DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1847 and FKBP5

DIOPT Version :9

Sequence 1:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001139247.1	Gene:	FKBP5 / 2289	HGNCID:	3721	Length:	457	Species:	Homo sapiens

Alignment Length:	407	Identity:	89/407 - (21%)
Similarity:	153/407 - (37%)	Gaps:	109/407 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKSDMKPIRKEILNPGNAYIELTP--GTRVKFHFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKL 67
            ||.| :.:.|.:...||.  |.||  |.:|..|::.:.:...: .|.|....:|....|||...:
Human    27 SKKD-RGVLKIVKRVGNG--EETPMIGDKVYVHYKGKLSNGKK-FDSSHDRNEPFVFSLGKGQVI 87

  Fly    68 EVWELIVQQMSLNEVAKFTVHKSLC-AQYPFIS----------KTL---------------RDIG 106
            :.|::.|..|...|:...     || .:|.:.|          .||               .|.|
Human    88 KAWDIGVATMKKGEICHL-----LCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGG 147

  Fly   107 KKPEERRHCCGMTLQNEG--------------------IGYT-----------DLDELLQNPSDL 140
            .....:|...|.:..|||                    :.:|           .:|:.|:.....
Human   148 IIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQRE 212

  Fly   141 E-------------------FIIE-----LFSIELPEQYE--KERWQMSDDEKMLATSTLRERGN 179
            |                   |.||     ::.:.| :.:|  ||.|:|...||:...:.::|:|.
Human   213 EQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTL-KSFEKAKESWEMDTKEKLEQAAIVKEKGT 276

  Fly   180 NFYKASRFTEAETCYREAVGIVEQ---LMLKEKPHDEEWQELAAIKTPLLLNYAQCRLIAGDFYA 241
            .::|..::.:|...|.:.|..:|.   |..||....|.:. |||     .||.|.|.|...::..
Human   277 VYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFL-LAA-----FLNLAMCYLKLREYTK 335

  Fly   242 VIEHCNEVLTLDPRNVKALFRRAKAHAGAWNPAQARRDFLDALALDASLKSTVSKELKSIEDQQQ 306
            .:|.|::.|.||..|.|.|:||.:|.........|:.||...|.::...|: ...::...:.:.:
Human   336 AVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKA-ARLQISMCQKKAK 399

  Fly   307 ARNVQDRIHMQKLFXNI 323
            ..|.:||    ::: |:
Human   400 EHNERDR----RIYANM 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	16/70 (23%)
		3a0801s09	150..>308	CDD:273380	43/162 (27%)
		TPR repeat	173..217	CDD:276809	11/46 (24%)
		TPR repeat	222..252	CDD:276809	8/29 (28%)
		TPR repeat	257..285	CDD:276809	8/27 (30%)
FKBP5	NP_001139247.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..135	CDD:278674	22/99 (22%)
		TPR_11	267..347	CDD:290150	22/85 (26%)
		TPR 1	268..301		7/32 (22%)
		TPR repeat	268..296	CDD:276809	5/27 (19%)
		TPR 2	317..350		13/37 (35%)
		TPR_11	319..382	CDD:290150	21/67 (31%)
		TPR	319..350	CDD:197478	11/35 (31%)
		TPR repeat	319..345	CDD:276809	8/30 (27%)
		TPR repeat	350..380	CDD:276809	10/29 (34%)
		TPR 3	351..384		9/32 (28%)
		TPR_1	352..384	CDD:278916	9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..457
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910