DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ANO6

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001191732.1	Gene:	ANO6 / 196527	HGNCID:	25240	Length:	931	Species:	Homo sapiens

Alignment Length:	900	Identity:	336/900 - (37%)
Similarity:	507/900 - (56%)	Gaps:	118/900 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAYNGETQL--------EEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKI 236
            |:||:|.:||||.|..|::.        |:.|||.:.:|:||...|||||..:.   .::.|:|:
Human    83 FNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKV 147

  Fly   237 HAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPERE-- 299
            |||.|||..||||:.||:||||   .|.....||......|:::. |:..|:     :.||:|
Human   148 HAPWEVLCTYAEIMHIKLPLKP---NDLKNRSSAFGTLNWFTKVL-SVDESI-----IKPEQEFF 203

  Fly   300 --PRIHLEFSRNYL-ELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNL---GIEKLVQD 358
              |     |.:|.: :.|..:...|.:.:||..|:.|||.|.::    :..:|:   ||.:||..
Human   204 TAP-----FEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY----QVINNVSKFGINRLVNS 259

  Fly   359 GVYTCAYTLHD------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLG 411
            |:|..|:.|||            .::|..|.:|||:.......||||.|:.|:|.|:.:||||||
Human   260 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLG 324

  Fly   412 FYTQMLIPISVFGVLCFLYGFITWNSDPISRDIC--DDNG-TIMCPQCDRSCDYWRLNETCTSSK 473
            :|||||:..:|.||.|||||::..::...|:::|  |..| .||||||||.|.:|:||.||.|||
Human   325 YYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSK 389

  Fly   474 FNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKL 538
            ...:.|:..|:|||..|.:|..::||||||..|.|.:.|. |......|..||:|.||.  |..:
Human   390 KLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWD-TVELQQEEQARPEYEARC--THVV 451

  Fly   539 AGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA-IAGIIIYRM------AQ 596
            ..:..:::..         :||.::......|..:..|.|..:.:|| :.|||:||:      :.
Human   452 INEITQEEER---------IPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSA 507

  Fly   597 RASHSILGSENSMTFKVMILP-----MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDE 656
            :...:|.|::....:   :.|     :||.||..|:|.:|:.:|..:|:.:||:|..||||:|:.
Human   508 KLPKNINGTDPIQKY---LTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 569

  Fly   657 SLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMA 720
            |||:|.::|||||||||.|||||.||||||||......|| :|.|||:|||||:||..||.|||.
Human   570 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMG 634

  Fly   721 GKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEM 785
            ||...|.|.|:|:|::|.....      :::....:::.|  ::.:||:|.|.....|:.|||||
Human   635 GKAIWNNIQEVLLPWIMNLIGR------FHRVSGSEKITP--RWEQDYHLQPMGKLGLFYEYLEM 691

  Fly   786 VVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIA 850
            ::||||:|||..:|||||||||:||::|:|:||.|:....||.|..:|:|||.|..||..:..:|
Human   692 IIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 756

  Fly   851 VASSAMIIAFSTNLIPKIVYAASMGDP--------ELNNYLNFTLAVFNTKDFQVQPL------L 901
            |.::||||||::::||::||..|...|        .:..|:|.||::|...||:.:..      |
Human   757 VVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDL 821

  Fly   902 GGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVS 966
            |     |.|.|||.:||..|..|..||..:.||.::..:||||::.:::|..::..:.:|:||||
Human   822 G-----NHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVS 881

  Fly   967 GRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNETVIRN 1021
            .|...:|:||.:|.::           .|.:..|....|:.|.:.:|..|.|..|
Human   882 KRTKSKIQREKYLTQK-----------LLHENHLKDMTKNMGVIAERMIEAVDNN 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	78/239 (33%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	245/611 (40%)
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:292796	78/239 (33%)
ANO6	NP_001191732.1	Anoctamin	308..892	CDD:282414	245/611 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780