DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and HMA5

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_176533.1	Gene:	HMA5 / 842650	AraportID:	AT1G63440	Length:	995	Species:	Arabidopsis thaliana

Alignment Length:	1089	Identity:	395/1089 - (36%)
Similarity:	578/1089 - (53%)	Gaps:	202/1089 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQE 162
            :|:||||.:|..::|..|...||||...:......|::.:.|...|...|.|.|:|.|||||:.|
plant    56 QVLGMTCSACAGSVEKAIKRLPGIHDAVIDALNNRAQILFYPNSVDVETIRETIEDAGFEASLIE 120

  Fly   163 PRSPSQSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIE 227
            ..:..:|..                                     .|.:.|.||||.||.:.||
plant   121 NEANERSRQ-------------------------------------VCRIRINGMTCTSCSSTIE 148

  Fly   228 KHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGE--AEVELEI 290
            :..:.:.|:....|||...:||:.::..:.:.:.:.:.|...||...||   ..||  ::::|:|
plant   149 RVLQSVNGVQRAHVALAIEEAEIHYDPRLSSYDRLLEEIENAGFEAVLI---STGEDVSKIDLKI 210

  Fly   291 MGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGF------EA 349
            .|......:..||..:..:.||.:..::..|.:....|..:.||||:..:.||:..|      :|
plant   211 DGELTDESMKVIERSLEALPGVQSVEISHGTDKISVLYKPDVTGPRNFIQVIESTVFGHSGHIKA 275

  Fly   350 KLMT----GRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCLVP 410
            .:.:    ||:.      :.:.||:::..:||.||:|..|..:..:.||             .:|
plant   276 TIFSEGGVGRES------QKQGEIKQYYKSFLWSLVFTVPVFLTAMVFM-------------YIP 321

  Fly   411 GLSMENLVMF--------------LLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISY 461
            |:  ::|:||              :|:|||||..|:.||..||:|::.|:.||||||::.|..:|
plant   322 GI--KDLLMFKVINMLTVGEIIRCVLATPVQFVIGWRFYTGSYKALRRGSANMDVLIALGTNAAY 384

  Fly   462 VYSVAVVIAAVLLEQNSSP----LTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAAD 522
            .||:..|:.|.     :||    :.||:|..||:.||.||::||.:||||||:|::||::|....
plant   385 FYSLYTVLRAA-----TSPDFKGVDFFETSAMLISFIILGKYLEVMAKGKTSQAIAKLMNLAPDT 444

  Fly   523 ALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKR 587
            |:|:.:..:.::..|:.|....:|:.|::|::|||||..||.|::|.|..:||:||||:.|||||
plant   445 AILLSLDKEGNVTGEEEIDGRLIQKNDVIKIVPGAKVASDGYVIWGQSHVNESMITGEARPVAKR 509

  Fly   588 KGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVS 652
            ||..||||::|:||||.|:.|..|..:.|||||||||.||.:|||:|:|||||:.:|||.|:.:|
plant   510 KGDTVIGGTLNENGVLHVKVTRVGSESALAQIVRLVESAQLAKAPVQKLADRISKFFVPLVIFLS 574

  Fly   653 SITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVS------YAFKCALSVLAIACPCALGLATP 711
            ..|.:||.:.|             |:|....:.|.|      .|.:..:||:.||||||||||||
plant   575 FSTWLAWFLAG-------------KLHWYPESWIPSSMDSFELALQFGISVMVIACPCALGLATP 626

  Fly   712 TAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARAL 776
            |||||.||.||..|||:||..|||.||||..:|||||||:|.|.|:..|..|.   :...|....
plant   627 TAVMVGTGVGASQGVLIKGGQALERAHKVNCIVFDKTGTLTMGKPVVVKTKLL---KNMVLREFY 688

  Fly   777 TIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQA 841
            .:|.|.|.|||||:|.|||.:||...:....|   ::.::..|.::.|.|::.||...|
plant   689 ELVAATEVNSEHPLAKAIVEYAKKFRDDEENP---AWPEACDFVSITGKGVKATVKGRE------ 744

  Fly   842 CNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQ 906

plant   745 ----------------------------------------------------------------- 744

  Fly   907 KIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPE 971
                     :::||:..|..:.:.:|.:..:.:...|....|.:|.::|.:|:.:.:|||.:||.
plant   745 ---------IMVGNKNLMNDHKVIIPDDAEELLADSEDMAQTGILVSINSELIGVLSVSDPLKPS 800

  Fly   972 AHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVG 1036
            |..|:..||.|.|..:::||||..||.||||||||.:|.||..|..|..|::.:||.|..|||||
plant   801 AREAISILKSMNIKSIMVTGDNWGTANSIAREVGIDSVIAEAKPEQKAEKVKELQAAGHVVAMVG 865

  Fly  1037 DGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMY 1101
            ||:||||||..||||:.|.||||:|.||:|||||:::|.||:..:||||.|..|||.|:.:|..|
plant   866 DGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFSRIRLNYVWALGY 930

  Fly  1102 NLLGIPLASG-LFAPYGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKP 1149
            ||:|||:|:| ||....|.|.||:|..|||||||||||.|||||.|::|
plant   931 NLMGIPIAAGVLFPGTRFRLPPWIAGAAMAASSVSVVCCSLLLKNYKRP 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219	22/60 (37%)
		HMA	214..274	CDD:238219	18/59 (31%)
		ZntA	285..1131	CDD:225127	330/880 (38%)
		HMA	287..350	CDD:238219	16/68 (24%)
		E1-E2_ATPase	489..735	CDD:278548	123/251 (49%)
		COG4087	<984..1085	CDD:226572	59/100 (59%)
HMA5	NP_176533.1	HMA	54..117	CDD:238219	22/60 (37%)
		HMA	133..194	CDD:238219	18/60 (30%)
		HMA	<222..265	CDD:238219	12/42 (29%)
		P-type_ATPase_Cu-like	298..975	CDD:319783	322/795 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	182	1.000	Domainoid score	I1022
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35
Inparanoid	1	1.050	626	1.000	Inparanoid score	I200
OMA	1	1.010	-	-		QHG53773
OrthoDB	1	1.010	-	-		D649559at2759
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		otm3257
orthoMCL	1	0.900	-	-		OOG6_100289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1231
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.740