back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and Atp7a

DIOPT Version :10

Sequence 1:	NP_572756.3	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_434690.1	Gene:	Atp7a / 24941	RGDID:	2179	Length:	1492	Species:	Rattus norvegicus

Alignment Length:	1296	Identity:	577/1296 - (44%)
Similarity:	791/1296 - (61%)	Gaps:	123/1296 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARI 66
            |||       |.:...|.||.|:|||.||...:.....:..:.|.||..:....|:.....|..:
  Rat   274 PSD-------SAITFTIDGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEIL 331

  Fly    67 ASDIDDMG---FECSYPGDAADPPETPASAWTN----------------IRVVGMTCQSCVRNIE 112
            ...|:.:.   :..|...:...|..:|:|:...                |.:.||||.|||::||
  Rat   332 RKAIEAVSPGQYRVSISSEVESPTSSPSSSSLQKMPLNLVSQPLTQEVVININGMTCNSCVQSIE 396

  Fly   113 GNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASS 177
            |.|..|||:.||.|.|......::|||....|..:.|.|:||||:|.:     |:....|....:
  Rat   397 GVISKKPGVKSIHVSLTNSTGTIEYDPLLTSPEPLREAIEDMGFDAVL-----PADMKEPLVVIA 456

  Fly   178 PKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVA 242
            .....||..|..:..:|   |..||:    .||::.:.|||||||||.||::.::..|:.|:|||
  Rat   457 QPSLETPLLPSTTEPEN---VMTPVQ----NKCYIQVSGMTCASCVANIERNLRREEGIYSVLVA 514

  Fly   243 LLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVL 307
            |:|.||||::|..|:....||:.|.||||...:::....|...:||.:.||||||||:||||.:.
  Rat   515 LMAGKAEVRYNPAVIQPRVIAELIRELGFGAVVMENAGEGNGILELVVRGMTCASCVHKIESTLT 579

  Fly   308 KIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKW 372
            |.:|:...||.|.|.:...:|..|..|||.|...|..|||||.|:. :|:.| |:|:||.||::|
  Rat   580 KHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGNLGFEASLVK-KDRSA-NHLDHKREIKQW 642

  Fly   373 RNAFLVSLIFGGPCMVAMIYFML------------EMSDKGHANMCC-------LVPGLSMENLV 418
            |.:|||||.|..|.|..|||.|:            .||::...||..       ::||||:.||:
  Rat   643 RGSFLVSLFFCIPVMGLMIYMMVMDHHLATLNHNQNMSNEEMINMHSSMFLERQILPGLSIMNLL 707

  Fly   419 MFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTF 483
            ..||..||||.||::||:|:|:|::|.|.||||||.:.|||::.||:.:::.|:......:|:||
  Rat   708 SLLLCLPVQFCGGWYFYIQAYKALRHKTANMDVLIVLATTIAFAYSLVILLVAMYERAKVNPITF 772

  Fly   484 FDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRG 548
            |||||||.:||:|||||||||||||||||:||:||:|.:|.:|.::.:..::||:.:.|:.||||
  Rat   773 FDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRG 837

  Fly   549 DILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGEN 613
            ||:||:||.|.||||:|:.|||..||||||||:|||||:.||.||.|||||||.||:.|||.|.:
  Rat   838 DIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGAD 902

  Fly   614 TTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HK 677
            |||:|||:||||||||||||||.||:::||||||:|:||.:||:.||||||.|..:|..... :.
  Rat   903 TTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVEAYFPGYN 967

  Fly   678 MHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKT 742
            ..:.:...|:.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||||.
  Rat   968 RSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKV 1032

  Fly   743 VVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGAT 807
            ||||||||||||||:.::|.:.|.:...|..:.|.|||.||.|||||:.:|:..:.|..|:
  Rat  1033 VVFDKTGTITHGTPVVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCKQELD---- 1093

  Fly   808 PQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEH 872
              ..:.|..:.||.||||||...|:|.|..|.::                   ::.::     |:
  Rat  1094 --TETLGTCTDFQVVPGCGISCKVTNIEGLLHKS-------------------NLKIE-----EN 1132

  Fly   873 LLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKI---IDSPEILVLIGNREWMERNAIEVPLE 934
            .:...|:.:...:|.|.       .|...::.|..:   :::.:..|||||||||.||.:.:..:
  Rat  1133 NIKNASLVQIDAINEQS-------SPSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISND 1190

  Fly   935 ISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAAS 999
            :.:.|...||:|.||||..::.:|..:.|::|.|||||.|||:.||.||::|||:||||..||.|
  Rat  1191 VDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARS 1255

  Fly  1000 IAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEA 1064
            ||.:|||..|:|||||||||||::::|..|.||||||||:|||||||.|.|||.|..|||||.||
  Rat  1256 IASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMASVGIAIGTGTDVAIEA 1320

  Fly  1065 SDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAM 1129
            :|:||:|||||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.||
  Rat  1321 ADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLIGIPIAAGVFLPIGLVLQPWMGSAAM 1385

  Fly  1130 AASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMP 1194
            ||||||||.|||.||:|||||..     .||.:..:.....|..|   :|:|.|:||.
  Rat  1386 AASSVSVVLSSLFLKLYRKPTYD-----NYELRPRSHTGQRSPSE---ISVHVGIDDT------- 1435

  Fly  1195 FKRSS--TSLISRIFMHDYGNITS--PDAKYGEGLLDPEEQYDGRTKIVRSRFHANDSTEL 1251
             .|:|  ..|:.||..:...:|.|  .|.:....::..|..   :..::...|..:|.|.|
  Rat  1436 -SRNSPRLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPD---KHSLLVGDFREDDDTTL 1492

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.