Protein Alignment Nrd1 and nrd1a

DIOPT Version :10

• Sequence 1: NP_572757.2
• Gene: Nrd1 / 32143
• FlyBaseID: FBgn0030344
• Length: 1147
• Species: Drosophila melanogaster
• Sequence 2: XP_694205.1
• Gene: nrd1a / 565850
• ZFINID: ZDB-GENE-070912-417
• Length: 1091
• Species: Danio rerio
• Alignment Length: 1098
• Identity: 386/1098 - (35%)
• Similarity: 579/1098 - (52%)
• Gaps: 85/1098 - (7%)

  Fly    55 KSETDKKLYKTLLLGNGLHALIVSDPSPMPHDGFTTSE-SSSSKSTVSTSSSIISRSESTSSTST 118
            ||.:|.|.|:.:.|.|||.||::||.|.:  ||....| ...|:...:...:.....|..|...|
Zfish    50 KSPSDPKQYRYIELSNGLRALLISDLSGL--DGKAEDEDDEDSEEEEAEEEAEGEEEEGDSGEGT 112

  Fly   119 DSESSEESSSEE----------------GDEKLAACALLIDYGSFAEPTKYQGLAHFLEHMIFMG 167
            |.||.||..|::                |.||.:|.||.|..|||::|....|||||||||:|||
Zfish   113 DEESEEEGDSQDSDFEELDEESDQKKKKGSEKQSAAALCIGVGSFSDPNDLPGLAHFLEHMVFMG 177

  Fly   168 SEKYPKENIFDAHIKKCGGFANANTDCEDTLFYFEVAEKHLDSSLDYFTALMKAPLMKQEAMQRE 232
            |||||.||.|||.:||.||..||:||||.|:|.|:|..|....:||.:......|||.::|:.||
Zfish   178 SEKYPSENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKRFKEALDRWAQFFICPLMIEDAIDRE 242

  Fly   233 RSAVDSEFQQILQDDETRRDQLLASLATKGFPHGTFAWGNMKSLK-----ENVDDAELHKILHEI 292
            ..|||||:|.....|..|::.|..|||....|...|.|||.::||     :|::   ::|.|.|.
Zfish   243 VEAVDSEYQLAKPSDSHRKEMLFGSLAKPDHPMSKFCWGNAQTLKTEPKEKNIN---VYKRLREF 304

  Fly   293 RKEHYGANRMYVCLQARLPIDELESLVVRHFSGIPHNEVKAPDLSSFNYKDAFKAEFHEQVFFVK 357
            .|.||.|:.|.:.:|::..:|.||..|...||.:|:|....||.|  :..:.|:.....:::.|.
Zfish   305 WKRHYSAHYMTLAVQSKESLDTLEEWVREIFSQVPNNGQLKPDFS--DKLNPFETPAFNKLYRVV 367

  Fly   358 PVENETKLELTWVLPNVRQYYRSKPDQFLSYLLGYEGRGSLCAYLRRRLWALQLIAGIDENGFDM 422
            ||.....|.:||.||...::||.||..::::|:|:||.||:.:.|||:.|||.|..|..|.|||.
Zfish   368 PVRKVHALTITWALPPQEKHYRVKPLHYIAWLIGHEGTGSILSMLRRKCWALALFGGNSETGFDQ 432

  Fly   423 NSMYSLFNICIYLTDEGFKNLDEVLAATFAYVKLFANCGSMKDVYEEQQRNEETGFRFHAQRPAF 487
            |:.||:|:|.|.||||||:|..||....|.|:|:....|..:.:|||.|:.|...|.:..|....
Zfish   433 NTTYSIFSISITLTDEGFQNFYEVAHLVFQYLKMLQTLGPQQRIYEEIQKIEANEFHYQEQTDPI 497

  Fly   488 DNVQELVLNLKYFPPKDILTGKELYYEYNEEHLKELISHLNEMKFNLMVTSRRKYDDISAYDKTE 552
            :.|:::..|::.||.:|.|||.:|.:|:..|.:...::.|...|.||::.|.........   .|
Zfish   498 EYVEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQCPL---RE 559

