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Protein Alignment ATP7 and Atp7a

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001103227.1	Gene:	Atp7a / 11977	MGIID:	99400	Length:	1492	Species:	Mus musculus

Alignment Length:	1296	Identity:	578/1296 - (44%)
Similarity:	791/1296 - (61%)	Gaps:	123/1296 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARI 66
            |||       ||....|.||.|:|||.||...:.....:..:.|.||..:....|:.....|..:
Mouse   274 PSD-------STTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEML 331

  Fly    67 ASDIDDMG---FECSYPGDAADPPETPASAWTN----------------IRVVGMTCQSCVRNIE 112
            ...|:.:.   :..|...:......:|:|:...                |.:.||||.|||::||
Mouse   332 RKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIE 396

  Fly   113 GNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASS 177
            |.|..|||:.||.|.||.....:::||....|..:.|.|:||||:|::     |:....|....:
Mouse   397 GVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAAL-----PADMKEPLVVIA 456

  Fly   178 PKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVA 242
            .....||..|..:..:|       |...:..||::.:.|||||||||.||::.::..|:.|:|||
Mouse   457 QPSLETPLLPSSNELEN-------VMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVA 514

  Fly   243 LLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVL 307
            |:|.||||::|..|:....||:.|.||||...:::....|...:||.:.||||||||:||||.:.
Mouse   515 LMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGILELVVRGMTCASCVHKIESTLT 579

  Fly   308 KIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKW 372
            |.:|:...||.|.|.:...:|..|..|||.|...|.:|||||.|:. :|:.| |:|:||.||::|
Mouse   580 KHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVK-KDRSA-NHLDHKREIKQW 642

  Fly   373 RNAFLVSLIFGGPCMVAMIYFML------------EMSDKGHANMCC-------LVPGLSMENLV 418
            |.:|||||.|..|.|..|:|.|:            .||::...||..       ::||||:.||:
Mouse   643 RGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQNMSNEEMINMHSAMFLERQILPGLSIMNLL 707

  Fly   419 MFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTF 483
            ..||..||||.||::||:|:|:|:||.|.||||||.:.|||::.||:.:::.|:......:|:||
Mouse   708 SLLLCLPVQFCGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLVILLVAMFERAKVNPITF 772

  Fly   484 FDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRG 548
            |||||||.:||:|||||||||||||||||:||:||:|.:|.:|.::.:..::||:.:.|:.||||
Mouse   773 FDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRG 837

  Fly   549 DILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGEN 613
            ||:||:||.|.||||:|:.|||..||||||||:|||||:.||.||.|||||||.||:.|||.|.:
Mouse   838 DIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGAD 902

  Fly   614 TTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HK 677
            |||:|||:||||||||||||||.||:::||||||:|:||.:||:.||||||.|..:|..... :.
Mouse   903 TTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYN 967

  Fly   678 MHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKT 742
            ..:.:...|:.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||||.
Mouse   968 RSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKV 1032

  Fly   743 VVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGAT 807
            ||||||||||||||:.::|.:.|.:...|..:.|.|||.||.|||||:.:|:..:.|..|:
Mouse  1033 VVFDKTGTITHGTPVVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCKKELD---- 1093

  Fly   808 PQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTH---PQGSVPVDNGAS 869
              ..:.|..:.||.||||||...|:|.|..               ||:::   .:.::...:...
Mouse  1094 --TETLGTCTDFQVVPGCGISCKVTNIEGL---------------LHKSNLKIEENNIKNASLVQ 1141

  Fly   870 IEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLE 934
            |:.:..|.|...||.::..  ||:.|              ::.:..|||||||||.||.:.:..:
Mouse  1142 IDAINEQSSTSSSMIIDAH--LSNAV--------------NTQQYKVLIGNREWMIRNGLVISND 1190

  Fly   935 ISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAAS 999
            :.:.|...||:|.||||..::.:|..:.|::|.|||||.|||:.||.||::|||:||||..||.|
Mouse  1191 VDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARS 1255

  Fly  1000 IAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEA 1064
            ||.:|||..|:|||||||||||::::|..|.||||||||:|||||||.|:|||.|..|||||.||
Mouse  1256 IASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEA 1320

  Fly  1065 SDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAM 1129
            :|:||:|||||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.||
Mouse  1321 ADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAM 1385

  Fly  1130 AASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMP 1194
            ||||||||.|||.||:|||||..     .||....:.....|..|   :|:|.|:||.
Mouse  1386 AASSVSVVLSSLFLKLYRKPTYD-----NYELHPRSHTGQRSPSE---ISVHVGIDDT------- 1435

  Fly  1195 FKRSS--TSLISRIFMHDYGNITS--PDAKYGEGLLDPEEQYDGRTKIVRSRFHANDSTEL 1251
             .|:|  ..|:.||..:...:|.|  .|.:....::..|..   :..::...|..:|.|.|
Mouse  1436 -SRNSPRLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPD---KHSLLVGDFREDDDTTL 1492

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.