237 (29%)
		Anoctamin	395..976	CDD:461349	231/603 (38%)
Ano3	NP_001121575.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..87		5/39 (13%)
		Anoct_dimer	157..381	CDD:465044	68/237 (29%)
		Anoctamin	384..949	CDD:461349	231/603 (38%)