DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and ccc2

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_595829.1	Gene:	ccc2 / 2540525	PomBaseID:	SPBC29A3.01	Length:	904	Species:	Schizosaccharomyces pombe

Alignment Length:	978	Identity:	332/978 - (33%)
Similarity:	504/978 - (51%)	Gaps:	150/978 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELI 276
            |.::||||.||||:|:...:.:.|::...::||..:|....:.::::.:.||:.|.:.||...:|
pombe     6 LSVQGMTCTSCVASIQSMLEGVEGIEQFTISLLLERAIAVHDPSIISPDQIAEKIEDCGFDASVI 70

  Fly   277 DEPDNGEAEVELE--IMGMTCASCVNKIESHVLKIRGVTT--------ASVTLLTKRGKFRYITE 331
            ...: ||..|...  ::....|....|:.:|:.:::||.:        |::.::       |.:|
pombe    71 SSTE-GEHGVMANYLLLSPMQAEQWTKVHNHINELQGVLSVNCSSSPDAAIRVI-------YDSE 127

  Fly   332 ETGPRSICEAIEALGFEAKLM-----TGRDKMAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMI 391
            .||||||.:.|.::|.:....     |.|...    |:...:||.|:..|::|:.|.     ..:
pombe   128 ITGPRSIMKEILSMGVKCTFQPVDSSTSRILS----LQRGSQIRVWKIRFIISISFS-----LAV 183

  Fly   392 YFMLEMSDK-GHANMCCLVP---GLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVL 452
            .|:.::.|. .......|||   |:...:::..:||.||||..|..:|..:|.|:|.||.|||||
pombe   184 MFLPQIFDSCDSMRAAFLVPHYFGICAGHIISLVLSLPVQFGVGRVYYSAAYHALKRGTANMDVL 248

  Fly   453 ISMVTTISYVYSV-AVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLL 516
            :|:.:|:::..|: .:::.:.....|.:|: ||||..|||.|::|||:||..|||.||.|||:||
pombe   249 VSLGSTVAFAASIFFMILYSARHADNPAPI-FFDTADMLLTFVTLGRYLESKAKGSTSAALSQLL 312

  Fly   517 SLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGES 581
            ||..:.|.::|.:...:|::      |.::|||::.|.||..:||||.|:.|.|..|||.::||.
pombe   313 SLAPSSATIIEDNEQIEILA------DLIERGDLILVKPGEIIPVDGTVVEGSSYVDESSVSGEP 371

  Fly   582 MPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVP 646
            :||.|.....::.|:.|.||.|||:||.:...:.||.||.||:.||.|.|||||.|||:||.|||
pombe   372 VPVHKTIDDELLSGTANGNGRLLVKATKSPRESQLAVIVDLVQRAQISHAPIQQFADRVAGIFVP 436

  Fly   647 FVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATP 711
            .:|.:|..|...|.:       ....:.::....|......:...|..:||:.:||||||||:||
pombe   437 VIVALSISTFTFWFL-------FTKYSSKYPSVFDDPMGKFAVCLKLTISVVVVACPCALGLSTP 494

  Fly   712 TAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARAL 776
            |||||.||.||:||:::||...||..::|.|||||||||:|.|....:.:::     |.:|...|
pombe   495 TAVMVGTGVGALNGIIIKGGEILERLNQVDTVVFDKTGTLTVGKLSVTDISI-----VDNLEELL 554

  Fly   777 TI--------VGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSN 833
            .|        |.|:|.:|||||..||...|.:..:|      ...|..| |.||||.|:.|.:..
pombe   555 DIPKNIFWAFVKASESSSEHPIGKAITEKASEFTDV------SEIGIES-FNAVPGEGVDVVLRW 612

  Fly   834 YEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEP 898
            .|:|..
pombe   613 KERTFH----------------------------------------------------------- 618

  Fly   899 EEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQLVCMFA 963
                             .|:||...:|.|.:.:|.:....:......|.|.|..|::||.|....
pombe   619 -----------------ALLGNSLLLEHNNVSIPDDFDSKLKLSSSSGLTCVRIAIDGQFVGFLG 666

  Fly   964 VSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAR--EVGIRTVYAEVLPSHKVAKIQRIQ 1026
            ..|.|:|:::..|..||::|..|.|||||.|.||..:|:  |:....||||.:||.|...||:::
pombe   667 CMDQVRPDSYQTVSALKQLGKKVCLLTGDQKATARRVAQGLEIDFSDVYAEAVPSQKAEIIQKLK 731

  Fly  1027 ANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRND-LLDVVACLDLSRCTVRR 1090
            .....|||||||:||||:|..|||||....|:.:|.|::|::|:|.. |||.....||||..|:|
pombe   732 DQKHCVAMVGDGINDSPSLVLADVGIAPINGSGIALESADVILVRKGVLLDTAVSFDLSRVIVKR 796

  Fly  1091 IRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAKTLR 1155
            |:.|..:|.:||.:.||:|.|.|.|:|..|.|..||.||..||:||:.|||||:.::||.:....
pombe   797 IKMNLVWACIYNFVMIPIAMGFFLPWGIYLNPMWASAAMMFSSLSVLASSLLLRRWKKPKSLIFS 861

  Fly  1156 TAE 1158
            .|:
pombe   862 EAD 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219	18/59 (31%)
		ZntA	285..1131	CDD:225127	298/876 (34%)
		HMA	287..350	CDD:238219	16/72 (22%)
		E1-E2_ATPase	489..735	CDD:278548	108/245 (44%)
		COG4087	<984..1085	CDD:226572	48/103 (47%)
ccc2	NP_595829.1	ZntA	1..837	CDD:225127	320/949 (34%)
		HMA	5..68	CDD:238219	19/61 (31%)
		E1-E2_ATPase	285..518	CDD:278548	108/245 (44%)
		COG4087	670..791	CDD:226572	54/120 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	145	1.000	Domainoid score	I1143
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35
Inparanoid	1	1.050	377	1.000	Inparanoid score	I426
OMA	1	1.010	-	-		QHG53773
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		oto101823
orthoMCL	1	0.900	-	-		OOG6_100289
Panther	1	1.100	-	-	LDO	PTHR43520
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R123
SonicParanoid	1	1.000	-	-		X1231
TreeFam	1	0.960	-	-
	14	13.860