DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATP7 and ATP7B

DIOPT Version :9

Sequence 1:NP_001259466.1 Gene:ATP7 / 32142 FlyBaseID:FBgn0030343 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_000044.2 Gene:ATP7B / 540 HGNCID:870 Length:1465 Species:Homo sapiens


Alignment Length:1234 Identity:577/1234 - (46%)
Similarity:771/1234 - (62%) Gaps:143/1234 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 TVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDM---G 74
            |::|.|.||.|:|||.||.|:|||..|:..::|.||.......|||..|.|..:...|:.:   .
Human   258 TLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGN 322

  Fly    75 FECSYP----GDAAD-----------PPETPAS---AWTNIRVVGMTCQSCVRNIEGNIGTKPGI 121
            |:.|.|    |...|           ||.....   :.|.|.:.||||.|||.:|||.|....|:
Human   323 FKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGV 387

  Fly   122 HSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSP----APASSPKKRA 182
            ..|.|.||...|.|.|:|:...|.::...|:||||||||.   |.|.|.:|    :..:|..:..
Human   388 QQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVV---SESCSTNPLGNHSAGNSMVQTT 449

  Fly   183 TPTPP------------PPSYA--------QNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIE 227
            ..||.            |.::|        |:..||| |      .||||.|:||||||||:.||
Human   450 DGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVA-P------QKCFLQIKGMTCASCVSNIE 507

  Fly   228 KHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMG 292
            ::.:|..|:.|:||||:|.|||:|::..|:....||:.|.:|||...::::....:..:||.|.|
Human   508 RNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITG 572

  Fly   293 MTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDK 357
            |||||||:.|||.:.:..|:|.|||.|.|.:...::..|..|||.|.:.||.:||.|.| ..|:.
Human   573 MTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASL-AQRNP 636

  Fly   358 MAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCC---LVPGLSMENLVM 419
            .|| :|:||.||::|:.:||.||:||.|.|..||| ||..|::.|.:|..   ::||||:.||:.
Human   637 NAH-HLDHKMEIKQWKKSFLCSLVFGIPVMALMIY-MLIPSNEPHQSMVLDHNIIPGLSILNLIF 699

  Fly   420 FLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFF 484
            |:|.|.||..||::||||:|::::|.:.||||||.:.|:|:||||:.:::.||..:...||:|||
Human   700 FILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFF 764

  Fly   485 DTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGD 549
            ||||||.:||:|||||||:||.||||||:||:||:|.:|.:|.:..|..||.|:.:.::.|||||
Human   765 DTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGD 829

  Fly   550 ILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENT 614
            |:||:||.|.|||||||.|::..||||||||:|||.|:.||.||.||||.:|.:|::|||.|.:|
Human   830 IVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDT 894

  Fly   615 TLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIG----------FSNPNL 669
            ||||||:||||||.|||||||||||.:||||||::::|::||:.||:||          |.||| 
Human   895 TLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPN- 958

  Fly   670 VPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATAL 734
                    .|:.|..:|:.:||:.:::||.|||||:|||||||||||.||..|.||:|:||...|
Human   959 --------KHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPL 1015

  Fly   735 ENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAK 799
            |.|||:|||:||||||||||.|...:|.|........|.:.|.:||.||.:||||:..|:..:.|
Human  1016 EMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK 1080

  Fly   800 DMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPV 864
            :.|.      ..:.|..:.|||||||||...|||.|..|   .:::|.::....| .:..||:|.
Human  1081 EELG------TETLGYCTDFQAVPGCGIGCKVSNVEGIL---AHSERPLSAPASH-LNEAGSLPA 1135

  Fly   865 DNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAI 929
            :..|     :||                                    ...||||||||:.||.:
Human  1136 EKDA-----VPQ------------------------------------TFSVLIGNREWLRRNGL 1159

  Fly   930 EVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNK 994
            .:..::||.||..|.||.||:|.|::|.|..|.|::|.||.||.|||:||:.||:||||:||||:
Human  1160 TISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR 1224

  Fly   995 NTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTD 1059
            .||.:||.:|||..|:|||||||||||:|.:|..|.:||||||||||||||||||:|:.|..|||
Human  1225 KTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD 1289

  Fly  1060 VAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWM 1124
            ||.||:|:||:|||||||||.:.||:.||||||.|...|.:|||:|||:|:|:|.|.|..|.|||
Human  1290 VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWM 1354

  Fly  1125 ASVAMAASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDEL--DKLSLHRGLDD 1186
            .|.||||||||||.|||.||.|:||..:     .||||     |.|....|  .::|:|.|:||
Human  1355 GSAAMAASSVSVVLSSLQLKCYKKPDLE-----RYEAQ-----AHGHMKPLTASQVSVHIGMDD 1408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP7NP_001259466.1 HMA 16..78 CDD:238219 25/64 (39%)
HMA 97..159 CDD:238219 28/61 (46%)
HMA 214..274 CDD:238219 30/59 (51%)
ZntA 285..1131 CDD:225127 437/858 (51%)
HMA 287..350 CDD:238219 30/62 (48%)
E1-E2_ATPase 489..735 CDD:278548 147/255 (58%)
COG4087 <984..1085 CDD:226572 70/100 (70%)
ATP7BNP_000044.2 E1-E2_ATPase 769..1016 CDD:278548 147/255 (58%)
COG4087 <1206..1309 CDD:226572 72/102 (71%)
HMA 61..124 CDD:238219
HMA 146..209 CDD:238219
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..249
HMA 260..318 CDD:238219 24/57 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..355 7/32 (22%)
HMA 363..425 CDD:238219 28/61 (46%)
HMA 492..554 CDD:238219 31/61 (51%)
ZntA 566..1355 CDD:225127 433/851 (51%)
HMA 567..630 CDD:238219 30/62 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145876
Domainoid 1 1.000 236 1.000 Domainoid score I2347
eggNOG 1 0.900 - - E1_COG2217
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1029 1.000 Inparanoid score I273
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53773
OrthoDB 1 1.010 - - D33208at33208
OrthoFinder 1 1.000 - - FOG0001874
OrthoInspector 1 1.000 - - otm41927
orthoMCL 1 0.900 - - OOG6_100289
Panther 1 1.100 - - LDO PTHR43520
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R123
SonicParanoid 1 1.000 - - X1231
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

Return to query results.
Submit another query.