DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP7 and atp7a

DIOPT Version :9

Sequence 1:NP_001259466.1 Gene:ATP7 / 32142 FlyBaseID:FBgn0030343 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_001036185.1 Gene:atp7a / 564924 ZFINID:ZDB-GENE-060825-45 Length:1482 Species:Danio rerio


Alignment Length:1255 Identity:585/1255 - (46%)
Similarity:793/1255 - (63%) Gaps:113/1255 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIA 67
            |:...::|::|: ..:.||.|.|||.||.::|.:...:..|.|.||.......::|:|.....:.
Zfish   267 SEPPADSTVTTL-FQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSVVELQ 330

  Fly    68 SDIDDM---GFECSYPGDAADPPE----TPASAWTNIRVVGMTCQSCVRNIEGNIGTKPGIHSIE 125
            ..|:.:   .|:...|..    ||    .|..:...|.:.||||.|||::|||.:..|.|:.|.:
Zfish   331 KAIEALPPGNFKAIIPAS----PEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQ 391

  Fly   126 VQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRS--PS--QSPSPAPASSPKKRATPTP 186
            |.||......:|||....|.::...|:||||:|.:.|..|  ||  :||||:..||     :.:|
Zfish   392 VSLANHQGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSPSVRSS-----SLSP 451

  Fly   187 PPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVK 251
            ...:..:|.:..........::|||:.|.|||||||||.||::.|..||:.|:||||:|:||||:
Zfish   452 VRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVR 516

  Fly   252 FNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTAS 316
            ::.:|:....||:.|.||||...::|..|..:..:||.:.||||||||:||||:::|.:|:..||
Zfish   517 YSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYAS 581

  Fly   317 VTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLVSLI 381
            |.|.|.:...:|..|.||||.|...||.:||.|.|:. :|:.. ::|:|..|||:|:.:|.:||.
Zfish   582 VALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVK-KDRPG-SHLDHSREIRQWKRSFQISLF 644

  Fly   382 FGGPCMVAMIYFML--EMSDKGHANMCC-----------------LVPGLSMENLVMFLLSTPVQ 427
            |..|.|..|||.::  .|.||.|.:...                 |:||||:.||:.||...|||
Zfish   645 FCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQ 709

  Fly   428 FFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLI 492
            |.||.:||.|:|:|:||.|.||||||.:.|||::.|||.|::.|::.....:|:|||||||||.:
Zfish   710 FIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFV 774

  Fly   493 FISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGA 557
            |||||||||.|||.|||||||||:||:|.:|.:|.::.|..::||:.:.|:.|||||::||:||.
Zfish   775 FISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGG 839

  Fly   558 KVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRL 622
            |.||||:|:.|||..||||||||:|||.|:.||.||.|||||||.||::|||.|.:|||:|||:|
Zfish   840 KFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKL 904

  Fly   623 VEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKMHMDQNTII 686
            |||||||||||||.||:|:.|||||:||:|.:||:|||||||.|.:||..... :...:.:...:
Zfish   905 VEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAV 969

  Fly   687 VSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTI 751
            :.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||:::|||||||||
Zfish   970 IRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTI 1034

  Fly   752 THGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKS 816
            |:|.|...:|.:.........::.|.|||.||.:||||:.:||..:.|..|.      ..|.|..
Zfish  1035 TYGAPKVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELG------TESLGTC 1093

  Fly   817 SHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLH----------RTHPQGSVPVDNGASIE 871
            :.||||||||||..|||.|..|::. ::|   :.||.|          |.|           |.|
Zfish  1094 TDFQAVPGCGIRCLVSNTENLLKRE-DSD---SEENQHNAVLIQISDARAH-----------STE 1143

  Fly   872 HLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEIS 936
            |                    .|:::|:.  ||   ::.:....|||||||||.|||::|..::.
Zfish  1144 H--------------------PLIMDPQP--LT---VVQTASYTVLIGNREWMRRNALQVRADVD 1183

  Fly   937 DCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIA 1001
            :.||..||:|.||||.|::.:|..|.|::|.|||||.|||:.|..||::|||:||||..||.:||
Zfish  1184 EAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIA 1248

  Fly  1002 REVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASD 1066
            .:||||.|:|||||||||||::::|..|.||||||||||||||||.|||||.|..|||||.||:|
Zfish  1249 AQVGIRKVFAEVLPSHKVAKVEQLQQAGKRVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAAD 1313

  Fly  1067 IVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAA 1131
            :||:||||||||..:|||:.||:|||.||.||.||||:|||:|:|:|.|.|..|.|||.|.|||.
Zfish  1314 VVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMAL 1378

  Fly  1132 SSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMPFK 1196
            ||||||.||||||.|.|||.:.|:     .:|...|..||   |..:|:|.|:.:|    |.|..
Zfish  1379 SSVSVVLSSLLLKCYTKPTVEKLK-----RRLGDVRTHGS---LSDVSVHIGMGEL----RRPSP 1431

  Fly  1197 RSSTSLISRIFMHDYGNITS 1216
            :  .||:.|...:...:|.|
Zfish  1432 K--LSLLDRFVNYSRASINS 1449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP7NP_001259466.1 HMA 16..78 CDD:238219 17/64 (27%)
HMA 97..159 CDD:238219 26/61 (43%)
HMA 214..274 CDD:238219 33/59 (56%)
ZntA 285..1131 CDD:225127 450/875 (51%)
HMA 287..350 CDD:238219 32/62 (52%)
E1-E2_ATPase 489..735 CDD:278548 151/246 (61%)
COG4087 <984..1085 CDD:226572 71/100 (71%)
atp7aNP_001036185.1 HMA 11..74 CDD:238219
HMA 174..237 CDD:238219
HMA 279..336 CDD:238219 16/56 (29%)
HMA 362..424 CDD:238219 26/61 (43%)
HMA 477..539 CDD:238219 33/61 (54%)
ZntA 550..1377 CDD:225127 449/874 (51%)
HMA 552..615 CDD:238219 32/62 (52%)
E1-E2_ATPase 771..1018 CDD:278548 151/246 (61%)
HAD_like 1171..1324 CDD:304363 96/152 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 237 1.000 Domainoid score I2255
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H35
Inparanoid 1 1.050 1017 1.000 Inparanoid score I276
OMA 1 1.010 - - QHG53773
OrthoDB 1 1.010 - - D33208at33208
OrthoFinder 1 1.000 - - FOG0001874
OrthoInspector 1 1.000 - - otm26123
orthoMCL 1 0.900 - - OOG6_100289
Panther 1 1.100 - - O PTHR43520
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R123
SonicParanoid 1 1.000 - - X1231
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1414.010

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