Protein Alignment ATP7 and atp7a

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001036185.1
• Gene: atp7a / 564924
• ZFINID: ZDB-GENE-060825-45
• Length: 1482
• Species: Danio rerio
• Alignment Length: 1255
• Identity: 585/1255 - (46%)
• Similarity: 793/1255 - (63%)
• Gaps: 113/1255 - (9%)

  Fly     3 SDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIA 67
            |:...::|::|: ..:.||.|.|||.||.::|.:...:..|.|.||.......::|:|.....:.
Zfish   267 SEPPADSTVTTL-FQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSVVELQ 330

  Fly    68 SDIDDM---GFECSYPGDAADPPE----TPASAWTNIRVVGMTCQSCVRNIEGNIGTKPGIHSIE 125
            ..|:.:   .|:...|..    ||    .|..:...|.:.||||.|||::|||.:..|.|:.|.:
Zfish   331 KAIEALPPGNFKAIIPAS----PEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQ 391

  Fly   126 VQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRS--PS--QSPSPAPASSPKKRATPTP 186
            |.||......:|||....|.::...|:||||:|.:.|..|  ||  :||||:..||     :.:|
Zfish   392 VSLANHQGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSPSVRSS-----SLSP 451

  Fly   187 PPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVK 251
            ...:..:|.:..........::|||:.|.|||||||||.||::.|..||:.|:||||:|:||||:
Zfish   452 VRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVR 516

  Fly   252 FNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTAS 316
            ::.:|:....||:.|.||||...::|..|..:..:||.:.||||||||:||||:::|.:|:..||
Zfish   517 YSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYAS 581

  Fly   317 VTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLVSLI 381
            |.|.|.:...:|..|.||||.|...||.:||.|.|:. :|:.. ::|:|..|||:|:.:|.:||.
Zfish   582 VALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVK-KDRPG-SHLDHSREIRQWKRSFQISLF 644

  Fly   382 FGGPCMVAMIYFML--EMSDKGHANMCC-----------------LVPGLSMENLVMFLLSTPVQ 427
            |..|.|..|||.::  .|.||.|.:...                 |:||||:.||:.||...|||
Zfish   645 FCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQ 709

  Fly   428 FFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLI 492
            |.||.:||.|:|:|:||.|.||||||.:.|||::.|||.|::.|::.....:|:|||||||||.:
Zfish   710 FIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFV 774

  Fly   493 FISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGA 557
            |||||||||.|||.|||||||||:||:|.:|.:|.::.|..::||:.:.|:.|||||::||:||.
Zfish   775 FISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGG 839

  Fly   558 KVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRL 622
            |.||||:|:.|||..||||||||:|||.|:.||.||.|||||||.||::|||.|.:|||:|||:|
Zfish   840 KFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKL 904

  Fly   623 VEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKMHMDQNTII 686
            |||||||||||||.||:|:.|||||:||:|.:||:|||||||.|.:||..... :...:.:...:
Zfish   905 VEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAV 969

  Fly   687 VSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTI 751
            :.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||:::|||||||||
Zfish   970 IRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTI 1034

  Fly   752 THGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKS 816
            |:|.|...:|.:.........::.|.|||.||.:||||:.:||..:.|..|.      ..|.|..
Zfish  1035 TYGAPKVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELG------TESLGTC 1093

  Fly   817 SHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLH----------RTHPQGSVPVDNGASIE 871
            :.||||||||||..|||.|..|::. ::|   :.||.|          |.|           |.|
Zfish  1094 TDFQAVPGCGIRCLVSNTENLLKRE-DSD---SEENQHNAVLIQISDARAH-----------STE 1143

  Fly   872 HLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEIS 936
            |                    .|:::|:.  ||   ::.:....|||||||||.|||::|..::.
Zfish  1144 H--------------------PLIMDPQP--LT---VVQTASYTVLIGNREWMRRNALQVRADVD 1183

  Fly   937 DCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIA 1001
            :.||..||:|.||||.|::.:|..|.|::|.|||||.|||:.|..||::|||:||||..||.:||
Zfish  1184 EAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIA 1248

  Fly  1002 REVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASD 1066
            .:||||.|:|||||||||||::::|..|.||||||||||||||||.|||||.|..|||||.||:|
Zfish  1249 AQVGIRKVFAEVLPSHKVAKVEQLQQAGKRVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAAD 1313

  Fly  1067 IVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAA 1131
            :||:||||||||..:|||:.||:|||.||.||.||||:|||:|:|:|.|.|..|.|||.|.|||.
Zfish  1314 VVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMAL 1378

  Fly  1132 SSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMPFK 1196
            ||||||.||||||.|.|||.:.|:     .:|...|..||   |..:|:|.|:.:|    |.|..
Zfish  1379 SSVSVVLSSLLLKCYTKPTVEKLK-----RRLGDVRTHGS---LSDVSVHIGMGEL----RRPSP 1431

  Fly  1197 RSSTSLISRIFMHDYGNITS 1216
            :  .||:.|...:...:|.|
Zfish  1432 K--LSLLDRFVNYSRASINS 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020	17/67 (25%)
		HMA	97..159	CDD:238219	26/61 (43%)
		chaper_CopZ_Eh	212..276	CDD:411374	33/63 (52%)
		HMA	287..350	CDD:238219	32/62 (52%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	408/783 (52%)
atp7a	NP_001036185.1	CopZ	9..72	CDD:442020
		CopZ	173..240	CDD:442020
		HMA	279..336	CDD:238219	16/56 (29%)
		CopZ	361..424	CDD:442020	26/62 (42%)
		HMA	477..539	CDD:238219	33/61 (54%)
		HMA	552..615	CDD:238219	32/62 (52%)
		P-type_ATPase_Cu-like	637..1377	CDD:319783	408/785 (52%)