DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and PMCA

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	211/948 - (22%)
Similarity:	347/948 - (36%)	Gaps:	278/948 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 ISVDYVQRGDILKVIPGAKVPVDGKVLYGHS-SCDESLITGESMPVAK--------RKGSVVIGG 595
            |||..:..|||.:|..|..:|.||.::..:. ..|||.:||||..|.|        ..|:.|:.|
  Fly   181 ISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEG 245

  Fly   596 S---------IN-QNGVLLV------------------EATH-------TGEN------------ 613
            |         :| |.|::..                  ||..       ||||
  Fly   246 SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAP 310

  Fly   614 ----TTLAQIVRLVEE------------AQTS--------KAPIQQLADRIAGYFVPFVVVVSSI 654
                |..::|.:...|            |:|.        :|.:.:||.:| ||....:.|::.|
  Fly   311 SQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQI-GYAGSTIAVLTVI 374

  Fly   655 TLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATG 719
            .||....|.....:..|....:..::.::.||       .::||.:|.|..|.||...::..:..
  Fly   375 ILIIQFCIKTFVIDEKPWKNTYANNLVKHLII-------GVTVLVVAVPEGLPLAVTLSLAYSVK 432

  Fly   720 TGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVC-SLARALTIVGAAE 783
            ....:..||:...|.|.......:..|||||:|     |:::|: |.:.:| .|.:.|..:....
  Fly   433 KMMKDNNLVRHLDACETMGNATAICSDKTGTLT-----TNRMTV-VQSYICEKLCKVLPTLSDIP 491

  Fly   784 QNSEHPIASAI---VHFAKDML---NVGATP-QAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQA 841
            |:..:.|...|   ..:..:::   |.|..| |.|:..:.:....|.|.|::.      |::|..
  Fly   492 QHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKY------QSIRDE 550

  Fly   842 CNAD---RIINYENLHRT------HPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLE 897
            ...|   |:..:.::.::      .|.|...:....:.|.::.:.:.....|...::...|:
  Fly   551 ITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDM--- 612

  Fly   898 PEEELLTDQKIIDSPEI----LVLIGNREWMERNAI--EVPLEISDCMTHEERKGHTAVLCALNG 956
             :|.|:  :::|:....    .:.:..|:::...|.  ||.:: .:....:|....|.:.|
  Fly   613 -QERLI--REVIEPMACDGLRTISVAYRDFVPGKAAINEVHID-GEPNWDDEENIMTNLTC---- 669

  Fly   957 QLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGI--------------- 1006
              :|:..:.|.|:||...|:...:|.||.|.::||||.|||.|||.:.||
  Fly   670 --LCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEF 732

  Fly  1007 ----------------------RTVYAEVLPSHKVAKIQ-----RIQANGIRVAMVGDGVNDSPA 1044
                                  ..|.|...|:.|...::     .:..|...||:.|||.||.||
  Fly   733 NRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPA 797

  Fly  1045 LAQADVGITIA-AGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPL 1108
            |.:||||..:. ||||||.|||||:|..::...:|..:...|.....|.....|....|::.:.:
  Fly   798 LKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIV 862

  Fly  1109 A-SGLFA----PYGFTLLPW----MASVAMAASSVSVVCSSLLLKMYRKPTAKT----------- 1153
            | .|..|    |.....:.|    |.::|..|.:.......|||   |||..:|
  Fly   863 AFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL---RKPYGRTKPLISRTMMKN 924

  Fly  1154 -LRTAEY------------EAQLAAERASGSE----------------------DELDKLSLH-- 1181
             |..|.|            :..|..|...|.|                      :|::...:|
  Fly   925 ILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQ 989

  Fly  1182 ----RGLDDLP-----------------EKGRMPFKRSSTSLISRIFMHDYG--------NITS- 1216
                .||...|                 :.|:|.|...:.:|...::...:|        .|||
  Fly   990 RNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSV 1054

  Fly  1217 PDAK------YGEGLLDPEEQYDGRTKIVRSRFHANDS 1248
            |..|      :|.|  .|||..|| ..:...||.:.||
  Fly  1055 PTRKLPKILSWGRG--HPEEYTDG-MNLGEERFDSIDS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	170/745 (23%)
		HMA	287..350	CDD:238219
		E1-E2_ATPase	489..735	CDD:278548	62/274 (23%)
		COG4087	<984..1085	CDD:226572	46/143 (32%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	199/911 (22%)
		Cation_ATPase_N	36..104	CDD:279080
		E1-E2_ATPase	172..448	CDD:278548	62/274 (23%)
		Cation_ATPase	505..598	CDD:289987	15/98 (15%)
		HAD_like	676..807	CDD:119389	40/130 (31%)
		Cation_ATPase_C	873..1051	CDD:279079	29/180 (16%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840