DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1847 and fkbp4

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_005173673.1	Gene:	fkbp4 / 321795	ZFINID:	ZDB-GENE-030131-514	Length:	450	Species:	Danio rerio

Alignment Length:	317	Identity:	76/317 - (23%)
Similarity:	135/317 - (42%)	Gaps:	57/317 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IRKEILNPGNAYIELTPGTRVKFHFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKLEVW-ELIVQ 75
            |.:.|:..|..|.:...|..|:...:  .:.:.|:.|:   .|...|:..|:...|.:. |..:|
Zfish   145 ITRRIITKGEGYTKPNEGATVEVWLE--GSHEDRVFDE---RELKFEVGDGENLGLPLGVEKALQ 204

  Fly    76 QMSLNEVAKFTVHKSLCAQYPFISKTLRDIGKKPEERRHCCGMTLQNEGIGYTDLDELLQNP-SD 139
            .|...|.|.||:                    ||:            .|.|....::....| :.
Zfish   205 AMEQGEEALFTI--------------------KPK------------YGFGTAGSEKYNIPPNAT 237

  Fly   140 LEFIIELFSIELPEQYEKERWQMSDDEKMLATSTLRERGNNFYKASRFTEAETCYREAVGIVEQL 204
            |::.|::.:.|    ..||.|:|:..||:..:..::|:|..::|..::.:|...|:..|..:|.
Zfish   238 LQYKIKMKAFE----KAKESWEMNTIEKLEQSVIVKEKGTQYFKEGKYKQAIVQYKRIVSWLEH- 297

  Fly   205 MLKEKPHDEEWQELAAIKTPLLLNYAQCRLIAGDFYAVIEHCNEVLTLDPRNVKALFRRAKAHAG 269
            ....:|.|||  :..|::....||.|.|.|...|....:|:|::.|.||..|.||||||.:|...
Zfish   298 ESSMQPDDEE--KAKALRLAAYLNLAMCYLKLQDANPALENCDKALELDANNEKALFRRGEALVV 360

  Fly   270 AWNPAQARRDFLDALAL---DASLKSTVSKELKSIEDQQQARNVQDRIHMQKLFXNI 323
            ......|:.||...:.|   :.:.||.:|...|.:.:|.:    :|:    :|:.|:
Zfish   361 MKEFDMAKVDFQRVIELYPANKAAKSQISICQKHMREQHE----KDK----RLYANM 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	16/69 (23%)
		3a0801s09	150..>308	CDD:273380	47/160 (29%)
		TPR repeat	173..217	CDD:276809	11/43 (26%)
		TPR repeat	222..252	CDD:276809	9/29 (31%)
		TPR repeat	257..285	CDD:276809	10/27 (37%)
fkbp4	XP_005173673.1	FKBP_C	38..129	CDD:278674
		ppisom_GldI	<153..249	CDD:132555	25/136 (18%)
		TPR repeat	269..293	CDD:276809	5/23 (22%)
		TPR_16	270..348	CDD:290168	23/80 (29%)
		TPR repeat	305..343	CDD:276809	13/39 (33%)
		TPR_11	316..379	CDD:290150	23/62 (37%)
		TPR_1	316..347	CDD:278916	11/30 (37%)
		TPR repeat	348..376	CDD:276809	10/27 (37%)
		TPR_1	349..381	CDD:278916	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910