Protein Alignment CG10353 and Ano10

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001408476.1
• Gene: Ano10 / 102566
• MGIID: 2143103
• Length: 670
• Species: Mus musculus
• Alignment Length: 654
• Identity: 162/654 - (24%)
• Similarity: 266/654 - (40%)
• Gaps: 186/654 - (28%)

  Fly   352 IEKLVQDGVYTCAYTLHDKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQM 416
            :.:|:..|:.|..:.|||.:...:|...|......| .||:|.|:.|||..:||||.:|.::|..
Mouse   158 MRRLLTSGIVTQVFPLHDTEALKKLEDTWYTRFALK-YQPIDSIRSYFGETIALYFGFLEYFTFA 221

  Fly   417 LIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNN 481
            |||:::.|:..:|:   .|.                                          |.:
Mouse   222 LIPMAIIGLPYYLF---VWE------------------------------------------DYD 241

  Fly   482 MTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQD 546
            ..|:||....||:.|.||.|||..|.:.:|||........|.|||.:...:
Mouse   242 KYVIFASFNLIWSTVILEVWKRGCANMTYRWGTLVMKRQFEEPRPGFHGVL-------------- 292

  Fly   547 HTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISV-IAIAGIIIYRMAQ---RASHSILGSEN 607
              |..::...:.|.:| .:......|.:.:.|:|:.: .::..::||...:   .:.|...|||
Mouse   293 --GINSVTGREEPLYS-SYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEDWALSLHEDSGSE- 353

  Fly   608 SMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYS 672
             .|..::.:|   .|:..:||.:::.:|...|..||::|..|.::.|...|.:|..||.|:|.::
Mouse   354 -WTSLLLYVP---SIVYAVVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLVLKVLVFNFLNCFA 414

  Fly   673 SLFYIAF-LKGKFVGYPAKYNRVLGFRQEECNPGGCLMELCMQ-LVIIMAGKQAVNAIVEMLIPY 735
            ||||||| ||.                          |:|..| |..::...|.:|.:||.|:||
Mouse   415 SLFYIAFVLKD--------------------------MKLLRQSLATLLITSQILNQVVESLLPY 453

  Fly   736 -LMRTF-KELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNS---LYVEYLEMVVQFGFITLF 795
             |.|.: ..:..:....||..|..|  |.|.     ||..|..:   .:.:|||:.:|||:::||
Mouse   454 WLQRKYCARVKRKVQALKSEVDTTL--YEQV-----LLEKEMGTYLGTFDDYLELFLQFGYVSLF 511

  Fly   796 SLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAF 860
            |..:|||...|:|||..||..||:||.|..:||....:..||||......::.|:|.::..:|..
Mouse   512 SCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGM 576

  Fly   861 STNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPH 925
            |               |::|       |||                              ||..
Mouse   577 S---------------PQVN-------AVF------------------------------PESK- 588

  Fly   926 PYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQ 990
                        |..:..:|..::.:..|:.||.:|:||....:.:::.|         :|:|..
Mouse   589 ------------TDLVLIVVAVEHALLALKFILAFAIPDKPRHIQQKLAR---------LEFESL 632

  Fly   991 HAMK 994
            .|:|
Mouse   633 EALK 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	10/39 (26%)
		Anoctamin	395..976	CDD:461349	145/591 (25%)
Ano10	NP_001408476.1	Anoctamin	200..626	CDD:461349	145/590 (25%)