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Protein Alignment ATP7 and ATP7A

DIOPT Version :10

Sequence 1:	NP_572756.3	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens

Alignment Length:	1289	Identity:	592/1289 - (45%)
Similarity:	798/1289 - (61%)	Gaps:	114/1289 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 STVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMG-- 74
            ||....|.||.|:|||.||...:.....:..:.|.||..:....|:.....|..:...|:.:.
Human   277 STATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPG 341

  Fly    75 -FECSYPGDAADPPETPASA----------------WTNIRVVGMTCQSCVRNIEGNIGTKPGIH 122
             :..|...:......:|:|:                .|.|.:.||||.|||::|||.|..|||:.
Human   342 LYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVK 406

  Fly   123 SIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSP----SQSPSPAPASSPKKRAT 183
            ||.|.||..|..|:|||....|..:...|:||||:|::.:...|    :|..|..|..
Human   407 SIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLL------- 464

  Fly   184 PTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKA 248
             |.....|.:..:.|....|.:..:||::.:.|||||||||.||::.::..|:.||||||:|.||
Human   465 -TSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKA 528

  Fly   249 EVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVT 313
            ||::|..|:....||:.|.||||...:|:..|.|:..:||.:.||||||||:||||.:.|.||:.
Human   529 EVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGIL 593

  Fly   314 TASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLV 378
            ..||.|.|.:...:|..|..|||.|...||:|||||.|:. :|:.| ::|:||.|||:||.:|||
Human   594 YCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVK-KDRSA-SHLDHKREIRQWRRSFLV 656

  Fly   379 SLIFGGPCMVAMIYFML------------EMSDKG----HANMCC---LVPGLSMENLVMFLLST 424
            ||.|..|.|..|||.|:            .||.:.    |::|..   ::||||:.||:.|||..
Human   657 SLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCV 721

  Fly   425 PVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPM 489
            |||||||::||:|:|:|:||.|.||||||.:.|||::.||:.:::.|:......:|:||||||||
Human   722 PVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPM 786

  Fly   490 LLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVI 554
            |.:||:|||||||||||||||||:||:||:|.:|.:|.:..|..::||:.:.|:.||||||:||:
Human   787 LFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVV 851

  Fly   555 PGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQI 619
            ||.|.||||:|:.|||..||||||||:|||||:.||.||.|||||||.||:.|||.|.:|||:||
Human   852 PGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQI 916

  Fly   620 VRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKMHMDQN 683
            |:||||||||||||||.||:::||||||:|.||..||:.||:|||.|..:|..... :...:.:.
Human   917 VKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRT 981

  Fly   684 TIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKT 748
            ..|:.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||||.||||||
Human   982 ETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKT 1046

  Fly   749 GTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSF 813
            ||||||||:.::|.:...:...|..:.|.|||.||.|||||:.:||..:.|..|:      ..:.
Human  1047 GTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELD------TETL 1105

  Fly   814 GKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRS 878
            |....||.||||||...|:|.|..|.:        |..|:...:.:.:..|...||.|    |.|
Human  1106 GTCIDFQVVPGCGISCKVTNIEGLLHK--------NNWNIEDNNIKNASLVQIDASNE----QSS 1158

  Fly   879 VRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEE 943
            ...||.::.|  :|:              .:::.:..|||||||||.||.:.:..:::|.||..|
Human  1159 TSSSMIIDAQ--ISN--------------ALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHE 1207

  Fly   944 RKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRT 1008
            |||.||||.|::.:|..:.|::|.|||||.||::.||.||::|||:||||..||.|||.:|||..
Human  1208 RKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK 1272

  Fly  1009 VYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRND 1073
            |:|||||||||||::::|..|.||||||||:|||||||.|:|||.|..|||||.||:|:||:|||
Human  1273 VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRND 1337

  Fly  1074 LLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVC 1138
            ||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.||||||||||.
Human  1338 LLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVL 1402

  Fly  1139 SSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDL----PEKGRMPFKRSS 1199
            |||.||:|||||        ||:.....|:...:....::|:|.|:||.    |:.|
Human  1403 SSLFLKLYRKPT--------YESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLG-------- 1451

  Fly  1200 TSLISRIFMHDYGNITS--PDAKYGEGLLDPEEQYDGRTKIVRSRFHANDSTEL 1251
              |:.||..:...:|.|  .|.:....::..|..   :..::...|..:|.|.|
Human  1452 --LLDRIVNYSRASINSLLSDKRSLNSVVTSEPD---KHSLLVGDFREDDDTAL 1500

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.