DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1847 and fkbp5

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_005166078.1	Gene:	fkbp5 / 368924	ZFINID:	ZDB-GENE-030616-630	Length:	477	Species:	Danio rerio

Alignment Length:	384	Identity:	85/384 - (22%)
Similarity:	143/384 - (37%)	Gaps:	110/384 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTRVKFHFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKLEVWELIVQQMSLNEVAKF-------- 85
            |.||..|: |.|....:..|.|...::|....:||...::.|::.|..|...||...
Zfish    74 GDRVFVHY-TGRLLSGKKFDSSLDRKEPFVFNVGKGQVIKAWDICVCSMQKGEVCLMLCKPEYAY 137

  Fly    86 -----------------------------------------------------TVHKSL---CAQ 94
                                                                 |||..|   |..
Zfish   138 GSAGSPPKVPPNSTLVFEIELLNFRGEELTEDGGIVRRIKVKGEGYSNPNEGATVHVHLEGWCGG 202

  Fly    95 YPFISKTL-------RDIG--------KKPEERRHCCGMTLQ------NEGIGYTDLDELLQNPS 138
            ..|.|:.:       .|:|        .:..::..||.:.|:      .||....|:.      |
Zfish   203 RLFDSRDVTFAVGESEDVGVPLGVDRAMEKLQKGECCLLYLKPKYAFGKEGRKEHDIG------S 261

  Fly   139 DLEFIIELFSIELPE-QYEKERWQMSDDEKMLATSTLRERGNNFYKASRFTEAETCYREAVGIVE 202
            :.|.   |:.:.|.: :..||.|:|...||:.....::::|..::||.|:..|...|:..|..:|
Zfish   262 NAEL---LYEVTLKDFEKAKETWEMDLKEKLERAVLVKQKGTQYFKAGRYNYAVIQYQRIVNWLE 323

  Fly   203 QLMLKEKPHDEEWQELAAIKTPLL---LNYAQCRLIAGDFYAVIEHCNEVLTLDPRNVKALFRRA 264
            ......|      ::|.||:..||   ||.|.|.|...::...:|:||:|:.|||.|.|||:||.
Zfish   324 MECGNGK------EQLQAIQALLLVAHLNLALCYLRLREYSQTVENCNKVMELDPENEKALYRRG 382

  Fly   265 KAHAGAWNPAQARRDFLDALALDASLKSTVSKELKSIEDQQQARNVQDRIHMQKLFXNI 323
            :|.......:.|..||...|.:::..::..|:.|..   |.:.|...:|  .:|::.|:
Zfish   383 EARLLRNEFSLALMDFKQVLQVNSFNRAARSQILIC---QHKIREHHER--DKKIYANM 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	20/126 (16%)
		3a0801s09	150..>308	CDD:273380	47/161 (29%)
		TPR repeat	173..217	CDD:276809	9/43 (21%)
		TPR repeat	222..252	CDD:276809	11/32 (34%)
		TPR repeat	257..285	CDD:276809	9/27 (33%)
fkbp5	XP_005166078.1	FKBP_C	69..159	CDD:278674	16/85 (19%)
		FkpA	<167..271	CDD:223619	18/112 (16%)
		TPR_11	291..372	CDD:290150	24/86 (28%)
		TPR repeat	292..320	CDD:276809	6/27 (22%)
		TPR repeat	340..370	CDD:276809	11/29 (38%)
		TPR_11	343..405	CDD:290150	23/61 (38%)
		TPR	343..374	CDD:197478	12/30 (40%)
		TPR repeat	375..403	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910