DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano3

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_031756440.1	Gene:	ano3 / 100495805	XenbaseID:	XB-GENE-1012403	Length:	983	Species:	Xenopus tropicalis

Alignment Length:	1018	Identity:	336/1018 - (33%)
Similarity:	513/1018 - (50%)	Gaps:	173/1018 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RQSTALEHLNGGGGGGGDHTDAAIAAQMIALQNG-------RNHLPTGIGVTGDGGQGGGDDEVS 151
            :..|..:|||       .||......|...:..|       :|...|....|.|...|..|....
Frog    42 QSQTDPQHLN-------KHTTVQNRVQPQPVSEGATESDLEQNRDSTKDTYTDDSEHGAYDSRTD 99

  Fly   152 RRLL----------------RTSSNISNKDK----KLPITYSQWKSRTYRR----FDDGKRSVDF 192
            :.||                ::..::.||:|    :.|....|.:..|...    |.||.:.:|:
Frog   100 QSLLIQHKLTRQKQGSRKSQKSKEDLLNKEKHIFERFPTAPVQDEVGTVASLGLFFKDGMKRIDY 164

  Fly   193 VLAY-NGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIK 253
            :|.| ....|||    |...||.||:.|||.||....   ..:.|:|||.|.:.|.:|||.:.|:
Frog   165 ILVYKKSSAQLE----KRSTFEKNLRAEGLMLEREHAITNNDIMFVKIHCPWDTLCKYAERMNIR 225

  Fly   254 VPLKPIPGQDQIFAESAHEFKTCFSRMCKS-LFSSVQLNTALFPEREPRIHLEFSRNYL-ELYDT 316
            :|.:                |.|:....:| ...|:|.|........||..::..:..| :|.:|
Frog   226 MPFR----------------KKCYYTDWRSKTMGSLQRNMRQLKSWLPRNPMKLDKEALPDLEET 274

  Fly   317 E------------------HPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTC 363
            :                  ...|...|||..|::.:|||.::.:|:   ..:||.:|:.:|.|..
Frog   275 DCYTAPFSRARMHHFTINNKDTFFSNSTRSRIVHHVLQRTKYEDGK---SKMGISRLLSNGTYEA 336

  Fly   364 AYTLHD--------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYT 414
            |:..|:              ::.|..|.:.||....|...||||.|:.|||.|:.|||||||:||
Frog   337 AFPPHEGSYKSRHPIKTHGAQNHRHLLYERWARWGMWYKYQPLDLIRRYFGEKIGLYFAWLGWYT 401

  Fly   415 QMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLID 479
            .||||.::.|:..||||..|.:|..:|::||:.|.|||||.|:::|...||||:|..:|..:|.|
Frog   402 GMLIPAALVGLFVFLYGLFTMDSSQVSKEICEANETIMCPMCEKNCSLQRLNESCIYAKVTHLFD 466

  Fly   480 NNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYE 544
            |..||.||..|||||.|:||||||..|.|.:.|.|..:....|..|||:.|:.|:.:::
Frog   467 NGGTVFFAIFMAIWATVFLEFWKRRRAVLTYDWDLIDWEDEEEELRPQFEAKYSQLERV------ 525

  Fly   545 QDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVI--AIAGIIIYR---MAQRASHSILG 604
            ...|||     |: ||..|....:....|:..:|..||::  |:..:::||   |.|.||.:...
Frog   526 NPITGK-----PE-PFQPFSDKLSRLMVSVSGIFFMISLVLTAVFAVVVYRLVAMEQFASFNWHF 584

  Fly   605 SENSMTFKVMILPMTAG---IIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQ 666
            .:....|      .|:|   .|:.::|..|::||..:|..|||.|:.||.:|::.|..:|.::||
Frog   585 IKKYWQF------ATSGTGVCINFMIIMSLNVVYEKVAYLLTNLEHPRTDSEWENSFALKMFLFQ 643

  Fly   667 FVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVE 730
            |||..||:|||||..|:|.|.|.||||:. .:|.|||:|.|||::||:|:.:||..||..|..:|
Frog   644 FVNLNSSIFYIAFFLGRFAGRPGKYNRLFQRWRLEECHPSGCLIDLCLQMGVIMVLKQMWNNFME 708

  Fly   731 MLIPYLMRTFKELSYRHGWY---KSHQDQRLVPYNQFT-----EDYNLLPAENNSLYVEYLEMVV 787
            :..|.|          ..|:   |.....::|. |:||     :|:||.|...:.|..||||||:
Frog   709 LGYPLL----------QNWWSRRKIKNSGQMVE-NKFTLPQWEKDWNLQPMNAHGLMEEYLEMVI 762

  Fly   788 QFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVA 852
            ||||.|:|..|||||||||||||:||:||||.|.:...|||:..||.|||:|:.|:..:..:||.
Frog   763 QFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPMPARATDIGIWYGILEGIGVLAVI 827

  Fly   853 SSAMIIAFSTNLIPKIVYAASMG---------DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVN 908
            ::|.:||.:::.||:.|||...|         :..|..|:|.:|::|:.|:      ||...
Frog   828 TNAFVIAITSDYIPRFVYAFKYGPCLDEGYRHEKCLQGYVNSSLSIFDLKE------LGQGY--- 883

  Fly   909 ETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRI 973
            ...|||.::|..|...:||:..:.:|.:|..|||||:::::::..::..:.:.:||:...|..|:
Frog   884 SGYCRYRDYREPPWSSNPYEFTLQFWHVLAARLAFIIVFEHLVFGIKSFIAYLIPDMPKDLCDRM 948

  Fly   974 KRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNE 1016
            :||.:|::|.:.|.|.:|        |..::|..|  :..|:|
Frog   949 RREKYLVQEMMYEAELEH--------LQRERKKNG--KHYNHE 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	63/246 (26%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	237/607 (39%)
ano3	XP_031756440.1	Anoct_dimer	154..379	CDD:406563	63/247 (26%)
ano3	XP_031756440.1	Anoctamin	382..951	CDD:398306	236/606 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050