Protein Alignment ATP7 and ATP7

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_061516829.1
• Gene: ATP7 / 1280886
• VectorBaseID: AGAMI1_004933
• Length: 1303
• Species: Anopheles gambiae
• Alignment Length: 1287
• Identity: 803/1287 - (62%)
• Similarity: 980/1287 - (76%)
• Gaps: 76/1287 - (5%)

  Fly     7 VEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDID 71
            :|..:::|||||:|||||||||||...||.|.|::.:.|:|.|||||.||||..||||::|:|||
Mosquito    54 LEQPVASVRLPIIGMTCQSCVRNIEGTIGSKLGVIKINVVLAENAGYIDYDPSLTDPAQLAADID 118

  Fly    72 DMGFECSY--PGDAADPPETPA--------SAWTN---------IRVVGMTCQSCVRNIEGNIGT 117
            ||||||:|  ||.::..|:...        |..||         |.:.|||||||||||||||..
Mosquito   119 DMGFECTYTEPGASSAGPKRSILVEGVESDSETTNQKSDVRTTRISIEGMTCQSCVRNIEGNIKD 183

  Fly   118 KPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEAS-VQEPRSPSQSPS-PAPASSPKK 180
            :||:.||.|.|..:...|:||..|.....|||.||||||||. |.||..|.|..: .:|.::.||
Mosquito   184 RPGVISIRVLLDERLGIVEYDGRQTTAEAIAEQIDDMGFEARVVGEPNQPEQQRARSSPQANDKK 248

  Fly   181 RATPTPPPPSYAQNGSAVAIPV----EQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILV 241
            .||          |||..  |.    |...|.:||||::||||||||:||||||:||||::|||:
Mosquito   249 HAT----------NGSLT--PKKKADESAQLRRCFLHVQGMTCASCVSAIEKHCRKIYGVESILI 301

  Fly   242 ALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHV 306
            ||||||||||::..:.|..::||||||||||||:::||..||.:||:||:||||.|||.|||...
Mosquito   302 ALLAAKAEVKYDERLTTPADVAKSITELGFPTEVLEEPGTGETDVEIEILGMTCGSCVAKIEQTA 366

  Fly   307 LKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRK 371
            |||.||..|||.|..|||:|::..|.||.|:||||||.|||..::::|:||||||||||||||||
Mosquito   367 LKIPGVLQASVALTLKRGRFKFNNERTGARTICEAIEGLGFATRVLSGKDKMAHNYLEHKEEIRK 431

  Fly   372 WRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCLVPGLSMENLVMFLLSTPVQFFGGFHFYV 436
            |||||||||:||||||:||:|||:.|.::.|..|||::||||:|||:||.|||||||.||:|||:
Mosquito   432 WRNAFLVSLVFGGPCMIAMVYFMVLMHERSHEEMCCVLPGLSLENLIMFTLSTPVQFVGGWHFYI 496

  Fly   437 QSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLE 501
            |:|||:|||.:||||||:|.||:||:|||.|::||::|||::||||||||||||.||||||||:|
Mosquito   497 QAYRAVKHGASNMDVLITMATTVSYLYSVGVLVAAMVLEQHTSPLTFFDTPPMLFIFISLGRWME 561

  Fly   502 HIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVL 566
            |||||||||||||||||||.:|.||.:.||:.::||||||||.|||||||||:||:|||||||:|
Mosquito   562 HIAKGKTSEALSKLLSLKATEATLVTLGPDYAVLSEKVISVDLVQRGDILKVVPGSKVPVDGKIL 626

  Fly   567 YGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKA 631
            .|:|:|||||||||||||.|:||:|||||||||||:||::||||||:|||||||:||||||||||
Mosquito   627 CGNSTCDESLITGESMPVPKKKGAVVIGGSINQNGLLLMQATHTGEHTTLAQIVKLVEEAQTSKA 691

  Fly   632 PIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALS 696
            ||||||||||||||||||.||.|||:.||:.|:.:...:|.:...|..:..:.|||||||:||||
Mosquito   692 PIQQLADRIAGYFVPFVVAVSVITLVGWIVSGYIDIGHIPASDRDKEGLTPSEIIVSYAFRCALS 756

  Fly   697 VLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKV 761
            ||||||||||||||||||||:||.||::|:|||||..|||||||||:|||||||||||.||||::
Mosquito   757 VLAIACPCALGLATPTAVMVSTGVGALHGILVKGAGPLENAHKVKTIVFDKTGTITHGMPMTSRI 821

  Fly   762 TLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCG 826
            .:.|...||||||||||||:||.|||||||:|||.:.|:.|.:      ..||:.|:|.||||||
Mosquito   822 CMLVKPAVCSLARALTIVGSAEVNSEHPIATAIVKYVKETLEI------DGFGRCSNFSAVPGCG 880

  Fly   827 IRVTVSNYEQTLRQACNADRIINYENLHRT---HPQGSVPVDNGASIEHLLPQRSVRKSMELNNQ 888
            ||..:||...||.:...::::.||:|.:|:   |.|..:.: |||.:|.|:||.|..:...:..|
Mosquito   881 IRCVISNVGDTLNRVQQSEKMRNYQNSYRSEQQHQQQPLFM-NGAVVEELIPQLSASQKNTIELQ 944

  Fly   889 QLLSDLVLEPEEE--------LLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERK 945
            |||.   |||..|        ..:.:...|..|..|||||||||.||||.||.|::..|:.||:.
Mosquito   945 QLLH---LEPIGEGPDGTGGDAGSGEAFADVNEYNVLIGNREWMARNAIVVPPEVNIRMSEEEQM 1006

  Fly   946 GHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRTVY 1010
            ||||:|||:|||||||.:|||||||||||||||||||||:|:|||||||||||||||:|||..|:
Mosquito  1007 GHTAILCAMNGQLVCMLSVSDMVKPEAHLAVYTLKRMGIEVILLTGDNKNTAASIARQVGINRVF 1071

  Fly  1011 AEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLL 1075
            ||||||||||||||||..|:||||||||||||||||||||||.||:||||||||:|:||||||||
Mosquito  1072 AEVLPSHKVAKIQRIQEMGMRVAMVGDGVNDSPALAQADVGIAIASGTDVAAEAADVVLMRNDLL 1136

  Fly  1076 DVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSS 1140
            ||||||||||.|||:|..||.|||||||||||||:|:|.|:||||.|||||.|||||||||||||
Mosquito  1137 DVVACLDLSRKTVRKIHLNFLFASMYNLLGIPLAAGIFTPFGFTLEPWMASAAMAASSVSVVCSS 1201

  Fly  1141 LLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMPFKRSSTSLISR 1205
            |::|:|:|||..:|:|.||...:.|    |:..:.|.:|:||||||:|   |....||::|.:::
Mosquito  1202 LMIKLYKKPTQASLQTPEYVELMEA----GAFLDPDTISVHRGLDDIP---RPNLARSTSSTLAK 1259

  Fly  1206 IFMHDYGNITSPDAKYGEGL---LDPEEQYDGRTKIVRSRFHANDSTELQKL 1254
            :|  ..|..|..|     ||   ||.:|...|..|...:..: .|:||||||
Mosquito  1260 LF--GRGKDTKED-----GLLATLDDDEFSVGIVKTSNASIY-KDATELQKL 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020	42/64 (66%)
		HMA	97..159	CDD:238219	36/61 (59%)
		chaper_CopZ_Eh	212..276	CDD:411374	46/63 (73%)
		HMA	287..350	CDD:238219	39/62 (63%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	529/764 (69%)
ATP7	XP_061516829.1	None