DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP7 and PMA2

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_015289.1	Gene:	PMA2 / 856071	SGDID:	S000005957	Length:	947	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	162/755 - (21%)
Similarity:	273/755 - (36%)	Gaps:	208/755 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 RAIKHGTTNM---------DVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTP---PMLLI 492
            |..|:|...|         ..|:..|..|.:|...|.::||.|.:       :.|..   .:||:
Yeast   125 RRKKYGLNQMAEENESLIVKFLMFFVGPIQFVMEAAAILAAGLSD-------WVDVGVICALLLL 182

  Fly   493 FISLGRWLEHIAKGKTSEALSKLLSLKAA---DALLVEISPDFDIISEKVISVDYVQRGDILKVI 554
            ..|:| :::....|...:.|.|.|:..|.   |..|:|| |..:::.           |:||::.
Yeast   183 NASVG-FIQEFQAGSIVDELKKTLANTATVIRDGQLIEI-PANEVVP-----------GEILQLE 234

  Fly   555 PGAKVPVDGKVLYGHSSC----DESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTT 615
            .|...|.||:::  ...|    |:|.|||||:...|..|..|...|..:.|...:..|.||:||.
Yeast   235 SGTIAPADGRIV--TEDCFLQIDQSAITGESLAAEKHYGDEVFSSSTVKTGEAFMVVTATGDNTF 297

  Fly   616 LAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHM 680
            :.:...||.:|...:....::   :.|..:..:|:|.:..|:.|....:....:|.:
Yeast   298 VGRAAALVGQASGVEGHFTEV---LNGIGIILLVLVIATLLLVWTACFYRTVGIVSI-------- 351

  Fly   681 DQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVF 745
                      .:..|.:..|..|..|.....|.:.|.....|....:|:..:|:|:...|:.:..
Yeast   352 ----------LRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCS 406

  Fly   746 DKTGTITHG-----TPMT----SKVTLFVTAQVCSLA----RALTIVGAAEQNSEHPIASAIVHF 797
            |||||:|..     .|.|    |...|.:||  |..|    :.|..:..|              |
Yeast   407 DKTGTLTKNKLSLHEPYTVEGVSPDDLMLTA--CLAASRKKKGLDAIDKA--------------F 455

  Fly   798 AKDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRII--------NYENLH 854
            .|.::.......|.:..|...|........:||      .:.::...:||:        ..:.:.
Yeast   456 LKSLIEYPKAKDALTKYKVLEFHPFDPVSKKVT------AVVESPEGERIVCVKGAPLFVLKTVE 514

  Fly   855 RTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIG 919
            ..||   :|.|...:.|:.:.:.:.|....|.
Yeast   515 EDHP---IPEDVHENYENKVAELASRGFRALG--------------------------------- 543

  Fly   920 NREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGI 984
                               :..:..:||..:|    |.:.||    |..:.:....:...:.:|:
Yeast   544 -------------------VARKRGEGHWEIL----GVMPCM----DPPRDDTAQTINEARNLGL 581

  Fly   985 DVVLLTGDNKNTAASIAREVGIRT-VY----------------------------AEVLPSHKVA 1020
            .:.:||||....|....|::|:.| :|                            |||.|.||..
Yeast   582 RIKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYR 646

  Fly  1021 KIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSR 1085
            .::.:|..|..|||.||||||:|:|.:||.||.:...||.|..|:|||.:...|..::..|..||
Yeast   647 VVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSR 711

  Fly  1086 CTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMA 1125
            ....|: |::....:...|.:.:..||          |:|
Yeast   712 QIFHRM-YSYVVYRIALSLHLEIFLGL----------WIA 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	162/755 (21%)
		HMA	287..350	CDD:238219
		E1-E2_ATPase	489..735	CDD:278548	57/252 (23%)
		COG4087	<984..1085	CDD:226572	41/129 (32%)
PMA2	NP_015289.1	P-type_ATPase_H	116..903	CDD:319771	162/755 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840