Protein Alignment CG10353 and anoh-1

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001255190.1
• Gene: anoh-1 / 176739
• WormBaseID: WBGene00010138
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 921
• Identity: 223/921 - (24%)
• Similarity: 385/921 - (41%)
• Gaps: 219/921 - (23%)

  Fly   189 SVDFVLAYNGETQLEEHRRKCEIFEANLQREGLQLEHNKVQRVHFIKIHAPAEVLYRYAEILKIK 253
            |:||||.:|......:.:.: |.||..:|:|||.:.|.:..:.||..|..|...|.|.||:.::.
 Worm    36 SIDFVLVHNAAESRSKGKYR-EFFEKAVQKEGLIIRHQQSGQTHFTLISTPFHRLTREAEMSQMC 99

  Fly   254 VPLKPI---PG-------QDQIFA--ESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEF 306
            .|||..   ||       ..|||.  ::.......|.|...|||.:.....:.|...:
 Worm   100 FPLKDCQVKPGLPSCCIPLSQIFVTDDTVRFINAPFQRKHGSLFLNYHDEKSFFTSSQ------- 157

  Fly   307 SRNYLELYDTEHPNFLDASTRYSIINFI-----LQRQRFVEGEE----------TAD----NLGI 352
             |.||               .|.|:..|     |:.:|..|.::          |:|    ..|:
 Worm   158 -RGYL---------------TYQILTKIDISKDLKGERLGESQDEPTDPSTSSITSDEQLRRKGL 206

  Fly   353 EKLVQDGVYTCAYTLH---------------------------DKDDRDRLLKEWANISKWKNLQ 390
            ..|:...||..|:.||                           :.|.|..|...|   .:|...|
 Worm   207 SWLLMSDVYEEAFVLHAPSKEEPYFKAMQNGSVKAYNEFISEIELDPRRSLSLNW---ERWYKFQ 268

  Fly   391 PLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFI-TWNSDPISRDIC------DDN 448
            ||::|:||||.::|.||||.|.:..:|.|..:||::.|:|||| :.:|.|:..:.|      ...
 Worm   269 PLNKIRDYFGEQIAYYFAWQGTFLTLLWPAVIFGLVVFIYGFIDSISSAPLDWNHCKVVNFIGQT 333

  Fly   449 GTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWG 513
            ..:.|...:....::.:......|.|    |..|...||..|:||..|:::.|||.::.|.::|.
 Worm   334 ENVACGMRNGVTLFFSMVTQWFMSSF----DTKMNAFFAVFMSIWGSVFVQIWKRNNSVLSYQWN 394

  Fly   514 LTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPN--FTSYSIMV 576
            ...| |.:|..||::  |.|:.|       |...||:...:.|.:..: .|.|.:  |.|:|::|
 Worm   395 SDDF-HAIEPDRPEF--RGSKVK-------EDPITGEDIWISPALARY-IKMLASFVFVSFSMLV 448

  Fly   577 LFICISVIAIAGI-IIYRMAQRASHSILGSENSMTF----KVMILPMTAGIIDLIVISLLDMVYS 636
            :.|.:.::.:..| ::|...         .....||    ....||   .|::.:....|..:||
 Worm   449 VVISLMLVTLLKIWMVYNFQ---------CTKEYTFHCWLSAAFLP---SILNTLSAMGLGAIYS 501

  Fly   637 NLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQE- 700
            ||..:|.::|..||::|::.||.:|.:.||.||.|:||||:||::.:..|  .:.|.:.|...|
 Worm   502 NLVSRLNSWENHRTESEHNNSLIVKIFAFQMVNTYTSLFYVAFIRPESHG--LQPNGLFGLGTEF 564

  Fly   701 --ECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQ 763
              .|....|...|.:||:.....|.......::::||.::.|     |...|.|..:.|:    :
 Worm   565 KDTCLDDTCSSLLALQLLTHTLIKPFPKFFKDVVLPYFVKLF-----RLRMYTSRTEARV----E 620

  Fly   764 FTED--YNLL------PAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIK 820
            ..:|  .|:|      |:..:.:..|..|.::.||...:|:..|||||||||:...:::|:||.:
 Worm   621 IEDDDQANVLVREWLKPSAGDFVLWEMNEKIILFGTTMMFASLFPLAPLLALIIGFVDMRIDAHR 685

  Fly   821 MLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNF 885
            ::.|.|:|:.:....||:|..|:|.:...||.::|.|:||
 Worm   686 LIWFNRKPIPIITNGIGIWLPILTFLQYCAVFTNAFIVAF------------------------- 725

  Fly   886 TLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNI 950
                  |..|....|..|:         |...:|                    ||..::::||:
 Worm   726 ------TSGFCSTFLADGA---------YCTVQN--------------------RLIIVIVFQNL 755

  Fly   951 ITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIE----------YEKQHAMKLVQTELNGQQK 1005
            :..|:.:|...:|.:...:...::::.::: .||:|          .::....||.....|.:..
 Worm   756 VFGLKYLLSSVIPSIPASIKLALRKKRYVV-AHIVEKGDVPHRTRIKKRTRIAKLAWIASNQKMI 819

  Fly  1006 SEGELRQRNNE 1016
            .....::::|:
 Worm   820 KSNRKKEKSNK 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	60/260 (23%)
		Anoctamin	395..976	CDD:461349	154/605 (25%)
anoh-1	NP_001255190.1	Anoct_dimer	36..270	CDD:465044	60/260 (23%)
		Anoctamin	273..781	CDD:461349	154/605 (25%)