  Fly   553 EWFGTEYATIPMPEKWRKLWEDSVPL-PELFLPESNKYVTDDFTLHWHSMGRPEVPDS--PKLLI 614
            :||||:|:|..:.:.||::|.....| |.|.||..||::..||.|.     ..:.||:  |..::
Zfish   560 KWFGTQYSTEDIEQHWREIWAKDFDLNPSLHLPAENKFIATDFALK-----TSDCPDTEYPVRIM 619

  Fly   615 KTDTCELWFRQDDKFDLPEAHMAFYFISPMQRQNAKNDAMCSLYEEMVRFHVCEELYPAISAGLS 679
            ..|...||:::|:||.:|:|::.|:.|||:.:::.||..:..|:..::..::.|..|.|..|.|.
Zfish   620 NNDRGCLWYKKDNKFKIPKAYVRFHLISPVVQKSPKNLVLFDLFVNILVHNLAEPAYEADVAQLE 684

  Fly   680 YSLSTIEKGLLLKVCGYNEKLHLIVEAIAEGMLNVAETLDENMLSAFVKNQRKAFFNALIKPKAL 744
            |.|...|.||::||.|:|.||.|:...|.:.:.:.:...|  :.|.|.:..:|.:||.||||:.|
Zfish   685 YKLVAGEHGLVIKVKGFNHKLPLLFNLIVDYLADFSAAPD--VFSMFAEQLKKTYFNILIKPEKL 747

  Fly   745 NRDIRLCVLERIRWLMINKYKC-LSSVILEDMREFAHQFPKELYIQSLIQGNYTEESAHNVMNSL 808
            .:|:||.:||..||..|.||:. |..:.::::.||...|..|||.:.|:|||.|...:...:..:
Zfish   748 GKDVRLLILEHSRWSTIQKYQAVLDGLSVDELMEFVSGFKSELYAEGLLQGNVTSTESMGFLQYV 812

  Fly   809 LSRLNCKQIRERGRFLEDITVKLPVGTSIIRCHALNVQDTNTVITNFYQIGPNTVRVESILDLLM 873
            ..:|..|::......|..: |:||....:.:..:||..|.|:.:|.:||.||..:|..::::||:
Zfish   813 TEKLQFKKLSVEVPVLFRV-VELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLV 876

  Fly   874 MFVDEPLFDQLRTKEQLGYHVGATVRLNYGIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQIL 938
            |.::||.||.|||||.|||||..|.|...|:.|:|:.|.:|.||...:.||.:||.|.....:.:
Zfish   877 MHMEEPCFDFLRTKETLGYHVYPTCRNTSGVLGFSVTVETQATKFNTELVETKIEEFLVSFGEKM 941

  Fly   939 RHLPQDEYEHTRDSLIKLKLVADLALSTEMSRNWDEIINESYLFDRRRRQIEVLRTLQKDEIINF 1003
            ..|..|.:.....:|:|||...|..|..|:.|||.|::.:.|:|||..|:|:.|:.:.|.|::|:
Zfish   942 NSLSDDAFRTQVTALVKLKGCEDTHLGEEVDRNWTEVVTQQYVFDRLSREIDALKLMTKAELVNW 1006

  Fly  1004 VISIDGDNMRKLSVQVIGHRPAGMPEPLCGEDTAKCASKSDDESESENDDDDDEDEEEEESSEEE 1068
            .:...|:..|||||.|:|:                        ...|||..:|        ....
Zfish  1007 FMEHRGEGNRKLSVHVVGY------------------------GVEENDPPND--------PHPG 1039

  Fly  1069 EEEEKEKEGLKGEDEDDLFYSLENKLNIVFLPAKFNNAFIITDIEKFKDDQYVYPQQK 1126
            ||||..|..|.||.....|....|.|..|         ..||||..|.....::|..|
Zfish  1040 EEEEASKMSLYGEVSKLTFLQASNLLASV---------STITDIRAFTQTLNLFPYHK 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrd1	NP_572757.2	Ptr	55..1030	CDD:440648	363/1000 (36%)
nrd1a	XP_694205.1	Ptr	47..1085	CDD:440648	384/1093 (35%)