Protein Alignment CG10353 and Ano6

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001240742.1
• Gene: Ano6 / 105722
• MGIID: 2145890
• Length: 932
• Species: Mus musculus
• Alignment Length: 893
• Identity: 334/893 - (37%)
• Similarity: 502/893 - (56%)
• Gaps: 111/893 - (12%)

  Fly   183 FDDGKRSVDFVLAYNGETQL--------EEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKI 236
            |.||:|.:||:|.|..|::.        |:.:||.:.:|:||...|||||..:.   .::.|:|:
Mouse    85 FTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSDDKLVFVKV 149

  Fly   237 HAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPR 301
            |||.|||..||||:.||:||||            ::.||      :|.|.::...|.:....|..
Mouse   150 HAPWEVLCTYAEIMHIKLPLKP------------NDLKT------RSPFGNLNWFTKVLRVNESV 196

  Fly   302 IHLE-------FSRNYL-ELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQD 358
            |..|       |.::.: :.|..:..:|.:.:||..|:.|||.|.:: :.....:..||.:||..
Mouse   197 IKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKY-QVMNNVNKFGINRLVSS 260

  Fly   359 GVYTCAYTLHD------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLG 411
            |:|..|:.|||            ..:|..|.:|||:.......||||.|:.|:|.|:.:||||||
Mouse   261 GIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLG 325

  Fly   412 FYTQMLIPISVFGVLCFLYGFITWNSDPISRDICD-DNG--TIMCPQCDRSCDYWRLNETCTSSK 473
            :|||||:..:|.||.|||||::..::...|:::|| |.|  .:|||||||.|.:||||.||.|||
Mouse   326 YYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSK 390

  Fly   474 FNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKL 538
            ...:.|:..|::||..|.:|..::||||||..|.|.:.|. |......|..||:|.|:.:..  :
Mouse   391 KLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWD-TVELQQEEQARPEYEAQCNHV--V 452

  Fly   539 AGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA-IAGIIIYRMAQRASHSI 602
            ..:..:::..         :||.:.......|..:..|.|..:.:|| :.|||:||::.....|.
Mouse   453 INEITQEEER---------IPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVFST 508

  Fly   603 L------GSENSMTFKV--MILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLT 659
            .      |::....:..  |...:||.||..|:|.:|:.:|..:|:.:||:|..||||:|:.|||
Mouse   509 TLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLT 573

  Fly   660 IKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAGKQ 723
            :|.::|||||||||.|||||.||||||||.....:|| :|.|||:|||||:||..||.|||.||.
Mouse   574 MKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKA 638

  Fly   724 AVNAIVEMLIPYLMRTFKELSYRHGWYKS-HQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVV 787
            ..|.|.|:|:|::|...       |.||. ...:::.|  ::.:||:|.|.....|:.|||||::
Mouse   639 IWNNIQEVLLPWVMNLI-------GRYKRVSGSEKITP--RWEQDYHLQPMGKLGLFYEYLEMII 694

  Fly   788 QFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVA 852
            ||||:|||..:|||||||||:||::|:|:||.|:....||.|..:|:|||.|..||..:..:||.
Mouse   695 QFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVV 759

  Fly   853 SSAMIIAFSTNLIPKIVYAASMGDP--------ELNNYLNFTLAVFNTKDF----QVQPLLGGSQ 905
            ::||||||::::||::||..|...|        .::.|:|.||:|||..||    :..|.:|..
Mouse   760 TNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLG- 823

  Fly   906 HVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLL 970
              |.|:|||.:|||.|..|..||..:.||.::..:||||::.::||..::..:.:|:||||....
Mouse   824 --NYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFISYAIPDVSKITK 886

  Fly   971 KRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNETV 1018
            .:||||.:|.::           .|.::.|....|:.|.:.:|...||
Mouse   887 SKIKREKYLTQK-----------LLHESHLKDLTKNMGIIAERIGGTV 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	72/239 (30%)
		Anoctamin	395..976	CDD:461349	249/606 (41%)
Ano6	NP_001240742.1	Anoct_dimer	84..306	CDD:465044	72/239 (30%)
		Anoctamin	309..892	CDD:461349	249/606 (41%)