DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and HMA2

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001320088.1	Gene:	HMA2 / 829134	AraportID:	AT4G30110	Length:	951	Species:	Arabidopsis thaliana

Alignment Length:	964	Identity:	244/964 - (25%)
Similarity:	392/964 - (40%)	Gaps:	267/964 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 EIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKL-M 352
            :::|:.|.|.|..||:.:..:.||...||.:.::.....:.|.......|.:|:.....||.: :
plant    12 DVLGICCTSEVPLIENILNSMDGVKEFSVIVPSRTVIVVHDTLILSQFQIVKALNQAQLEANVRV 76

  Fly   353 TGRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCLVPGLSMENL 417
            ||.....:          ||.:.|.|                              |.|
plant    77 TGETNFKN----------KWPSPFAV------------------------------VSG------ 95

  Fly   418 VMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYS------VAVVIAAV--LL 474
            ::.|||    ||                              .|:||      ||.|:|.:  :|
plant    96 ILLLLS----FF------------------------------KYLYSPFRWLAVAAVVAGIYPIL 126

  Fly   475 EQNSSPLTFFDTPPMLLIFISLG---------------------RWLEHIAKGKTSEALSKLLSL 518
            .:..:.|..|.....:|:.:::|                     .||:..|..|.|..:..|:||
plant   127 AKAVASLARFRIDINILVVVTVGATIGMQDYTEAAVVVFLFTIAEWLQSRASYKASAVMQSLMSL 191

  Fly   519 KAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMP 583
            ....|::.|...:        :.||.::...::.|..|..:|:||.|:.|:...||..:|||:.|
plant   192 APQKAVIAETGEE--------VEVDELKTNTVIAVKAGETIPIDGVVVDGNCEVDEKTLTGEAFP 248

  Fly   584 VAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFV 648
            |.|.|.|.|..|:||.||.:.|..|...|:..:|::.:||||||.||...|:..|:.:.|:.|.:
plant   249 VPKLKDSTVWAGTINLNGYITVNTTALAEDCVVAKMAKLVEEAQNSKTETQRFIDKCSKYYTPAI 313

  Fly   649 VVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTA 713
            :::|    |.::.|.|:   |....::|.:|:             ||.||..||||.|.|:||.|
plant   314 ILIS----ICFVAIPFA---LKVHNLKHWVHL-------------ALVVLVSACPCGLILSTPVA 358

  Fly   714 VMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTI 778
            ...|....|.:|:|:|||..||...|:|.|.||||||||.|.        |:.....||:..:::
plant   359 TFCALTKAATSGLLIKGADYLETLAKIKIVAFDKTGTITRGE--------FIVMDFQSLSEDISL 415

  Fly   779 ------VGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQT 837
                  |.:.|..|.||:|:|:|.:|:. ::|...|:|     ...:|..||.||      |.:
plant   416 QSLLYWVSSTESKSSHPMAAAVVDYARS-VSVEPKPEA-----VEDYQNFPGEGI------YGK- 467

  Fly   838 LRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEEL 902

plant   468 ----------------------------------------------------------------- 467

  Fly   903 LTDQKIIDSPEILVLIGNREWMER-NAIEVP-LEISDCMTHEERKGHTAVLCALNGQLVCMFAVS 965
                  ||..|  |.|||:....| ..:.|| :::      :.:.|.|.....:...|..:|.:|
plant   468 ------IDGKE--VYIGNKRIASRAGCLSVPDIDV------DTKGGKTIGYVYVGETLAGVFNLS 518

  Fly   966 DMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVG--IRTVYAEVLPSHKVAKIQRIQAN 1028
            |..:.....|:..||.:||.:.:|||||...|.....::|  :..|.||:||..|...|::::..
plant   519 DACRSGVAQAMKELKSLGIKIAMLTGDNHAAAMHAQEQLGNAMDIVRAELLPEDKSEIIKQLKRE 583

  Fly  1029 GIRVAMVGDGVNDSPALAQADVGITI-AAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIR 1092
            ....||||||:||:||||.||:||:: .:|:.:|.|..:|:||.||:..:...:.|::...|::.
plant   584 EGPTAMVGDGLNDAPALATADIGISMGVSGSALATETGNIILMSNDIRRIPQAIKLAKRAKRKVV 648

  Fly  1093 YNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSSLLL---------KMYRK 1148
            .|...:  ..:.|..||.. ||  |..|: |.|.:|...:.:.|:.:|:||         |.||:
plant   649 ENVVIS--ITMKGAILALA-FA--GHPLI-WAAVLADVGTCLLVILNSMLLLSDKHKTGNKCYRE 707

  Fly  1149 PTAKTLRTAE-YEAQLAAERASGSEDELDKLSLHRGL--DDLPEKGRMPFKRSS 1199
            .::.::..|| .|...|.:..:|...::.......|.  ....||...|.|.||
plant   708 SSSSSVLIAEKLEGDAAGDMEAGLLPKISDKHCKPGCCGTKTQEKAMKPAKASS 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	225/882 (26%)
		HMA	287..350	CDD:238219	14/60 (23%)
		E1-E2_ATPase	489..735	CDD:278548	80/266 (30%)
		COG4087	<984..1085	CDD:226572	40/103 (39%)
HMA2	NP_001320088.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649559at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820