DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1847 and FKBP8

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_036313.3	Gene:	FKBP8 / 23770	HGNCID:	3724	Length:	413	Species:	Homo sapiens

Alignment Length:	327	Identity:	81/327 - (24%)
Similarity:	124/327 - (37%)	Gaps:	69/327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IRKEILNPGNAYIELTPGTR-------VKFHFQTRRAGDSRIIDDSRKMEKPMELV--LGKKFKL 67
            :||:.|.||      .||:.       |..|.||.....:|:      .|:| |||  ||....:
Human   102 LRKKTLVPG------PPGSSRPVKGQVVTVHLQTSLENGTRV------QEEP-ELVFTLGDCDVI 153

  Fly    68 EVWELIVQQMSLNEVAKFTVHKSLC-----AQYPFISKTLRDIGKKPEERRHCCGMTLQNEGIGY 127
            :..:|.|..|.:.|.|..|.....|     ::.|:|          |.....|..:||:....|
Human   154 QALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYI----------PPHAALCLEVTLKTAVDG- 207

  Fly   128 TDLDELLQNPSDLEFIIELFSIELPEQYEKERWQMSDDEKMLATSTLRERGNNFYKASRFTEAET 192
                      .|||                   .::..|::...:..||.||..|:.:.|..|..
Human   208 ----------PDLE-------------------MLTGQERVALANRKRECGNAHYQRADFVLAAN 243

  Fly   193 CYREAVGIVEQLMLKEKPHDEEWQELAAIKTPLLLNYAQCRLIAGDFYAVIEHCNEVLTLDPRNV 257
            .|..|:..:......:...:||.| |..:|...|.|.|..:|....:.|.:..|:.||...|.|:
Human   244 SYDLAIKAITSSAKVDMTFEEEAQ-LLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNI 307

  Fly   258 KALFRRAKAHAGAWNPAQARRDFLDALALDASLKSTVSKELKSIEDQQQARNVQDRIHMQKLFXN 322
            |||||:.|..|.....::|......||.|:.|.| |:..||..:..:..|:...:....:|:. |
Human   308 KALFRKGKVLAQQGEYSEAIPILRAALKLEPSNK-TIHAELSKLVKKHAAQRSTETALYRKMLGN 371

  Fly   323 IS 324
            .|
Human   372 PS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	20/77 (26%)
		3a0801s09	150..>308	CDD:273380	41/157 (26%)
		TPR repeat	173..217	CDD:276809	11/43 (26%)
		TPR repeat	222..252	CDD:276809	9/29 (31%)
		TPR repeat	257..285	CDD:276809	9/27 (33%)
FKBP8	NP_036313.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		FKBP_C	113..202	CDD:278674	25/105 (24%)
		TPR_11	222..304	CDD:290150	22/82 (27%)
		TPR 1	222..255		9/32 (28%)
		TPR repeat	231..267	CDD:276809	7/35 (20%)
		TPR repeat	272..302	CDD:276809	9/29 (31%)
		TPR 2	273..306		9/32 (28%)
		TPR_11	274..338	CDD:290150	21/63 (33%)
		TPR 3	307..340		11/32 (34%)
		TPR	307..340	CDD:197478	11/32 (34%)
		TPR repeat	307..335	CDD:276809	9/27 (33%)
		TPR repeat	341..369	CDD:276809	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910