Protein Alignment Nrd1 and STE23

DIOPT Version :10

• Sequence 1: NP_572757.2
• Gene: Nrd1 / 32143
• FlyBaseID: FBgn0030344
• Length: 1147
• Species: Drosophila melanogaster
• Sequence 2: NP_013493.2
• Gene: STE23 / 851105
• SGDID: S000004381
• Length: 1027
• Species: Saccharomyces cerevisiae
• Alignment Length: 1145
• Identity: 294/1145 - (25%)
• Similarity: 504/1145 - (44%)
• Gaps: 186/1145 - (16%)

  Fly    16 FHVRTKRRSPITQLAGVRAITYSSLCKMTDQVKYLDIPD-KSETDKKLYKTLLLGNGLHALIVSD 79
            |.||  |..|.|.|:  |..| ::...||...|..::.. |.:.|::.|:.:.|.|.|.||::.|
Yeast    31 FTVR--RFKPFTCLS--RYYT-TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQD 90

  Fly    80 PSPMPHDGFTTSESSSSKSTVSTSSSIISRSESTSSTSTDSESSEESSSEEGDEKLAACALLIDY 144
            |                                                 :.|:  ||.:|.::.
Yeast    91 P-------------------------------------------------KADK--AAASLDVNI 104

  Fly   145 GSFAEPTKYQGLAHFLEHMIFMGSEKYPKENIFDAHIKKCGGFANANTDCEDTLFYFEVAEKHLD 209
            |:|.:|....|||||.||::||||||:|.||.:.:::.|.||.:||.|..::|.::|||..:||.
Yeast   105 GAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLF 169

  Fly   210 SSLDYFTALMKAPLMKQEAMQRERSAVDSEFQQILQDDETRRDQLLASLATKGFPHGTFAWGNMK 274
            .:||.|:.....||..:::..:|.:||:||.::.||:|..|..||..||.....|:..|:.||::
Yeast   170 GALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIE 234

  Fly   275 SL----KENVDDAELHKILHEIRKEHYGANRMYVCLQARLPIDELESLVVRHFSGIPHNEVKAPD 335
            :|    |||  ...:...|.:..|..|.||.|.:|:..|..:|.|.......|..:.:|..:.|
Yeast   235 TLGTLPKEN--GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVP- 296

  Fly   336 LSSFNYKDAFKAEFHEQVFFVKPVENETKLELTWVLPNVRQYYRSKPDQFLSYLLGYEGRGSLCA 400
               ...:...:.|..:::..|:||::..|||:::.:|::.:::.|||.:.||:|:|:||.|||.|
Yeast   297 ---LYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLA 358

  Fly   401 YLRRRLWALQLIAGIDENGFDMNSMYSLFNICIYLTDEGFKNLDEVLAATFAYVKLFANCGSMKD 465
            :|::..||.:|.||    |..::...:.|.:.|.|||.|..:..:|:...|.|:::..|....|.
Yeast   359 HLKKLGWANELSAG----GHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKW 419

  Fly   466 VYEEQQRNEETGFRFHAQRPAFDNVQELV--LNLKYFPPKDILTGKELYYEYNEEHLKELISHLN 528
            ::.|.|......|:|.........|..|.  |...|.|...|| ...|..:|..:.|.:....|.
Yeast   420 IFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483

  Fly   529 EMKFNLMVTSRRKYDDISAYDKTEEWFGTEYATIPMPEKWRKLWEDSVPLPELFLPESNKYVTDD 593
            .....:.:.||.     ...|..|:|:||.|..:..|....|..:.....|.|.||..|::|:.:
Yeast   484 PENSRVTLISRS-----LETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTN 543

  Fly   594 FTLHWHSMGRPEVPDSPKLLIKTDTCELWFRQDDKFDLPEAHMAFYFISPMQRQNAKNDAMCSLY 658
            |.:......:|  .|.|.||:..|..:||:::||:|..|..::...|..|....:..|..:.:||
Yeast   544 FKVDKIDGIKP--LDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLY 606

  Fly   659 EEMVRFHVCEELYPAISAGLSYSLSTIEKGLLLKVCGYNEKLHLIVEAIAEGMLNVAETLD---- 719
            .::....:.:..|.|..|.|..|.:...:||.:...|:||||.:::....:|:.:.....|
Yeast   607 TQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEI 671

  Fly   720 ---------ENMLSAFVKNQRKAFFNALIKPKALNRDIRLCVLERIRWLMINKYKCLSSVILEDM 775
                     :|:|.....:|...::||:|..::              |....|.:....:..|.:
Yeast   672 LKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS--------------WSTAEKLQVFEKLTFEQL 722

  Fly   776 REFAHQFPKELYIQSLIQGNYTEESAHNVMNSLLSRL---NCKQIRERGRFLEDITVKLPVGTSI 837
            ..|.....:.:|.::||.||...|.|..| :||:..|   |...::.....|.  :..||.|.:.
Yeast   723 INFIPTIYEGVYFETLIHGNIKHEEALEV-DSLIKSLIPNNIHNLQVSNNRLR--SYLLPKGKTF 784

  Fly   838 IRCHAL-NVQDTNTVITNFYQIGPNTVRVESILDLLMMFVDEPLFDQLRTKEQLGYHVGATVRLN 901
            ....|| :.|:.|:.|.:..|:...:..:.::..|....:.||.||.|||||||||.|.::...|
Yeast   785 RYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNN 849

  Fly   902 YGIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQILRHLPQDEYEHTRDSLIKLKLVADLALST 966
            :|.|...|::.|:.   |..|:|.||..|.....|:||.:|::::|..:::|....|.....::.
Yeast   850 HGTANIRILIQSEH---TTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAE 911

  Fly   967 EMSRNWDEIINESYLFDRRRRQIEVLRTLQKDEIINFVIS-IDGDNMRKLSVQVIGHRPAGMPEP 1030
            |.:|....|....|.|..|:::.:::..:.|.::|:|..: |..:|..||.:.:
Yeast   912 ESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHL----------- 965

  Fly  1031 LCGEDTAKCASKSDDESESENDDDDDEDEEEEESSEEEEEEEKEKEGLKGEDEDDLFYSLENKLN 1095
                       ||..|::..|                                       ||:|:
Yeast   966 -----------KSQVENKELN---------------------------------------ENELD 980

  Fly  1096 IVFLPAKFNNAFIITDIEKFKDDQYVYPQQKTQPKEEDEL 1135
                .||:....:|.|:..||...:|.|.:  ||.::.|:
Yeast   981 ----TAKYPTGQLIEDVGAFKSTLFVAPVR--QPMKDFEI 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrd1	NP_572757.2	Ptr	55..1030	CDD:440648	264/998 (26%)
STE23	NP_013493.2	Ptr	66..1000	CDD:440648	277/1087 (25%)