DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ANO4

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_011536213.1	Gene:	ANO4 / 121601	HGNCID:	23837	Length:	1121	Species:	Homo sapiens

Alignment Length:	1116	Identity:	350/1116 - (31%)
Similarity:	549/1116 - (49%)	Gaps:	217/1116 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PESEMDERESLYFDTISLAESEAAAAAAAHRKSISQSRNTIYHSAVDLAGDEGGGGSGGGRLRLG 77
            |......:|:|..||..|:.|   ...|..|..|.|.|:.....|              .|.||
Human   104 PSYSSSSQETLSQDTTGLSLS---IHGAEKRLQIHQRRSVASRPA--------------SRRRL- 150

  Fly    78 GGAAAEHAALAWQPGYRQSTALEHLNGGGGGGGDHTDAAIAAQMIALQNGRN---HLPTGIGVTG 139
              ....|::|  .|| |:|..:|..:.|                  :.||:.   |...|:.:.|
Human   151 --PVVRHSSL--PPG-RRSIKMEASSSG------------------ITNGKTKVFHPEGGVDLQG 192

  Fly   140 ---------DGGQGGGD-------------------DEVSR---------------RLLRTSSNI 161
                     ||.:...|                   ||:..               .|..||.:.
Human   193 YQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDA 257

  Fly   162 S------------NKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYNGETQLEEHRRKCEIFEA 214
            |            ||...|             .|.|||..:|::|.|.......|.|   |:||.
Human   258 SRLEAGGETVPERNKSNGL-------------YFRDGKCRIDYILVYRKSNPQTEKR---EVFER 306

  Fly   215 NLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIKVPLKP----IPGQDQIFA---ES 269
            |::.||||:|....   ..:.|:|:|||.|||.||||.:.:::|.:.    :|.:.:..:   :.
Human   307 NIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQ 371

  Fly   270 AHEFKTCF----SRMCKSLFSSVQLN---TALFPEREPRIHLEFSRNYLELYDTEHPNFLDASTR 327
            ...|:...    .|:.|.....::.|   ||.|.::  |||      :..:::.|  .|.:.:||
Human   372 ISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQ--RIH------HFIIHNKE--TFFNNATR 426

  Fly   328 YSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHDKDDRDR-------------LLKE 379
            ..|::.||||.::.||:   :.:|:.:|:.:|.|..|:.||:...|.:             ||.|
Human   427 SRIVHHILQRIKYEEGK---NKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYE 488

  Fly   380 -WANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRD 443
             ||:...|...||||.::.|||.|:.|||||||:||.||.|.:..|:..||||..|.:...:|::
Human   489 CWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKE 553

  Fly   444 ICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGL 508
            :|.....||||.||:.|.:.||:::|..:|..:|.||..||.||..||:||.|:||||||..|.:
Human   554 VCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVI 618

  Fly   509 VHRWGLTGFTHHVEHPRPQYLARISRTKK---LAGKAYEQDHTGKRTILDPDVPFWSF--KFLPN 568
            .:.|.|..:....|..|||:.|:.|:.::   ::||              |: |:.:|  |....
Human   619 AYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGK--------------PE-PYQAFTDKCSRL 668

  Fly   569 FTSYSIMVLFICISVIAIAGIIIYRMAQRASHS----ILGSENSMTFKVMILPMTAGIIDLIVIS 629
            ..|.|.:...||:.:.|:.||:|||:...::.:    .|...||.    :....||..|:..:|.
Human   669 IVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQ----VATTGTAVCINFCIIM 729

  Fly   630 LLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRV 694
            ||:::|..:|:.|||.|..||::|::.|.|:|.::|||||..||.|||||..|:|.|:|..|.|:
Human   730 LLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRL 794

  Fly   695 LG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRL 758
            :. :|.|||:|.|||::||||:.|||..||..|..:|:..|.:...:.....|    :.|..:|.
Human   795 INRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVR----QEHGPERK 855

  Fly   759 VPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLR 823
            :.:.|:.:||||.|.....|:.|||||::||||.|:|..|||||||||||||:||:||||.|.:.
Human   856 ISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVT 920

  Fly   824 FLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYA---------ASMGDPEL 879
            ..|||:..||:|||:|:.|:..:..::|.::|.:||.:::.||::|||         ...|...:
Human   921 QWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCM 985

  Fly   880 NNYLNFTLAVFNTKDFQ--VQPLLGGSQHVNETV--CRYTEFRNSPEDPHPYKRPMIYWKILTGR 940
            ..|:|.:|:||...||:  .:|...||:.....:  |||.::|:.|....||...:.:|.:|..|
Human   986 VGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAAR 1050

  Fly   941 LAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQK 1005
            ||||:::::::..::.::.:.:||:...|..|::||.:|::|.:.|           .||...||
Human  1051 LAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYE-----------AELERLQK 1104

  Fly  1006 SEGELRQRNNE 1016
            ...| |::|.:
Human  1105 ERKE-RKKNGK 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	68/239 (28%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	227/604 (38%)
ANO4	XP_011536213.1	Anoct_dimer	277..502	CDD:292796	68/240 (28%)
ANO4	XP_011536213.1	Anoctamin	505..1087	CDD:282414	227/604 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm8665
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850