DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano1

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001123799.1	Gene:	ano1 / 100170550	XenbaseID:	XB-GENE-5967576	Length:	979	Species:	Xenopus tropicalis

Alignment Length:	901	Identity:	322/901 - (35%)
Similarity:	499/901 - (55%)	Gaps:	103/901 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAY----------------------------------NGETQLE---------- 203
            |.||::.||::|||                                  .|...||
Frog    81 FRDGQKKVDYILAYTYKKSSGSRTPNKKNHHSNSVHSLHSTKDDHHLPGGAADLEAMEAEPKMDY 145

  Fly   204 ---EHRRKCEIFEANLQREGLQLEHNKVQRVH---FIKIHAPAEVLYRYAEILKIKVPLKPI--- 259
               :.|.:.|.:|.||...||:||.::..:.|   |:|||||..||.|.||.:|:|:|.|..
Frog   146 HEDDKRFRREEYEGNLIETGLELERDEETKQHGVGFVKIHAPWNVLCREAEFMKLKMPTKKFYQI 210

  Fly   260 ---PGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTA-LFPEREPRIHLEFSRNYLELYD-TEHP 319
               ||..|           ..|...:.:...:|...| |.|:....:...|||....|:| ::..
Frog   211 NQTPGLMQ-----------KLSSFIQKISEPIQPKVAGLRPQTVKPLSYPFSREKQHLFDMSDKD 264

  Fly   320 NFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHDKD--------DRDRL 376
            :|.|:.||.||:..||:|....:.:.   ::||..|:.:|||:.||.|||.|        ||..|
Frog   265 SFFDSKTRSSIVYEILKRTTCTKAKY---SMGITSLLANGVYSAAYPLHDGDYESEAEANDRKLL 326

  Fly   377 LKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPIS 441
            ..|||:.|.:...||:|.::.|||.|:.|||||||.|||||||.|:.|::.||||..|.:.|..|
Frog   327 CDEWASYSVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATVDEDIPS 391

  Fly   442 RDICDDNGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYS 505
            .::||:...| |||.|||:|:||:::..|.:::.::|.||..||.|:..||:||..::|.|||..
Frog   392 MEMCDNRYNITMCPLCDRTCNYWKMSSACGTARASHLFDNPATVFFSVFMALWAASFMEHWKRRQ 456

  Fly   506 AGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFT 570
            ..|.:||.||||....:|||.:|.|::  .:|...|.|....|.|..:.      |..:|....|
Frog   457 MRLNYRWDLTGFEEEEDHPRAEYEAKV--LQKSLKKEYRHKETEKEKLT------WRDRFPAYLT 513

  Fly   571 SYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPMTAGIIDLIVISLLDMVY 635
            :...::..|.::...:.|:|:||::..|:.::..:.|:.....:.:..||.||:|:||.:||.||
Frog   514 NVVGIIFMIGVTFAIVFGVIMYRISTAAALAMSSNPNTRANVRVTVTATAVIINLVVILILDEVY 578

  Fly   636 SNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQ 699
            ..:|..||..|..:|...::|.|..|.::.:|||.|:.:||:||.||:.||.|..|..:. .||.
Frog   579 GAIARWLTQIEVPKTDQTFEERLIFKAFLLKFVNAYTPIFYVAFFKGRIVGRPGDYYYIFQSFRM 643

  Fly   700 EECNPGGCLMELCMQLVIIMAGKQAV-NAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQ 763
            |||.|||||||||:||.|||.|||.: |.:.|:.||.:.:..:.|..:...||.| ::.|....:
Frog   644 EECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKSKRQSYKDH-EEHLKKKQR 707

  Fly   764 FTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRP 828
            :.|||:|.|..  .|..||:||::||||:|||..:||||||.|||||:||:||||.|.:..||||
Frog   708 YEEDYDLEPFA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFITELRRP 770

  Fly   829 VGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMG-DPELNNYLNFTLAVFNT 892
            |.:||:|||:|::|:..:.::||..:|.:|:|:::.||::||..... |..::.::|.||:.||.
Frog   771 VAVRAKDIGIWYNIIRGLGKLAVIINAFVISFTSDFIPRLVYLYMYSPDGTMHGFVNHTLSYFNV 835

  Fly   893 KDFQVQPLLGGSQHVN----ETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITM 953
            .||  :|....|:.|:    ..:|||.::|.:|..||.|.....||.:|..||||::::||::..
Frog   836 TDF--KPGTEPSEPVDLGYKVELCRYKDYREAPWSPHKYDINKDYWAVLAARLAFVIVFQNLVMF 898

  Fly   954 LQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGE 1009
            :...:.|.:||:...:.::|.||..|:.|..:: |:|..:::::| ....::.:||
Frog   899 MSDFVDWIIPDIPKDISEQIHREKVLMVEVFLK-EEQGKLQMLET-WKEHERRKGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	78/274 (28%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	234/589 (40%)
ano1	NP_001123799.1	Anoct_dimer	80..342	CDD:374413	78/274 (28%)
ano1	NP_001123799.1	Anoctamin	345..921	CDD:367984	233/588 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110