DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano5

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_031756250.1	Gene:	ano5 / 100489787	XenbaseID:	XB-GENE-5952827	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	899	Identity:	334/899 - (37%)
Similarity:	504/899 - (56%)	Gaps:	96/899 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 TSSNISNKDKKLPITYSQWKSRTYRRFD------------DGKRSVDFVLAYNGET-----QLEE 204
            |.|.:....:.|..|.|.:....::|.|            ||.|.:||||:|..:|     :..|
Frog    48 TDSELPGNSEGLSSTESTFLISNHQRIDKHAQSKDSVFFWDGSRRIDFVLSYTEDTGKDAEKKAE 112

  Fly   205 HRRKCEIFEANLQREGLQLE-----HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQ 264
            .||:   ||.|||:.||:||     .::..:.:|:|||||.|||..|||:|.:|:|||    .|.
Frog   113 RRRE---FELNLQKSGLELETEDKKESENGKTYFVKIHAPWEVLTTYAEVLNLKMPLK----ADD 170

  Fly   265 IFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDT-EHPNFLDASTRY 328
            :..:|    :...|.:.| ||...|  ..::||.: .....|.::..||:.| |...|...|||.
Frog   171 LKDDS----ENILSHVLK-LFKLPQ--EVMYPEPD-YFTAPFRKDKQELFRTEEREKFFTPSTRN 227

  Fly   329 SIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD------KDDRD----RLLKEWANI 383
            .|:.:||.|..:.| ||.....||::|:.:|.|..||.|||      .|:|:    .|...||..
Frog   228 RIVYYILSRCHYGE-EEGKKKFGIKRLLTNGSYLDAYPLHDCQYWKKTDERNCERYTLYTHWAKF 291

  Fly   384 SKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDN 448
            :::...||||.|:.|:|.|:.:|||||||||:||...:|.|..|||||:||.:....|::|||.|
Frog   292 TRFYKEQPLDLIRKYYGEKIGIYFAWLGFYTEMLFYAAVVGFFCFLYGWITMDDSISSKEICDPN 356

  Fly   449 ---GTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVH 510
               ..||||.||:.|::||||.||..|:::::.||..|:.||..|.||..::||||||..|.|.:
Frog   357 IGGQIIMCPLCDKRCEFWRLNSTCEPSQYSHMFDNVATLFFAIFMGIWVTLFLEFWKRRQARLEY 421

  Fly   511 RWGLTGFTHHVE--HPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPN-FTSY 572
            .|.|..|....:  ..||:|.::.:..|| .....|.:...|:|         :..||.. |..:
Frog   422 EWDLVDFEEEQQQLQLRPEYESKCTEKKK-NPVTQENELVIKQT---------ACNFLAKMFWCW 476

  Fly   573 SIMVLFICISVIAIAGIIIYRM-AQRASHSILGSENSMTFKV---MILP-----MTAGIIDLIVI 628
            ..::.:|.:.:.:|..||:||: ...|..||:  :|::..|.   ::.|     :||.:::.:.|
Frog   477 MSVLFWIALIIASIIAIIVYRLWVYAAFASIM--DNNLALKPVSNLLTPQLATSVTASVLNFVTI 539

  Fly   629 SLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNR 693
            .:|:.:|..:|:.:|:.|..||..||:..||:|.::|||||||||.||:||.|||||||||.|:.
Frog   540 MILNFLYERVAIWITDMEIPRTHLEYENRLTMKMFLFQFVNYYSSCFYVAFFKGKFVGYPADYSY 604

  Fly   694 VLG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQR 757
            :.| :|.|||:|.|||:||..||.|:|||||....|.|..:|:.....|....|      :..|.
Frog   605 LFGKWRNEECDPAGCLIELTTQLTIVMAGKQIWGNIQEAFVPWTWNWLKRRKAR------NHPQN 663

  Fly   758 LVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKML 822
            |  |:::..|.:|.......|:.|||||||||||||||..:||||||||||||::|:|:|:.|:.
Frog   664 L--YSRWEHDGDLQTFGGLGLFNEYLEMVVQFGFITLFVASFPLAPLLALLNNILEIRVDSWKLT 726

  Fly   823 RFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPE---LNNYLN 884
            ...:|||..:|..||||..|:..:..::|.::|.|:||::::||::||..:....|   ::.|:.
Frog   727 TQFKRPVAAKAHSIGVWQEILNGIAILSVVTNAFIVAFTSDMIPRLVYYYAYSQDEGTPMSGYIG 791

  Fly   885 FTLAVFNTKDFQVQ--PLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIY 947
            .:|:|||..||:.|  |:   ...:|...|||.::|..|.....|:..|.||.||..::|||:|.
Frog   792 SSLSVFNVSDFKEQSMPM---ENDMNVISCRYRDYRYPPGHEKEYQVTMQYWHILAAKMAFIIIM 853

  Fly   948 QNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELN 1001
            ::::.:::..:.|.:|||...:..|:|||.||.::.:.|||.:   ||.|...|
Frog   854 EHVVFLVKFFVAWLIPDVPSEVKARVKREKFLTQKILHEYELE---KLKQKLCN 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	80/241 (33%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	235/602 (39%)
ano5	XP_031756250.1	Anoct_dimer	85..300	CDD:406563	79/230 (34%)
ano5	XP_031756250.1	Anoctamin	303..882	CDD:398306	234/601 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110