Protein Alignment ATP7 and PMA1

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_011507.1
• Gene: PMA1 / 852876
• SGDID: S000002976
• Length: 918
• Species: Saccharomyces cerevisiae
• Alignment Length: 739
• Identity: 175/739 - (23%)
• Similarity: 280/739 - (37%)
• Gaps: 176/739 - (23%)

  Fly   440 RAIKHGTTNM---------DVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFIS 495
            |..|:|...|         ..::..|..|.:|...|.::||.|    |..:.|.....:|::...
Yeast    96 RRKKYGLNQMADEKESLVVKFVMFFVGPIQFVMEAAAILAAGL----SDWVDFGVICGLLMLNAG 156

  Fly   496 LGRWLEHIAKGKTSEALSKLLSLKAA---DALLVEISPDFDIISEKVISVDYVQRGDILKVIPGA 557
            :| :::....|...:.|.|.|:..|.   |..|||| |..:::.           ||||::..|.
Yeast   157 VG-FVQEFQAGSIVDELKKTLANTAVVIRDGQLVEI-PANEVVP-----------GDILQLEDGT 208

  Fly   558 KVPVDGKVLYGHSSC----DESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQ 618
            .:|.||:::  ...|    |:|.|||||:.|.|..|......|..:.|...:..|.||:||.:.:
Yeast   209 VIPTDGRIV--TEDCFLQIDQSAITGESLAVDKHYGDQTFSSSTVKRGEGFMVVTATGDNTFVGR 271

  Fly   619 IVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQN 683
            ...||.:|...:....::   :.|..:..:|:|.:..|:.|....:....:|.:
Yeast   272 AAALVNKAAGGQGHFTEV---LNGIGIILLVLVIATLLLVWTACFYRTNGIVRI----------- 322

  Fly   684 TIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKT 748
                   .:..|.:..|..|..|.....|.:.|.....|....:|:..:|:|:...|:.:..|||
Yeast   323 -------LRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKT 380

  Fly   749 GTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSF 813
            ||:|...              .||....|:.|.                :.|.|.:.|...|...
Yeast   381 GTLTKNK--------------LSLHEPYTVEGV----------------SPDDLMLTACLAASRK 415

  Fly   814 GKSSHFQAVPGCGIRVTVSNYEQTLRQACNA-DRIINYENLHRTHPQGSVPVDNGASIEHLLPQR 877
            .|          |:......:.::|:|...| |.:..|:.| ..||...|.....|.:|....:|
Yeast   416 KK----------GLDAIDKAFLKSLKQYPKAKDALTKYKVL-EFHPFDPVSKKVTAVVESPEGER 469

  Fly   878 SV-RKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEV------PLEI 935
            .| .|...|        .||:..||   |..|   ||.:     .|..|....|:      .|.:
Yeast   470 IVCVKGAPL--------FVLKTVEE---DHPI---PEDV-----HENYENKVAELASRGFRALGV 515

  Fly   936 SDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASI 1000
            :    .:..:||..:|    |.:.||    |..:.:....|...:.:|:.|.:||||....|...
Yeast   516 A----RKRGEGHWEIL----GVMPCM----DPPRDDTAQTVSEARHLGLRVKMLTGDAVGIAKET 568

  Fly  1001 AREVGIRT-VY----------------------------AEVLPSHKVAKIQRIQANGIRVAMVG 1036
            .|::|:.| :|                            |||.|.||...::.:|..|..|||.|
Yeast   569 CRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTG 633

  Fly  1037 DGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMY 1101
            |||||:|:|.:||.||.:...||.|..|:|||.:...|..::..|..||....|: |::....:.
Yeast   634 DGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRM-YSYVVYRIA 697

  Fly  1102 NLLGIPLASGLFAPYGFTLLPWMA 1125
            ..|.:.:..||          |:|
Yeast   698 LSLHLEIFLGL----------WIA 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374
		HMA	287..350	CDD:238219
		P-type_ATPase_Cu-like	376..1130	CDD:319783	175/739 (24%)
PMA1	NP_011507.1	P-type_ATPase_H	87..874	CDD:319771	175/739 (24%)