Protein Alignment ATP7 and PCA1

DIOPT Version :9

• Sequence 1: NP_001259466.1
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_009854.2
• Gene: PCA1 / 852598
• SGDID: S000000499
• Length: 1216
• Species: Saccharomyces cerevisiae
• Alignment Length: 983
• Identity: 247/983 - (25%)
• Similarity: 433/983 - (44%)
• Gaps: 243/983 - (24%)

  Fly   254 ANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIES--------HVLK-- 308
            :.:|:.|.|...:.        ::....|...:.|.:.||:|..|.:|::.        |.||
Yeast   388 SRIVSMEPIENHLN--------LEAGSTGTEHIVLSVSGMSCTGCESKLKKSFGALKCVHGLKTS 444

  Fly   309 ------------IRGVTTASVTLLTKRGKFRY---------------------ITEETGPRSICE 340
                        .:|.....:..|:|..:|:|                     |.|| .|:.:.|
Yeast   445 LILSQAEFNLDLAQGSVKDVIKHLSKTTEFKYEQISNHGSTIDVVVPYAAKDFINEE-WPQGVTE 508

  Fly   341 A------IEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVA--MIYFMLEM 397
            .      |..:.|:.|::..||                    ||:..:..|..:|  ..:..:|:
Yeast   509 LKIVERNIIRIYFDPKVIGARD--------------------LVNEGWSVPVSIAPFSCHPTIEV 553

  Fly   398 SDKGHANMCC---LVPGLSMENLVM----------------FLLSTPVQFFGGFHFYVQSYRA-I 442
            ..|....:.|   |...|::..|||                .:|:|.:||.....||:.:.:: |
Yeast   554 GRKHLVRVGCTTALSIILTIPILVMAWAPQLREKISTISASMVLATIIQFVIAGPFYLNALKSLI 618

  Fly   443 KHGTTNMDVLISMVTTISYVYSVA-----VVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEH 502
            ......||:||.:.|:.:|::|:.     ||...:..||      ||:|..:|:..|.:||::..
Yeast   619 FSRLIEMDLLIVLSTSAAYIFSIVSFGYFVVGRPLSTEQ------FFETSSLLVTLIMVGRFVSE 677

  Fly   503 IAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLY 567
            :|:.:..:::| :.||:|:.|:||:.:.     .|..|::..:|.|||.||:|.:::|.||.|:.
Yeast   678 LARHRAVKSIS-VRSLQASSAILVDKTG-----KETEINIRLLQYGDIFKVLPDSRIPTDGTVIS 736

  Fly   568 GHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAP 632
            |.|..||:|||||||||.|:..|:|:.||:|..|.|.|:.:....|.|::.|..:|:||:.:|..
Yeast   737 GSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPK 801

  Fly   633 IQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSV 697
            ||.:||:||.||||.::.::.:|...||.:|        :.:|.:...|    .|..|...|::|
Yeast   802 IQNIADKIASYFVPTIIGITVVTFCVWIAVG--------IRVEKQSRSD----AVIQAIIYAITV 854

  Fly   698 LAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVT 762
            |.::|||.:|||.|...::|:|..|..||:.|.|.::|.||....||||||||:|.|     |:|
Yeast   855 LIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEG-----KLT 914

  Fly   763 LFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGI 827
            :...........:.:::....:..:||::.||..:.|:.   |.:.|     ..|:.:||  .|.
Yeast   915 VVHETVRGDRHNSQSLLLGLTEGIKHPVSMAIASYLKEK---GVSAQ-----NVSNTKAV--TGK 969

  Fly   828 RVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLS 892
            ||..::|.....|..|. |.:.:.|                       ...|||::|
Yeast   970 RVEGTSYSGLKLQGGNC-RWLGHNN-----------------------DPDVRKALE-------- 1002

  Fly   893 DLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQ 957
                                                                :|::....::||.
Yeast  1003 ----------------------------------------------------QGYSVFCFSVNGS 1015

  Fly   958 LVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRT--VYAEVLPSHKVA 1020
            :..::|:.|.::.:|...:..|::.||.:.:|:||:.....|:|..:||.:  :.:...|:.|..
Yeast  1016 VTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSE 1080

  Fly  1021 KIQRI----------QANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLL 1075
            .|:.|          |:....|...|||.||:..|.||.:|:.|..|::||..|:|:|:::..|.
Yeast  1081 YIKDIVEGRNCDSSSQSKRPVVVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLN 1145

  Fly  1076 DVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSS 1140
            :::..:.:|:..:.|::.||.::..|||..|.||:|.|.  .|.:.|..|.:....|.:.|:..:
Yeast  1146 NILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFV--DFHIPPEYAGLGELVSILPVIFVA 1208

  Fly  1141 LLLKMYRK 1148
            :||: |.|
Yeast  1209 ILLR-YAK 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219	3/19 (16%)
		ZntA	285..1131	CDD:225127	237/933 (25%)
		HMA	287..350	CDD:238219	21/111 (19%)
		E1-E2_ATPase	489..735	CDD:278548	89/245 (36%)
		COG4087	<984..1085	CDD:226572	31/112 (28%)
PCA1	NP_009854.2	HMA	413..471	CDD:238219	11/57 (19%)
		ATPase-IB1_Cu	605..1193	CDD:273664	196/712 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810