Protein Alignment CG10353 and ano4

DIOPT Version :9

• Sequence 1: NP_001245633.1
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_004912950.2
• Gene: ano4 / 100488512
• XenbaseID: XB-GENE-6039527
• Length: 1157
• Species: Xenopus tropicalis
• Alignment Length: 1092
• Identity: 349/1092 - (31%)
• Similarity: 564/1092 - (51%)
• Gaps: 182/1092 - (16%)

  Fly    15 SEMDERESLYFDTISLAESEAAAAAAAHRKSISQSRNTIYHSAVDLAGDEGGGGSGGGRLRL-GG 78
            ::||...||...| ||:...|.:.::: :.::||..:.....::.:.|.:       .:|:: ..
 Frog   151 AQMDLSASLSCPT-SLSVIPAVSRSSS-QDTLSQDSDINQGISISIHGSK-------NQLQIHQK 206

  Fly    79 GAAAEHAALAWQ--------PGYRQSTALEHLNGGGGGGGDHTDAAIAAQMIALQNGRNHLP--- 132
            |:.|.|:....|        |..|::..:|                 |:...||.||...:.
 Frog   207 GSVASHSLPNEQTVVGHSSLPPLRKAIKME-----------------ASGKCALSNGNTEIQYPG 254

  Fly   133 -TGIGVTGDGGQGGG-----DDEV--SRRLLRTSSNISNKDKKLPITYSQWKSRTYRR-FDDGKR 188
             ..|.:..|..:...     ||.:  :..|...|..:|..|.:..:..:..|::|... |:||||
 Frog   255 VKDINIFFDDLEAANSPSKDDDSLLHAGNLTSMSDEVSRLDAEGEVLSAPEKNKTSGLFFNDGKR 319

  Fly   189 SVDFVLAYNGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEIL 250
            .:|::|.|. :|.|:..:|  ||||.|::.|||.||....   ..:.|:|:|||.|||.||||::
 Frog   320 RIDYILVYR-KTSLQSEKR--EIFERNIRAEGLHLEKESSIVNSDIIFVKLHAPWEVLGRYAELM 381

  Fly   251 KIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLE---------- 305
            .:::|.:    :...:....::|   .|||.|.|    .....|.|::..|:..|
 Frog   382 NVRMPFR----RKIYYLHRRYKF---MSRMEKQL----SRFRGLLPKKPMRLDKEKIPDLEENDC 435

  Fly   306 ----FSRNYLELY-----DTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVY 361
                ||:..:..:     ||    |.:.:||..|::.||||.::.||:   :.:|:.:|:.:..|
 Frog   436 YTAPFSQQRIHHFIINNKDT----FFNNATRTRIVHHILQRVKYEEGK---NKIGLNRLLTNCTY 493

  Fly   362 TCAYTLHD--------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGF 412
            ..|:.||:              ::.|..|.:.||:...|...||||.::.|||.|:.|||||||:
 Frog   494 EAAFPLHEGSYRSKNSIKTHGAENHRHLLFECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGW 558

  Fly   413 YTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYL 477
            ||.||.|.::.|:..||||..|.:|..:||:||......|||.||:.|.|.||:::|..:|..:|
 Frog   559 YTGMLFPAAIVGLFVFLYGMFTLDSCQVSREICQATNITMCPLCDKYCPYMRLSDSCIYAKVTHL 623

  Fly   478 IDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARIS---RTKKLA 539
            .||:.||.||..||:||.|:||||||..|.:.:.|.|..:....|..|||:.|:.|   |...::
 Frog   624 FDNSATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERVNPIS 688

  Fly   540 GKAYEQDHTGKRTILDPDVPFWSF--KFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHS- 601
            ||              |: |:.:|  |......|.|.:...||:.:.|:.||:|||:...::.:
 Frog   689 GK--------------PE-PYQAFADKCSRLVVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAA 738

  Fly   602 ---ILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNY 663
               .|...||.    :....||..|:..:|.||:::|..:|:.|||.|..||::|::.|.|:|.:
 Frog   739 FKWALIRNNSQ----VATTGTAVCINFCIIMLLNVLYERVALFLTNLEQPRTESEWENSFTLKMF 799

  Fly   664 VFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNA 727
            :|||||..||.|||||..|:|.|.|..|.|::. :|.|||:|.|||::||:|:.|||..||..|.
 Frog   800 LFQFVNLNSSTFYIAFFLGRFTGRPGAYLRLINKWRLEECHPSGCLIDLCLQMGIIMVLKQTWNN 864

  Fly   728 IVEMLIPYLMR--TFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFG 790
            .:|:..|.:..  |.::|...||.:    .:..:|  |:.:||||.|.....|:.|||||::|||
 Frog   865 FMELGYPLIQNWWTRRKLRQEHGIH----GKTALP--QWEKDYNLQPINPYGLFEEYLEMILQFG 923

  Fly   791 FITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSA 855
            |.|:|..|||||||||||||:||:||||.|.:...|||:..||:|||:|:.|:..:..::|.::|
 Frog   924 FTTIFVAAFPLAPLLALLNNIIEIRLDAYKFITQWRRPLASRAKDIGIWYGILEGIGILSVITNA 988

  Fly   856 MIIAFSTNLIPKIVYA---------ASMGDPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNET- 910
            .:||.:::.||::|||         ...|:..:..|:|.:|:||...||:        .|.|.:
 Frog   989 FVIAVTSDFIPRLVYAYKYGPCAGQGRAGEKCMVGYVNASLSVFLVTDFE--------NHSNSSR 1045

  Fly   911 -----------VCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPD 964
                       .|||.::|:.|..|.||...:.:|.:|..|||||:::::::..::.::.:.:||
 Frog  1046 NGREFAEQYVKYCRYRDYRDPPSAPEPYAYTLQFWHVLAARLAFIIVFEHLVFFIKHLISYLIPD 1110

  Fly   965 VSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNE 1016
            :...|..|::||.:|::|.:.|.|.:...|         :|.|   |::|.:
 Frog  1111 LPKDLRDRMRREKYLIQEMMYEAELERVQK---------EKKE---RKKNGK 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	70/244 (29%)
		Anoctamin	395..977	CDD:282414	232/614 (38%)
ano4	XP_004912950.2	Anoct_dimer	313..538	CDD:406563	70/245 (29%)
		Anoctamin	541..1122	CDD:398306	231/613 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040