DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and anoh-1

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001255190.1	Gene:	anoh-1 / 176739	WormBaseID:	WBGene00010138	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	921	Identity:	223/921 - (24%)
Similarity:	385/921 - (41%)	Gaps:	219/921 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 SVDFVLAYNGETQLEEHRRKCEIFEANLQREGLQLEHNKVQRVHFIKIHAPAEVLYRYAEILKIK 253
            |:||||.:|......:.:.: |.||..:|:|||.:.|.:..:.||..|..|...|.|.||:.::.
Worm    36 SIDFVLVHNAAESRSKGKYR-EFFEKAVQKEGLIIRHQQSGQTHFTLISTPFHRLTREAEMSQMC 99

  Fly   254 VPLKPI---PG-------QDQIFA--ESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEF 306
            .|||..   ||       ..|||.  ::.......|.|...|||.:.....:.|...:
Worm   100 FPLKDCQVKPGLPSCCIPLSQIFVTDDTVRFINAPFQRKHGSLFLNYHDEKSFFTSSQ------- 157

  Fly   307 SRNYLELYDTEHPNFLDASTRYSIINFI-----LQRQRFVEGEE----------TAD----NLGI 352
             |.||               .|.|:..|     |:.:|..|.::          |:|    ..|:
Worm   158 -RGYL---------------TYQILTKIDISKDLKGERLGESQDEPTDPSTSSITSDEQLRRKGL 206

  Fly   353 EKLVQDGVYTCAYTLH---------------------------DKDDRDRLLKEWANISKWKNLQ 390
            ..|:...||..|:.||                           :.|.|..|...|   .:|...|
Worm   207 SWLLMSDVYEEAFVLHAPSKEEPYFKAMQNGSVKAYNEFISEIELDPRRSLSLNW---ERWYKFQ 268

  Fly   391 PLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFI-TWNSDPISRDIC------DDN 448
            ||::|:||||.::|.||||.|.:..:|.|..:||::.|:|||| :.:|.|:..:.|      ...
Worm   269 PLNKIRDYFGEQIAYYFAWQGTFLTLLWPAVIFGLVVFIYGFIDSISSAPLDWNHCKVVNFIGQT 333

  Fly   449 GTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWG 513
            ..:.|...:....::.:......|.|    |..|...||..|:||..|:::.|||.::.|.::|.
Worm   334 ENVACGMRNGVTLFFSMVTQWFMSSF----DTKMNAFFAVFMSIWGSVFVQIWKRNNSVLSYQWN 394

  Fly   514 LTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPN--FTSYSIMV 576
            ...| |.:|..||::  |.|:.|       |...||:...:.|.:..: .|.|.:  |.|:|::|
Worm   395 SDDF-HAIEPDRPEF--RGSKVK-------EDPITGEDIWISPALARY-IKMLASFVFVSFSMLV 448

  Fly   577 LFICISVIAIAGI-IIYRMAQRASHSILGSENSMTF----KVMILPMTAGIIDLIVISLLDMVYS 636
            :.|.:.::.:..| ::|...         .....||    ....||   .|::.:....|..:||
Worm   449 VVISLMLVTLLKIWMVYNFQ---------CTKEYTFHCWLSAAFLP---SILNTLSAMGLGAIYS 501

  Fly   637 NLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQE- 700
            ||..:|.::|..||::|::.||.:|.:.||.||.|:||||:||::.:..|  .:.|.:.|...|
Worm   502 NLVSRLNSWENHRTESEHNNSLIVKIFAFQMVNTYTSLFYVAFIRPESHG--LQPNGLFGLGTEF 564

  Fly   701 --ECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQ 763
              .|....|...|.:||:.....|.......::::||.::.|     |...|.|..:.|:    :
Worm   565 KDTCLDDTCSSLLALQLLTHTLIKPFPKFFKDVVLPYFVKLF-----RLRMYTSRTEARV----E 620

  Fly   764 FTED--YNLL------PAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIK 820
            ..:|  .|:|      |:..:.:..|..|.::.||...:|:..|||||||||:...:::|:||.:
Worm   621 IEDDDQANVLVREWLKPSAGDFVLWEMNEKIILFGTTMMFASLFPLAPLLALIIGFVDMRIDAHR 685

  Fly   821 MLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNF 885
            ::.|.|:|:.:....||:|..|:|.:...||.::|.|:||
Worm   686 LIWFNRKPIPIITNGIGIWLPILTFLQYCAVFTNAFIVAF------------------------- 725

  Fly   886 TLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNI 950
                  |..|....|..|:         |...:|                    ||..::::||:
Worm   726 ------TSGFCSTFLADGA---------YCTVQN--------------------RLIIVIVFQNL 755

  Fly   951 ITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIE----------YEKQHAMKLVQTELNGQQK 1005
            :..|:.:|...:|.:...:...::::.::: .||:|          .::....||.....|.:..
Worm   756 VFGLKYLLSSVIPSIPASIKLALRKKRYVV-AHIVEKGDVPHRTRIKKRTRIAKLAWIASNQKMI 819

  Fly  1006 SEGELRQRNNE 1016
            .....::::|:
Worm   820 KSNRKKEKSNK 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	60/260 (23%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	154/606 (25%)
anoh-1	NP_001255190.1	Anoct_dimer	36..270	CDD:292796	60/260 (23%)
anoh-1	NP_001255190.1	Anoctamin	273..782	CDD:282414	154/606 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I1994
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28924
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm14612
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.910