DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and HMA1

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_195444.1	Gene:	HMA1 / 829881	AraportID:	AT4G37270	Length:	819	Species:	Arabidopsis thaliana

Alignment Length:	891	Identity:	224/891 - (25%)
Similarity:	375/891 - (42%)	Gaps:	203/891 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LKIRGVTTASV----TLLTKRGKFRYITEETGPRSI-CEAIEALGFEAKLMTGRDKMAHNYLEH- 365
            |::..|.:.|:    |||.::......:....|||| ..|:|....:......:|...|::..|
plant    24 LRLARVNSFSILPPKTLLRQKPLRISASLNLPPRSIRLRAVEDHHHDHHHDDEQDHHNHHHHHHQ 88

  Fly   366 --------KEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCLVPGL---------- 412
                    |.|.:..:..|..:...|   .|.:..::.|     |.::||....:
plant    89 HGCCSVELKAESKPQKMLFGFAKAIG---WVRLANYLRE-----HLHLCCSAAAMFLAAAVCPYL 145

  Fly   413 -------SMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIA 470
                   |::|..| ::..|:.   |....:.:...|..|..|:.||:::.       :.|.|..
plant   146 APEPYIKSLQNAFM-IVGFPLV---GVSASLDALMDIAGGKVNIHVLMALA-------AFASVFM 199

  Fly   471 AVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIAKG-KTSEALSKLLSLKAAD---ALLVEIS-- 529
            ...||..           :||...:|.    |||:. .||.::..:..||.::   |||:|:.
plant   200 GNALEGG-----------LLLAMFNLA----HIAEEFFTSRSMVDVKELKESNPDSALLIEVHNG 249

  Fly   530 --PDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVV 592
              |:...:|.|.:.|..|:.|..:.|..|..||||.:|..|.::.....:|||..|:..:.|..|
plant   250 NVPNISDLSYKSVPVHSVEVGSYVLVGTGEIVPVDCEVYQGSATITIEHLTGEVKPLEAKAGDRV 314

  Fly   593 IGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLI 657
            .||:.|.:|.::|:||....::||.:||:|.|||.::|..:|:..|.....:...|||:|    :
plant   315 PGGARNLDGRMIVKATKAWNDSTLNKIVQLTEEAHSNKPKLQRWLDEFGENYSKVVVVLS----L 375

  Fly   658 AWIIIG---FSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATG 719
            |...:|   |..|.|...|....::.             ||.::..|.||||.:| |.|...|..
plant   376 AIAFLGPFLFKWPFLSTAACRGSVYR-------------ALGLMVAASPCALAVA-PLAYATAIS 426

  Fly   720 TGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKV------------TLFVTAQVCSL 772
            :.|..|:|:|||..|:......|:.||||||:|.| .:|.|.            :..:|..:.:.
plant   427 SCARKGILLKGAQVLDALASCHTIAFDKTGTLTTG-GLTCKAIEPIYGHQGGTNSSVITCCIPNC 490

  Fly   773 AR-ALTIVGAAEQNSEHPIASAIVHFA--KDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNY 834
            .: ||.:..|.|:.:.|||..|:|..:  ||:.::        |.:|  |:..||.|:..||
plant   491 EKEALAVAAAMEKGTTHPIGRAVVDHSVGKDLPSI--------FVES--FEYFPGRGLTATV--- 542

  Fly   835 EQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPE 899
                                           ||  ::.:..:..:||: .|.:.:.::.|....:
plant   543 -------------------------------NG--VKTVAEESRLRKA-SLGSIEFITSLFKSED 573

  Fly   900 EELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALN-GQLVCMFA 963
            |.                               .:|.|.: :....|...|..||: .|.|.:..
plant   574 ES-------------------------------KQIKDAV-NASSYGKDFVHAALSVDQKVTLIH 606

  Fly   964 VSDMVKPEAHLAVYTLKRMG-IDVVLLTGDNKNTAASIAREVGIRTVYAEVLPSHKVAKIQRI-- 1025
            :.|..:|.....:..||... :.|::||||:.::|..:|..|||..||..:.|..|:..::.|
plant   607 LEDQPRPGVSGVIAELKSWARLRVMMLTGDHDSSAWRVANAVGITEVYCNLKPEDKLNHVKNIAR 671

  Fly  1026 QANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEA-SDIVLMRNDLLDVVACLDLSRCTVR 1089
            :|.| .:.|||:|:||:||||.|.|||.:|......|.| :||:|:|:::..|..|:..||.|..
plant   672 EAGG-GLIMVGEGINDAPALAAATVGIVLAQRASATAIAVADILLLRDNITGVPFCVAKSRQTTS 735

  Fly  1090 RIRYN-------FFFASMYNLLG-IPLASGLFAPYGFTLLPWMASV 1127
            .::.|       .|.|::.::|| :||...:....|.|||..:.||
plant   736 LVKQNVALALTSIFLAALPSVLGFVPLWLTVLLHEGGTLLVCLNSV 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	224/891 (25%)
		HMA	287..350	CDD:238219	12/47 (26%)
		E1-E2_ATPase	489..735	CDD:278548	79/256 (31%)
		COG4087	<984..1085	CDD:226572	40/103 (39%)
HMA1	NP_195444.1	ATPase-IB2_Cd	185..785	CDD:273665	192/718 (27%)
		E1-E2_ATPase	207..442	CDD:278548	79/256 (31%)
		COG4087	<613..715	CDD:226572	39/102 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649559at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820