Protein Alignment ATP7 and anne

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1095
• Identity: 211/1095 - (19%)
• Similarity: 364/1095 - (33%)
• Gaps: 372/1095 - (33%)

  Fly   294 TCASC-VNKIES--------------HVLKIRGVTTASV-TLLTKRGKFRYITEETGPRSICEAI 342
            ||:.| :.:.|.              ||.:|:.:|:::: |||.|.   :...|.|  ...|:.:
  Fly   203 TCSQCSLEEAEQVLVTEDYQGKHKMYHVKQIQVLTSSNLKTLLEKE---QQSIERT--HIECDHV 262

  Fly   343 E-ALGFEAKLMTGRDKMAHN--YLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHAN 404
            | .|.......:.:.|...:  ....|:.:..|.|                           :.|
  Fly   263 ENVLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNN---------------------------NTN 300

  Fly   405 MCCLVPGLSMENLVMFLLSTPVQFF---GGFHFYVQSYRAIKHGTTNMDV--------LISMVTT 458
            ....:.||.        |:.|..::   .|...:.|..|.|..|...:.|        |...|..
  Fly   301 RFQRINGLD--------LNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLN 357

  Fly   459 ISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADA 523
            ..||:.:..||.....:       ::....::|:....|..:..:...|..:.|.|.: ....:|
  Fly   358 PFYVFQLFSVILWFTYD-------YYYYACVILLMSVFGITVSVLQTKKNQDVLQKTV-YNTGNA 414

  Fly   524 LLVEISPDFDIISEKVISVDYVQR----GDILKVIP--GAKVPVDGKVLYGHSSCDESLITGESM 582
            .:|:         .|.:|.:...|    |||:: ||  |..:..|..::.|:...|||::||||:
  Fly   415 WVVD---------HKGLSKELPTRAIVPGDIIE-IPSSGCTLHCDAILISGNCILDESMLTGESV 469

  Fly   583 PVAKRK---------------------GSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEA 626
            ||.|..                     |:.||......:..:|....:||..|...:::|.:
  Fly   470 PVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSI--- 531

  Fly   627 QTSKAPIQQLADRIAGYFVPFVVVVSSI----TLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIV 687
             ....|:....::.:..|:.|:.:::.:    ||:..|:.| ::|  |.:|:|   .:|..||:|
  Fly   532 -LYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRG-TDP--VKIAVE---SLDLITIVV 589

  Fly   688 SYAFKCALSV-----------LAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVK 741
            ..|...|::|           ..|.|      .:|.::.||   |:||
  Fly   590 PPALPAAMTVGRFYAQKRLKTSEIFC------ISPRSINVA---GSIN----------------- 628

  Fly   742 TVVFDKTGTITH-GTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASA----IVHFAKDM 801
            ...||||||:|. |..|...|....|.|.                 :.|:.|.    ..||...|
  Fly   629 CCCFDKTGTLTEDGLDMWGVVPKSSTNQF-----------------QIPLKSVDRLPFDHFLFGM 676

  Fly   802 LNVGATPQAGSFGKSSHFQAVPGCGIRVTVSN------------YEQT---LRQACNADRIINYE 851
            :...:                      :|:.|            :|.|   |..:.|......|.
  Fly   677 VTCHS----------------------ITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYG 719

  Fly   852 NLHRT---HPQGSV----PVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEE-------- 901
            .|:.|   .|:|.:    ..::|:..| :..|.||        ..||:.:.:.|.::
  Fly   720 ILYPTILRQPRGGLSGMAETESGSKNE-IKRQSSV--------DDLLATVGISPSQKNFDHGIVR 775

  Fly   902 ----------------LLTDQKI----IDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKG 946
                            .|:||..    ..|||:|..:...:       .:|...|..::...:||
  Fly   776 EFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQ-------SLPDNYSQQLSEFAKKG 833

  Fly   947 HTAVLCAL----------------------NGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLL 989
            :..:..|.                      |.:.:....:.:.:||:....:..|....|..:::
  Fly   834 YRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMI 898

  Fly   990 TGDNKNTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITI 1054
            ||||..||.|:||:.||      |.||..|            :.:..|.:.||       ..|..
  Fly   899 TGDNILTAISVARDCGI------VSPSQSV------------ITVHADPIGDS-------ANIQT 938

  Fly  1055 AAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAP---- 1115
            ..||:...:.|.     :....:...|||...|.|.    :.|.|.:|       |.||.|
  Fly   939 NTGTECNFDNSS-----DKHYKLHYTLDLGSKTSRA----YLFKSCFN-------SNLFDPETPE 987

  Fly  1116 ----YGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAKTLRT-AEYEAQLAAERASGSEDE- 1174
                .|.|:....::.::...|.|....|.|.......:.||:.| ...:|:|..:.   :.||
  Fly   988 FTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKH---TPDES 1049

  Fly  1175 ---------LDKLSLHRGLDDLPEKGRMPFKRSSTSLISRIFMHDYGNITSPDAK 1220
                     :|..:.....|..||:..:...|.  |:.:|:         |||.|
  Fly  1050 WRRQECIFAMDGKTWQIVKDYFPEEMEILLTRG--SIYARM---------SPDQK 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374
		HMA	287..350	CDD:238219	17/72 (24%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	168/891 (19%)
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	19/97 (20%)
		P-type_ATPase_cation	326..1281	CDD:319842	184/932 (20%)