Protein Alignment CG10353 and ano8

DIOPT Version :9

• Sequence 1: NP_001245633.1
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_004911073.1
• Gene: ano8 / 100491780
• XenbaseID: XB-GENE-6044545
• Length: 1121
• Species: Xenopus tropicalis
• Alignment Length: 1133
• Identity: 245/1133 - (21%)
• Similarity: 385/1133 - (33%)
• Gaps: 435/1133 - (38%)

  Fly   127 GRNHLPTGIGVTGDGGQGGG----DDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGK 187
            |:...|.|......|.|.|.    |....:|||:....|:        ::..| .||.     ..
 Frog     9 GKKAQPEGERAEPAGSQHGTTGVLDKLFGKRLLQAGRYIT--------SHKSW-MRTV-----PT 59

  Fly   188 RSVDFVLAYNGETQLEEHRRKCEIFEANLQREGL-----QLEHNKVQRVHFIKIHAPAEVLYRYA 247
            .:.|.|:.::..|  ::|..   ::..|..|.||     |:.|::...::...:.|..|.|.|.|
 Frog    60 ENCDVVMTFSDNT--DDHTL---LWLLNHVRLGLPELIMQIRHHRHTGIYAFFVTATYENLLRGA 119

  Fly   248 EILKIKVPLK-PIPGQDQIFAESAHEFKTCFSRMCKS--LFSSVQLNTALFPEREPRIHLEFSRN 309
            |.:.::.|:| ...|..::|:             |:.  ::.:::.....|..:|
 Frog   120 EEIGLRKPVKAEFGGGTRVFS-------------CEEDYIYQNIENELIFFTSQE---------- 161

  Fly   310 YLELYDTEHPNFLDASTRYSIINFILQRQR-----------FVEGEETADNLGIEKLVQDGVYTC 363
                             |.|||.:.::..|           |:||:..     |.:|...||...
 Frog   162 -----------------RQSIIRYWMENLRAKQGESLHNIHFLEGQPI-----IPELTARGVIQQ 204

  Fly   364 AYTLHDKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCF 428
            .:.:|::....||::.|......|  ||||:|.||||.|||:||:|:||||..|:..:|||::.:
 Frog   205 VFPIHEQRILSRLMRSWVQAICEK--QPLDEICDYFGVKVAMYFSWMGFYTSSLVYPAVFGMMLW 267

  Fly   429 LYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIW 493
            :   || .||..|||||                       |              ||||....:|
 Frog   268 M---IT-ESDQTSRDIC-----------------------C--------------VVFALFNVVW 291

  Fly   494 AVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQY--LARISRTKKLAGKAYEQDHTGKRTILD 555
            |.::||.|||..|.|.::|| |......:|.||||:  :.|||.........|
 Frog   292 ATLFLEGWKRRGAELAYKWGTLDTPAEFIEEPRPQFRGVKRISPVTNCEEFYY------------ 344

  Fly   556 PDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPMTA 620
               |.|......:|.|..:.|..:|.       :.:..:|.......:.|...:...|...|.
 Frog   345 ---PPWKRLLFQSFVSLPVCVSCLCF-------VFVVMLACFELQEFILSIKELPRVVRFFPK-- 397

  Fly   621 GIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAF------ 679
             |:..:::|..|.||..:|..|.:.|..|.|:.|::.|.||..:|||||.|.|||||.|
 Frog   398 -ILLAVIVSSCDEVYRKIAYWLNDMENYRLQSAYEKHLIIKIVLFQFVNSYLSLFYIGFYLKDME 461

  Fly   680 -LKGKF--VGYPAKYNR-----VLGFRQEE-----------CNPGGCLMELCMQLVIIMAGKQAV 725
             ||..|  :..|..:.|     :|.|...:           .....||.:..| |..::..:|.:
 Frog   462 RLKELFLVLSLPHSFTRQVKDALLPFLSLQFHLFLIVLRALLRSAWCLFKSKM-LATLLVIRQFL 525

  Fly   726 NAIVEMLIPYLMRTFK--ELSYRHGWY-------------------------------------- 750
            ..:.|:..|:|.:..:  ||:.|..|.
 Frog   526 QNVKEVSQPHLYQKLQRGELTPRSVWLFVRYALKRLFQKYSLPQHPLRTPGNPMETGAGGRKKCL 590

  Fly   751 ------------------------------------------KSHQDQRLVPY------------ 761
                                                      :..:|..|||.
 Frog   591 NGGCGVPEEEEGVVSEDEEEEEEESIMDCGLKLKRVSFLEKGERREDVGLVPQQEDEGAFLQEGS 655

  Fly   762 ----------------------------------------------------------NQFTEDY 768
                                                                      .|..||.
 Frog   656 PTLMERGSDPASVFQLEDEEDEEQEGASGGVLQEGLEQESGVKLRQHRRRRKRVILEEEQSREDE 720

  Fly   769 N------------LLPAENN------------------SLYVEYLEMVVQFGFITLFSLAFPLAP 803
            .            :.|.|:|                  ..:.:|.||.||||::.|||.|||||.
 Frog   721 EDDTEMKQKRESWIDPPEDNYPTKLSQAEVESCMKKYEDTFNDYQEMFVQFGYVVLFSSAFPLAA 785

  Fly   804 LLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKI 868
            :.||:||:||:|.||.|:...|:||.|.|...||.|.::|..:..||:                |
 Frog   786 VCALINNIIEIRSDAFKLCTGLQRPFGRRVDGIGQWQNVMEAMGVIAI----------------I 834

  Fly   869 VYAASMGD-PELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMI 932
            |....||. .:|...|               |.||                  ||.
 Frog   835 VNCYLMGQCGQLQRLL---------------PWLG------------------PET--------- 857

  Fly   933 YWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQ 997
                   .:.|||:.::...:|:.|:...:||:.|.:.:.:.:..:..||...::|:|...:..|
 Frog   858 -------TIIFIVVLEHFALLLKYIIHVVIPDIPGWVAEEMAKLEYQRREAFKKHERQAQHRYQQ 915

  Fly   998 TELNGQQKSEGELRQRNNETVIRNRDEA 1025
            .:   ::|.|.|.|||:.:...|...|:
 Frog   916 QQ---RRKREEEERQRHADYHARKERES 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	41/227 (18%)
		Anoctamin	395..977	CDD:282414	174/792 (22%)
ano8	XP_004911073.1	Anoctamin	234..>470	CDD:282414	93/301 (31%)
		Anoctamin	<760..895	CDD:282414	55/199 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010