Protein Alignment ATP7 and PCA1

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_009854.2
• Gene: PCA1 / 852598
• SGDID: S000000499
• Length: 1216
• Species: Saccharomyces cerevisiae
• Alignment Length: 983
• Identity: 247/983 - (25%)
• Similarity: 433/983 - (44%)
• Gaps: 243/983 - (24%)

  Fly   254 ANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIES--------HVLK-- 308
            :.:|:.|.|...:.        ::....|...:.|.:.||:|..|.:|::.        |.||
Yeast   388 SRIVSMEPIENHLN--------LEAGSTGTEHIVLSVSGMSCTGCESKLKKSFGALKCVHGLKTS 444

  Fly   309 ------------IRGVTTASVTLLTKRGKFRY---------------------ITEETGPRSICE 340
                        .:|.....:..|:|..:|:|                     |.|| .|:.:.|
Yeast   445 LILSQAEFNLDLAQGSVKDVIKHLSKTTEFKYEQISNHGSTIDVVVPYAAKDFINEE-WPQGVTE 508

  Fly   341 A------IEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVA--MIYFMLEM 397
            .      |..:.|:.|::..||                    ||:..:..|..:|  ..:..:|:
Yeast   509 LKIVERNIIRIYFDPKVIGARD--------------------LVNEGWSVPVSIAPFSCHPTIEV 553

  Fly   398 SDKGHANMCC---LVPGLSMENLVM----------------FLLSTPVQFFGGFHFYVQSYRA-I 442
            ..|....:.|   |...|::..|||                .:|:|.:||.....||:.:.:: |
Yeast   554 GRKHLVRVGCTTALSIILTIPILVMAWAPQLREKISTISASMVLATIIQFVIAGPFYLNALKSLI 618

  Fly   443 KHGTTNMDVLISMVTTISYVYSVA-----VVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEH 502
            ......||:||.:.|:.:|::|:.     ||...:..||      ||:|..:|:..|.:||::..
Yeast   619 FSRLIEMDLLIVLSTSAAYIFSIVSFGYFVVGRPLSTEQ------FFETSSLLVTLIMVGRFVSE 677

  Fly   503 IAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLY 567
            :|:.:..:::| :.||:|:.|:||:.:.     .|..|::..:|.|||.||:|.:::|.||.|:.
Yeast   678 LARHRAVKSIS-VRSLQASSAILVDKTG-----KETEINIRLLQYGDIFKVLPDSRIPTDGTVIS 736

  Fly   568 GHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAP 632
            |.|..||:|||||||||.|:..|:|:.||:|..|.|.|:.:....|.|::.|..:|:||:.:|..
Yeast   737 GSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPK 801

  Fly   633 IQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSV 697
            ||.:||:||.||||.::.::.:|...||.:|        :.:|.:...|    .|..|...|::|
Yeast   802 IQNIADKIASYFVPTIIGITVVTFCVWIAVG--------IRVEKQSRSD----AVIQAIIYAITV 854

  Fly   698 LAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVT 762
            |.::|||.:|||.|...::|:|..|..||:.|.|.::|.||....||||||||:|.|     |:|
Yeast   855 LIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEG-----KLT 914

  Fly   763 LFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGI 827
            :...........:.:::....:..:||::.||..:.|:.   |.:.|     ..|:.:||  .|.
Yeast   915 VVHETVRGDRHNSQSLLLGLTEGIKHPVSMAIASYLKEK---GVSAQ-----NVSNTKAV--TGK 969

  Fly   828 RVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLS 892
            ||..::|.....|..|. |.:.:.|                       ...|||::|
Yeast   970 RVEGTSYSGLKLQGGNC-RWLGHNN-----------------------DPDVRKALE-------- 1002

  Fly   893 DLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQ 957
                                                                :|::....::||.
Yeast  1003 ----------------------------------------------------QGYSVFCFSVNGS 1015

  Fly   958 LVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRT--VYAEVLPSHKVA 1020
            :..::|:.|.::.:|...:..|::.||.:.:|:||:.....|:|..:||.:  :.:...|:.|..
Yeast  1016 VTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSE 1080

  Fly  1021 KIQRI----------QANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLL 1075
            .|:.|          |:....|...|||.||:..|.||.:|:.|..|::||..|:|:|:::..|.
Yeast  1081 YIKDIVEGRNCDSSSQSKRPVVVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLN 1145

  Fly  1076 DVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSS 1140
            :::..:.:|:..:.|::.||.::..|||..|.||:|.|.  .|.:.|..|.:....|.:.|:..:
Yeast  1146 NILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFV--DFHIPPEYAGLGELVSILPVIFVA 1208

  Fly  1141 LLLKMYRK 1148
            :||: |.|
Yeast  1209 ILLR-YAK 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374	3/21 (14%)
		HMA	287..350	CDD:238219	21/111 (19%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	213/792 (27%)
PCA1	NP_009854.2	HMA	413..471	CDD:238219	11/57 (19%)
		ATPase-IB1_Cu	605..1193	CDD:273664	196/712 (28%)