Protein Alignment ATP7 and SERCA

DIOPT Version :9

• Sequence 1: NP_001259466.1
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Alignment Length: 857
• Identity: 197/857 - (22%)
• Similarity: 335/857 - (39%)
• Gaps: 246/857 - (28%)

  Fly   450 DVLISMVTTISYVYSVAVVIAAV--LLEQNSSPLTFFDTP-PMLLIFIS---LGRWLEHIAKGKT 508
            |:|:.::.       :|.:|:.|  |.|::....|.|..| .:|||.|:   :|.|.|..|:
  Fly    59 DLLVKILL-------LAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAE--- 113

  Fly   509 SEALSKLLSLKAADALLVEISPDFDIISEKVISVDY--VQR--------GDILKVIPGAKVPVDG 563
                |.:.:||       |..|:..    ||:..|.  :|:        ||:::|..|.|:|.|.
  Fly   114 ----SAIEALK-------EYEPEMG----KVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADI 163

  Fly   564 KVLYGHSS---CDESLITGESMPVAKRKGSVVIGGSINQN-----------------GVLLVEAT 608
            ::.:.:|:   .|:|::||||:.|.|...::....::||:                 ||::
  Fly   164 RITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVI---- 224

  Fly   609 HTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWII-IG-FSNPNLVP 671
            .||.:|.:.:|...:.|.:..|.|:||..|........   |:|.|.:..|.| || |::|
  Fly   225 GTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSK---VISVICVAVWAINIGHFNDP---- 282

  Fly   672 VAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALEN 736
               .|.....:..|   |.||.|:::...|.|..|.....|.:.:.|...|....:|:...::|.
  Fly   283 ---AHGGSWIKGAI---YYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVET 341

  Fly   737 AHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDM 801
            ......:..|||||:|......|::.:|               ...|.|.     |:.:.|  :|
  Fly   342 LGCTSVICSDKTGTLTTNQMSVSRMFIF---------------DKVEGND-----SSFLEF--EM 384

  Fly   802 LNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQ------ACNADRIINYENLHRTHPQG 860
            ......|....|..          |.|:..::|: ||::      .|| |..|:|....:...:.
  Fly   385 TGSTYEPIGEVFLN----------GQRIKAADYD-TLQELSTICIMCN-DSAIDYNEFKQAFEKV 437

  Fly   861 SVPVDNGASI-EHLLPQRSVRKS-MELNNQQLLSDLVLEPE------EELLTDQKIIDS------ 911
            ....:....: ...|...||.|| ::..:..:.....:|.:      .|...|:|.:.|
  Fly   438 GEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLK 502

  Fly   912 -------PEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAV---------LCALNGQ--- 957
                   |::.|         :.|.|..||  .| || .|.|.|.|         :.||.||
  Fly   503 ASRLGTGPKLFV---------KGAPEGVLE--RC-TH-ARVGTTKVPLTSALKAKILALTGQYGT 554

  Fly   958 ----LVCM-FAVSDM-VKP--------------EAHL------------------AVYTLKRMGI 984
                |.|: .||:|. :||              |.:|                  ::...:..||
  Fly   555 GRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGI 619

  Fly   985 DVVLLTGDNKNTAASIAREVGI-------------------------------RTVYAEVLPSHK 1018
            .|:::|||||.||.:|.|.:|:                               ..:::.|.|.||
  Fly   620 RVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHK 684

  Fly  1019 VAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDL 1083
            ...::.:|:.....||.||||||:|||.:|::||.:.:||.||..|:::||..::...:|:.::.
  Fly   685 SKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEE 749

  Fly  1084 SRCTVRR----IRYNFFFASMYNLLGIPLASGLFAPYGFTLLP----WMASVAMAASSVSVVCSS 1140
            .|.....    ||| ...:::..::.|.|.:.|..|.  .|:|    |:..|.....:.::..:.
  Fly   750 GRAIYNNMKQFIRY-LISSNIGEVVSIFLTAALGLPE--ALIPVQLLWVNLVTDGLPATALGFNP 811

  Fly  1141 LLLKMYRKPTAK 1152
            ..|.:..||..|
  Fly   812 PDLDIMEKPPRK 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	193/834 (23%)
		HMA	287..350	CDD:238219
		E1-E2_ATPase	489..735	CDD:278548	69/280 (25%)
		COG4087	<984..1085	CDD:226572	39/131 (30%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	197/857 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840