DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1847 and SPAG1

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_016869243.1	Gene:	SPAG1 / 6674	HGNCID:	11212	Length:	961	Species:	Homo sapiens

Alignment Length:	339	Identity:	71/339 - (20%)
Similarity:	126/339 - (37%)	Gaps:	90/339 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YIELTPGTRVKF---HFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKLEVWELI----------- 73
            |.|||     :|   |.|.       :..:||.:.|.........|..|.||.|
Human    89 YPELT-----EFCEKHLQA-------LAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEI 141

  Fly    74 ---VQQMSLNEVAKFTVHKSLCAQYPFI--SKTLRDIGKKPEERRHCCGMTLQNEGIGYTDLDEL 133
               ..:|..:|...|...|.   ..|.:  |.:...:||:...:|    .|.:.....|.:.|
Human   142 KKEEDKMHFHETETFPAMKD---NLPPVRGSNSCLHVGKEKYSKR----PTKKKTPRDYAEWD-- 197

  Fly   134 LQNPSDLEFIIELFSIELPEQYEK----ERWQMSDDEKMLATSTL------------RERGNNFY 182
                   :|.:|...:::.|.|::    ::..:|..|..:.|:.|            :|:||..:
Human   198 -------KFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAF 255

  Fly   183 KASRFTEAETCYREAVGIVEQLMLKEKPHDEEWQELAAIKTPLLL-NYAQCRLIAGDFYAVIEHC 246
            .:..:.||...|..::                    :|:.|.:.. |.||..:...::.:..:.|
Human   256 NSGDYEEAVMYYTRSI--------------------SALPTVVAYNNRAQAEIKLQNWNSAFQDC 300

  Fly   247 NEVLTLDPRNVKALFRRAKAHAGAWNPAQARRDFLDALAL----DASLK--STVSKELKSIEDQQ 305
            .:||.|:|.|||||.|||..:.......:|..|....|.:    |.:.|  |.|.::||:.|...
Human   301 EKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAAS 365

  Fly   306 QARNVQDRIHMQKL 319
            :.:....|:.:|::
Human   366 ETQTKGKRMVIQEI 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	19/85 (22%)
		3a0801s09	150..>308	CDD:273380	40/180 (22%)
		TPR repeat	173..217	CDD:276809	7/55 (13%)
		TPR repeat	222..252	CDD:276809	7/30 (23%)
		TPR repeat	257..285	CDD:276809	9/27 (33%)
SPAG1	XP_016869243.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940