DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano6

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_002932853.1	Gene:	ano6 / 100486935	XenbaseID:	XB-GENE-982324	Length:	909	Species:	Xenopus tropicalis

Alignment Length:	904	Identity:	335/904 - (37%)
Similarity:	500/904 - (55%)	Gaps:	117/904 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 TSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYNGETQLEEH---------RRKCEIF 212
            :::.|...|:.|...|          |.|.:|.:|:||.|..|| ::||         ::|.:.:
Frog    47 SAAEIVEFDENLDSLY----------FTDNQRRIDYVLVYEDET-MKEHIAKKSFLKQKKKRQAY 100

  Fly   213 EANLQREGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFK 274
            |:||.:.||.||..:.   .::.|:|:|||.|||..|||::.||:||:|   .|....:||.
Frog   101 ESNLIKSGLHLEATRSVSDGKIIFVKVHAPWEVLCTYAEVMHIKLPLQP---NDLRKHQSAF--- 159

  Fly   275 TCFSRMCKSLFSSVQLNTALF--PEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQR 337
            .||:::.:.....::.....|  |..:.||.        :.|..:...|...:||..|::|||.|
Frog   160 NCFTKIFRVSEDIIKPEQEFFTAPFEKDRID--------DFYIQDKETFFTPATRSRIVHFILSR 216

  Fly   338 QRFVEGEETADNLGIEKLVQDGVYTCAYTLHD------------KDDRDRLLKEWANISKWKNLQ 390
            ..:.. :|.....||.||:..|:|..|:.|||            ..:|..|.|:||:.......|
Frog   217 VEYAI-KENVKKFGINKLLDSGIYKAAFPLHDCNFNAVSVDSRCPSERYILYKQWAHPFSILKFQ 280

  Fly   391 PLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGF-----ITWNSDPISRDICDDN-- 448
            |||.::.|:|.||.:|||||||||:|||..:|.||.|||||.     .||     |:::||.:
Frog   281 PLDLVRKYYGEKVGIYFAWLGFYTRMLIVAAVVGVACFLYGVKSQETCTW-----SKEVCDPSIG 340

  Fly   449 -GTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRW 512
             ..|||||||::|:||.||.||.|||...:.|:..|:|||..|.||..::||||||..|.|.:.|
Frog   341 GSIIMCPQCDKACNYWYLNITCESSKKLCIFDSFGTLVFAVFMGIWVTLFLEFWKRRQAELEYEW 405

  Fly   513 GLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSF-KFLPNFTSYSIMV 576
            ....|....|.|.|:|.|:.:...|           .:.|..:..||:.:| |.|......|.:.
Frog   406 DTVEFLEQEEQPLPEYEAKCTHVVK-----------NRITQQEEHVPYTAFGKCLRVTCCTSAVF 459

  Fly   577 LFICISVIAIAGIIIYRMA---------QRASHSILGSENSMTFKVMILP-----MTAGIIDLIV 627
            .:|.:.|.::.|||:||::         .||    :...|....:..:.|     :||.||..|:
Frog   460 FWILLIVASVVGIIVYRLSVFLVFSATLPRA----VNGTNVEAIQKYLTPQTATTITASIISFII 520

  Fly   628 ISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYN 692
            |.||:|:|..:|:.:|::|..||:|||:.|||.|.::|||||||||.|||||.|||.||||....
Frog   521 IMLLNMLYEKVAIIITDFELPRTRTEYENSLTTKMFLFQFVNYYSSCFYIAFFKGKIVGYPGDPV 585

  Fly   693 RVLG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQ 756
            ...| :|.|||:|||||:||..||.|||.||...|.|.|:|:|::    |.|..|   .:|...:
Frog   586 YWFGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEILVPWV----KNLISR---CRSSGSK 643

  Fly   757 RLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKM 821
            .::|  ::..||.|.||....|:.||||||:||||:|||..:|||||:|||:||::|:|:||.|:
Frog   644 AVLP--RWEADYLLQPAGKLGLFYEYLEMVIQFGFVTLFVASFPLAPVLALVNNLLEIRVDAWKI 706

  Fly   822 LRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNN----- 881
            ....||.|..:|:|||.|..||..|..:||.::||||||::::||::||..|...|...|
Frog   707 TTQWRRMVPEKAQDIGAWQPIMEGVAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGNYTTNT 771

  Fly   882 ---YLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAF 943
               |:|.||:||:..|||.:.........|.|||||.:||..|...|.|:..:.||.::..:|:|
Frog   772 MQGYINNTLSVFSVSDFQSESKPVAVNWFNPTVCRYRDFRYPPGHEHQYEHSVYYWHVVAAKLSF 836

  Fly   944 IVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNG 1002
            :::.::|:..::.|:.:.:||||.....:||||.:|.::.:.|   :| :::::.::.|
Frog   837 LIVMEHIVYFVKFIIAYIIPDVSNETKDKIKREKYLTQKLLHE---RH-LRVMKKQMGG 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	70/234 (30%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	253/613 (41%)
ano6	XP_002932853.1	Anoct_dimer	62..282	CDD:374413	71/245 (29%)
ano6	XP_002932853.1	Anoctamin	285..869	CDD:367984	252/612 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020