Protein Alignment ATP7 and atp7b

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_684415.5
• Gene: atp7b / 556499
• ZFINID: ZDB-GENE-061220-5
• Length: 1364
• Species: Danio rerio
• Alignment Length: 1334
• Identity: 587/1334 - (44%)
• Similarity: 792/1334 - (59%)
• Gaps: 171/1334 - (12%)

  Fly     1 MPSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPAR 65
            :||:|      ..|::.:.|||||||||:|.|.||:..|::||:|.|.:......::|.:..|..
Zfish    94 LPSEE------GMVKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVSLSDKEAILRFNPAKVTPED 152

  Fly    66 IASDIDDMGFEC----------------------------------------------------- 77
            :...|:||||:.
Zfish   153 MRKRIEDMGFDALILALQGQIQPLSTDWSEVTLGVEGMHCGSCVKNITETLSGMLGVNSVFVSLE 217

  Fly    78 --------------------------------SYPG--DAADPPETPASAWTNIRVVGMTCQSCV 108
                                            |.||  ...:...||..:.| |.:.||||.|||
Zfish   218 KGSVDLRFDPSLLTLETVKGFLEEIPPGNFRVSIPGWSSRLNSASTPTQSVT-IGIEGMTCNSCV 281

  Fly   109 RNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEA------SVQEPRSPS 167
            :.|||.:..:.|:.||:|.|..|...|.:|.....|.::...|:||||||      .:.|..|.|
Zfish   282 QAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWLNQDSEICEVSSVS 346

  Fly   168 QSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKK 232
            |.||.......::..:...|.|...:|.....   |:| |.|||:|:.||||||||:.||::..|
Zfish   347 QMPSGLKHLPSQRHPSKPSPSPITKENADGTG---ERE-LRKCFVHVTGMTCASCVSNIERNLVK 407

  Fly   233 IYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCAS 297
            ..|:.|:||||:|.|||||::..::....|.:.|:.|||...:::|....:..::|.:.||||||
Zfish   408 HEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVMEEHSVQDGVLDLSVTGMTCAS 472

  Fly   298 CVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNY 362
            ||:.|||.:|:.:|:..|||.|.|.:...::.::..|.|.|...||.|||...|:  :::..:|.
Zfish   473 CVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLI--KNEGLNNT 535

  Fly   363 LEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFM-LEMSDKGHANMC----CLVPGLSMENLVMFLL 422
            |:|:||||:|:::||.||:||.|.|..|||.| ::...|.|....    .::||||:.||..|||
Zfish   536 LDHQEEIRQWKHSFLFSLVFGIPVMGLMIYMMVMDSQHKEHGGSMPADQNILPGLSIINLAFFLL 600

  Fly   423 STPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTP 487
            .|||||.||.:||:|:||:::||..||||||.:.|||:||||..|:|.|::.....|||||||||
Zfish   601 CTPVQFLGGRYFYIQAYRSLRHGVANMDVLIVLATTIAYVYSFTVLIVAMIEGAKQSPLTFFDTP 665

  Fly   488 PMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILK 552
            |||.:||:|||||||:||.||||||:||:||:|.||.:|.:.||..||.|:.:|||.|||||::|
Zfish   666 PMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATDATIVSLGPDNTIIREEQVSVDLVQRGDVVK 730

  Fly   553 VIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLA 617
            |.||.|.||||||:.|.|..||||||||.|||.|:.||.||.||||.:|.|||||||.|..|||:
Zfish   731 VAPGGKFPVDGKVIEGTSMADESLITGEPMPVIKKAGSCVIAGSINAHGALLVEATHVGSETTLS 795

  Fly   618 QIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKMHMD 681
            |||:|||||||||||||||||:::||||||:||:|.:|:.||:||||.:.::|..... :..::.
Zfish   796 QIVKLVEEAQTSKAPIQQLADKLSGYFVPFIVVISILTVTAWLIIGFLDFDVVSKNFPGYNQNIS 860

  Fly   682 QNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFD 746
            :..:||.:||:.:::||:|||||:|||||||||||.||.||.||:|:||...||.||||..|:||
Zfish   861 RTEVIVRFAFQASITVLSIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVGAVMFD 925

  Fly   747 KTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAG 811
            ||||||:|.|..::|.:........|...|.:||.||.:||||:..|:....|:.|.      |.
Zfish   926 KTGTITNGVPQVTRVLVLWDRARLPLRTVLAVVGTAEASSEHPLGMAVAKHCKEELG------AE 984

  Fly   812 SFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQ 876
            :.|....|||||||||...||:.|..|:.:                                 |:
Zfish   985 TLGFCHDFQAVPGCGISCKVSSVEDLLQNS---------------------------------PK 1016

  Fly   877 RSVRKSMELNNQQLLSDL--VLEPEEELLTD-QKIIDSPEILVLIGNREWMERNAIEVPLEISDC 938
            ....|:..:....||..|  |...|..|:.| ....|||...||||||:||.||.:||..::.:.
Zfish  1017 TQETKASAVKQTPLLVTLQGVTTDESSLVADTDSGSDSPSYSVLIGNRQWMLRNGLEVTADVDNA 1081

  Fly   939 MTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIARE 1003
            |:..|.||.||:|.|::|.|..|.||:|.||.|:.|||:||..|||:|.::||||:.||.:||.:
Zfish  1082 MSSHETKGQTAILVAIDGVLCAMIAVADTVKAESALAVHTLSSMGIEVYMITGDNRRTARAIATQ 1146

  Fly  1004 VGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIV 1068
            ||||.|:|||||||||||:|.:|..|::|||||||||||||||.||:||.|..|||||.||:|||
Zfish  1147 VGIRKVFAEVLPSHKVAKVQELQERGLKVAMVGDGVNDSPALAHADLGIAIGTGTDVAIEAADIV 1211

  Fly  1069 LMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASS 1133
            |:|||||||||.::||:.||:|||.||.||.:|||||||.|:|:|.|.|..|.|||.|.||||||
Zfish  1212 LIRNDLLDVVASIELSKKTVQRIRINFVFALIYNLLGIPFAAGVFMPLGLVLQPWMGSAAMAASS 1276

  Fly  1134 VSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDD---LPEKGRMPF 1195
            ||||.|||||::::|.:.:     |||::..:.:.|.|..:   :|.|.||:.   .|...|...
Zfish  1277 VSVVLSSLLLRLFKKTSVE-----EYESRAQSHKLSLSPSQ---VSTHVGLESRRCSPLSDRKRR 1333

  Fly  1196 KRS---STSLISRIFMHDYGNITSPDAKYGEGLL 1226
            .||   |:|.||..|   :.:.|.|....|..::
Zfish  1334 SRSASGSSSFISGSF---HPSTTQPYNTSGRSIV 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020	25/64 (39%)
		HMA	97..159	CDD:238219	27/67 (40%)
		chaper_CopZ_Eh	212..276	CDD:411374	29/63 (46%)
		HMA	287..350	CDD:238219	27/62 (44%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	408/762 (54%)
atp7b	XP_684415.5	CopZ	100..164	CDD:442020	26/63 (41%)
		CopZ	182..242	CDD:442020	0/59 (0%)
		HMA	269..331	CDD:238219	26/62 (42%)
		HMA	389..449	CDD:238219	28/59 (47%)
		HMA	462..525	CDD:238219	27/62 (44%)
		P-type_ATPase_Cu-like	547..1267	CDD:319783	404/758 (53%)