Protein Alignment ATP7 and HMA3

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_194741.2
• Gene: HMA3 / 829135
• AraportID: AT4G30120
• Length: 542
• Species: Arabidopsis thaliana
• Alignment Length: 577
• Identity: 146/577 - (25%)
• Similarity: 253/577 - (43%)
• Gaps: 107/577 - (18%)

  Fly   289 EIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMT 353
            :::|:.|:|.|:.:.:.:.::.||...||.:.::.....:.|....|..|.:|:.....||.:..
plant    18 DVVGICCSSEVSIVGNVLRQVDGVKEFSVIVPSRTVIVVHDTFLISPLQIVKALNQARLEASVRP 82

  Fly   354 -GRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCLVPGLSMENL 417
             |...:.          .:|.:.|  :::.|  .::.:.:|....|......:..:|.|
plant    83 YGETSLK----------SQWPSPF--AIVSG--VLLVLSFFKYFYSPLEWLAIVAVVAG------ 127

  Fly   418 VMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLT 482
            |..:|:..|.                 ..|...:.|:.:|.|:       |||.:.::.
plant   128 VFPILAKAVA-----------------SVTRFRLDINALTLIA-------VIATLCMQD------ 162

  Fly   483 FFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQR 547
            |.:...::.:| |:..|||..|..|.|..:|.|:||....|::.:...:.|        ||.|..
plant   163 FTEAATIVFLF-SVADWLESSAAHKASIVMSSLMSLAPRKAVIADTGLEVD--------VDEVGI 218

  Fly   548 GDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGE 612
            ..::.|..|..:|:||.|:.|....||..:||||.||:|::.|.|:..:||.||.:.|:.|....
plant   219 NTVVSVKAGESIPIDGVVVDGSCDVDEKTLTGESFPVSKQRESTVMAATINLNGYIKVKTTALAR 283

  Fly   613 NTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHK 677
            :..:|::.:||||||.|:...|:..|:.:.|:.|.|||.::...:            :||.::.:
plant   284 DCVVAKMTKLVEEAQKSQTKTQRFIDKCSRYYTPAVVVSAACFAV------------IPVLLKVQ 336

  Fly   678 MHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKT 742
                    .:|:.|..||.||...|||.|.|:||.|...|....|.:|.|:|....||...|:|.
plant   337 --------DLSHWFHLALVVLVSGCPCGLILSTPVATFCALTKAATSGFLIKTGDCLETLAKIKI 393

  Fly   743 VVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTI------VGAAEQNSEHPIASAIVHFAKDM 801
            |.||||||||...        |:.:...||:.::.:      |.:.|..|.||:|:|::.:|:
plant   394 VAFDKTGTITKAE--------FMVSDFRSLSPSINLHKLLYWVSSIECKSSHPMAAALIDYAR-- 448

  Fly   802 LNVGATPQAGSFGKSSHFQAVPGCGI-------RVTVSNYEQTLRQACNADRIINYE 851
             :|...|:....   .:||..||.|:       .:.:.|.....|..|..|.:.:.|
plant   449 -SVSVEPKPDIV---ENFQNFPGEGVYGRIDGQDIYIGNKRIAQRAGCLTDNVPDIE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374
		HMA	287..350	CDD:238219	13/60 (22%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	130/489 (27%)
HMA3	NP_194741.2	CopZ	13..74	CDD:442020	12/55 (22%)
		Haloacid Dehalogenase-like Hydrolases	96..>542	CDD:473868	130/489 (27%)