DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1847 and Fkbp5

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_006256284.1	Gene:	Fkbp5 / 361810	RGDID:	1309155	Length:	473	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	88/415 - (21%)
Similarity:	152/415 - (36%)	Gaps:	125/415 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKSDMKPIRKEILNPGNAYIELTP--GTRVKFHFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKL 67
            :|.| :.:.|.:...|.:  |.||  |.:|..|::.:.:...: .|.||...:|....|||...:
  Rat    44 TKKD-RGVLKIVKRVGTS--EETPMIGDKVYVHYKGKLSNGKK-FDSSRDRNEPFVFSLGKGQVI 104

  Fly    68 EVWELIVQQMSLNEVAKFTVHKSLC-AQYP----------------FISKTLRDIGKKPEERRHC 115
            :.|::.|..|...|:...     || .:|.                |....|.|.  |.|:....
  Rat   105 KAWDIGVSTMKKGEICHL-----LCKPEYAYGSAGSLPKIPSNATLFFEIELLDF--KGEDLFED 162

  Fly   116 CGM--TLQNEGIGYTDLDELLQNPS---------------------DLEFII------------- 144
            .|:  .::.:|.||:       ||:                     |:.|:|
  Rat   163 SGIIRRIKRKGEGYS-------NPNEGATVEVHLEGCCAGRVFDCRDVVFVIGEGEDHDIPIGID 220

  Fly   145 -ELFSIELPEQ----------------------------YE---------KERWQMSDDEKMLAT 171
             .|..::..||                            ||         ||.|:|...||:...
  Rat   221 KALEKMQREEQCILYLGPQYGFGEAGKPKFGIEPNAELMYEVTLKSFEKAKESWEMDTKEKLEQA 285

  Fly   172 STLRERGNNFYKASRFTEAETCYREAVGIVEQ---LMLKEKPHDEEWQELAAIKTPLLLNYAQCR 233
            :.::|:|..::|..::.:|...|.:.|..:|.   |..||....|.:. |||     .||.|.|.
  Rat   286 AIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFL-LAA-----FLNLAMCY 344

  Fly   234 LIAGDFYAVIEHCNEVLTLDPRNVKALFRRAKAHAGAWNPAQARRDFLDALALDASLKSTVSKEL 298
            |...::...:|.|::.|.||..|.|.|:||.:|.........|:.||...|.::...|: ...::
  Rat   345 LKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKA-ARLQI 408

  Fly   299 KSIEDQQQARNVQDRIHMQKLFXNI 323
            ...:.:.:..|.:||    :::.|:
  Rat   409 SVCQRKAKEHNERDR----RVYANM 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	17/70 (24%)
		3a0801s09	150..>308	CDD:273380	45/197 (23%)
		TPR repeat	173..217	CDD:276809	11/46 (24%)
		TPR repeat	222..252	CDD:276809	8/29 (28%)
		TPR repeat	257..285	CDD:276809	8/27 (30%)
Fkbp5	XP_006256284.1	FKBP_C	61..152	CDD:278674	21/96 (22%)
		TPR_11	284..364	CDD:290150	22/85 (26%)
		TPR repeat	285..313	CDD:276809	5/27 (19%)
		TPR_11	336..399	CDD:290150	21/67 (31%)
		TPR	336..367	CDD:197478	11/35 (31%)
		TPR repeat	336..362	CDD:276809	8/30 (27%)
		TPR repeat	367..397	CDD:276809	10/29 (34%)
		TPR_1	369..401	CDD:278916	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910