DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and Ano2

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_008761521.2	Gene:	Ano2 / 100361584	RGDID:	1591606	Length:	979	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	355/979 - (36%)
Similarity:	511/979 - (52%)	Gaps:	137/979 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 GRNHLPTGIGVTGDGGQGGGDD------EVSRRLLRTSSNISNK--DKKLPITYSQWKSRTYRRF 183
            |..|....:.|.|....|..|:      :||||......::.|.  |...|.:.....||.:  |
  Rat     7 GPRHGQQYLKVPGPRLPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPASSEARLSRMH--F 69

  Fly   184 DDGKRSVDFVLAY----------------------NGETQLEEH-------------------RR 207
            .|.:|.||:||||                      ||||..|.|                   |.
  Rat    70 HDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDIELGPLDALEEERRE 134

  Fly   208 KCEIFEANLQREGLQLE---HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAES 269
            :.:.||.||...||:||   .:|.|...|::||||.:||.|.||.||||||.|.:
  Rat   135 QRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKM---------- 189

  Fly   270 AHEFKT------CFSRMCKSLFSSVQLNTALFPE----REPRIHLEFSRNYLELYDTEHPN-FLD 323
             :|.|.      .||.:.::|.|.:|...   ||    |...:...|||..:.||:.:..: |.|
  Rat   190 -YEIKAGGSIAKKFSAILQTLSSPLQPRV---PEHSNNRMKNLSYPFSREKMYLYNIQEKDAFFD 250

  Fly   324 ASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLH---------DKDDRDRLLKE 379
            .:||..|::.||:|........|   :||..|:.:.:|..||.||         |.:||..|.:|
  Rat   251 NATRSRIVHEILKRTACSRANNT---MGINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQE 312

  Fly   380 WANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDI 444
            ||....:...||:|.|:.|||.|:.|||||||.||..|||.||.||:.||||..|...|..|:::
  Rat   313 WARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEM 377

  Fly   445 CD-DNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGL 508
            || .|...|||.||:|||||.|:..|.:::.::|.||..||.|:..||:||.::||.|||....|
  Rat   378 CDHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRL 442

  Fly   509 VHRWGLTGFTHH----VEHPRPQYLARI----------SRTKKLAGKAYEQDHTGKRTILDPDVP 559
            .:.|.|||....    .||.||:|..::          |..:||...:.|.|..      |.|..
  Rat   443 GYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDED------DEDKL 501

  Fly   560 FWSFKFLPNFTSYSIMVLF-ICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPMTAGII 623
            .|..:| |.:...|:.:|| |.::...:.|:|:||:...|:.| |........:|.: ..||.||
  Rat   502 TWKDRF-PGYLMNSVSILFMIALTFSIVFGVIVYRITTAAALS-LNKATRSNVRVTV-TATAVII 563

  Fly   624 DLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYP 688
            :|:||.:||.:|..:|..||..|..:|:..::|.|.:|.::.:|||.||.:||:||.||:|||.|
  Rat   564 NLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRP 628

  Fly   689 AKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAV-NAIVEMLIPYLMRTFKELSYRHGWYK 751
            ..|..|. |:|.|||.|||||||||:||.|||.|||.: |.|.|:.:|.|.:.|::|.......:
  Rat   629 GSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGE 693

  Fly   752 SHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRL 816
            |..|....| .|:..||:|.|  ...|..||:||::||||:|||..:|||||:.|||||||||||
  Rat   694 SDPDHSKRP-EQWDLDYSLEP--YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL 755

  Fly   817 DAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMG-DPELN 880
            ||.|.:..||||..:|.:|||:|..|::.:.:.:|..:|.:||.:::.||::||..|.. :..|:
  Rat   756 DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLH 820

  Fly   881 NYLNFTLAVFNTKDFQVQPLLGGSQHVNE------TVCRYTEFRNSPEDPHPYKRPMIYWKILTG 939
            .::|.||:.||     |..|..|:|..|.      ..||:.::|..|..|:||:....||.:|:.
  Rat   821 GFVNHTLSFFN-----VSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSA 880

  Fly   940 RLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQ 1004
            ||||::|:||::..|..::.|.:||:...:..:||:|..||.:..:: |:...:||..   ...|
  Rat   881 RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLK-EEHEKVKLAD---EPAQ 941

  Fly  1005 KSEG 1008
            :|:|
  Rat   942 RSQG 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	83/272 (31%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	246/606 (41%)
Ano2	XP_008761521.2	Anoct_dimer	68..325	CDD:406563	83/275 (30%)
Ano2	XP_008761521.2	Anoctamin	328..917	CDD:398306	246/605 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23221
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920