Protein Alignment ATP7 and CG6230

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Alignment Length: 1125
• Identity: 204/1125 - (18%)
• Similarity: 358/1125 - (31%)
• Gaps: 413/1125 - (36%)

  Fly   206 LLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELG 270
            :|...||||  :|...|..::.            ::|.|..:......|||     :||.:
  Fly   111 VLAIAFLHI--LTLLFCYWSVH------------VLAFLTCRRVKLPGANV-----LAKVV---- 152

  Fly   271 FPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGP 335
             ||     |:||.:::               :.....|:...:|....:..|.   :|:..|  .
  Fly   153 -PT-----PNNGNSKI---------------VPIRSSKLEDGSTQYYFVFQKT---KYVWNE--D 191

  Fly   336 RSICEAIE--ALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMS 398
            |....|:|  ..|..:...:.|.      ||.:|:|::....:
  Fly   192 RKTFRAVEFPVNGLLSTYSSSRG------LETEEDIKRATQTY---------------------- 228

  Fly   399 DKGHANMCCLVPGLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVY 463
              |:..|..:||    |...:|:......||        .::....|...||..        :.|
  Fly   229 --GNNEMEMVVP----EFHELFIERATAPFF--------VFQVFSVGLWCMDDY--------WYY 271

  Fly   464 SVAVVIAAVLLE--------QNSSPLTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKA 520
            |:..:...:..|        :|.|.:......|.|:......:| .|:...
  Fly   272 SLFTLFMLIAFECTIVKQQLRNMSEIRKMGNKPYLIYAFRQNKW-RHLGSD-------------- 321

  Fly   521 ADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVA 585
                        :::...::|:...|..:|        ||.|..:|.|....|||::||||:|:.
  Fly   322 ------------ELLPGDLVSITRSQNDNI--------VPCDLVILRGSCIVDESMLTGESVPLM 366

  Fly   586 KR------------------KGSVVIGGS-INQ------------NGVLLVEATHTGENTTLAQI 619
            |.                  |..|:.||: :.|            :|..:.....||.||:..::
  Fly   367 KESLESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKL 431

  Fly   620 VR--LVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQ 682
            :|  |....:.::..::..|      |:.|::|. ::...:::.:..|..   |....:|:.::.
  Fly   432 LRTILFGANRATENNVETFA------FIAFLMVF-AVAAASYVWVKGSED---PERNRYKLFLEC 486

  Fly   683 NTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDK 747
            ..|:.        |::....|..|.||..|:::..|..    .|.......:..|.||:...|||
  Fly   487 TLILT--------SIIPPDLPIELTLAVNTSLIQLTKL----FVFCTEPFRIPFAGKVQICCFDK 539

  Fly   748 TGTITHGTPMTSKVTLFV--------------TAQVCSLARALTIV--GAAEQNSEHPIASAIVH 796
            |||:|....|...:....              |.||.:...:|.::  |......|....:|:..
  Fly   540 TGTLTTDNLMVEGIAGLAPNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDW 604

  Fly   797 FAKDMLNVGATPQAGSFG-----KSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRT 856
            ....|.:|  .|:...|.     :..||.:.              ..|.:..|..:|.|.|
  Fly   605 TLTKMDSV--IPKRPQFKPLKIIQRYHFSSA--------------LKRMSVLAGHLIPYSN---- 649

  Fly   857 HPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNR 921
                        .::|:   .:|:.:.|: .|::|.::..:.|:..|
  Fly   650 ------------EVKHI---GAVKGAPEV-IQKMLREVPADYEKVYL------------------ 680

  Fly   922 EWMERNAIEVPLEISDC----------MTHEERKGHTAVLCALN--GQLVCMFAVSDMVKPEAHL 974
            |:..|.|..:.|.|.|.          |..||      |.|.|.  |.|:    :|..:||::..
  Fly   681 EYARRGARVLALGIKDLGTLGAQRVREMKREE------VECDLTFAGFLI----ISCPMKPDSKS 735

  Fly   975 AVYTLKRMGIDVVLLTGDNKNTAASIAREV----------------------------------- 1004
            .:..|.:....||::|||:..||..:|||:
  Fly   736 VIKELIQSSHKVVMITGDSPLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSYELD 800

  Fly  1005 ----------------------GIR-----------------TVYAEVLPSHKVAKIQRIQANGI 1030
                                  |::                 ||.|...|..|...|.:::..|.
  Fly   801 TKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGY 865

  Fly  1031 RVAMVGDGVNDSPALAQADVGITI----------------AAGTDVAAEASDIVLMRNDLLDVVA 1079
            ...|.|||.||..||..|:||:::                .|..:.||.|:......|..|..
  Fly   866 CTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTT-- 928

  Fly  1080 CLDLSRCTVRRIRY-NFFFASMYNLLG-------IPLA-SGLFAPYGFTLLPWMASVAMAASSVS 1135
               ..|...||..: |...|.:.|.|.       :.|. :.:.||:             .:.|.|
  Fly   929 ---RERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPF-------------TSKSSS 977

  Fly  1136 VVCSSLLLKMYRKPTAKTLR 1155
            ::|.:.::|..|.....||:
  Fly   978 IMCVNHIIKQGRCTLVTTLQ 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374	14/63 (22%)
		HMA	287..350	CDD:238219	9/64 (14%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	164/926 (18%)
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	172/961 (18%)