Protein Alignment ATP7 and atp7b

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_002936778.3
• Gene: atp7b / 100497797
• XenbaseID: XB-GENE-6044681
• Length: 1467
• Species: Xenopus tropicalis
• Alignment Length: 1426
• Identity: 599/1426 - (42%)
• Similarity: 788/1426 - (55%)
• Gaps: 313/1426 - (21%)

  Fly     1 MPSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPAR 65
            :|.|      :.:|.:.|.||||||||::|...|.:.||::|:.|.||:|....:|...:..|.:
 Frog    72 LPDD------VGSVVVAIQGMTCQSCVQSIEGRISKVSGVVGINVCLEQNNAIVNYLQTEITPHK 130

  Fly    66 IASDIDDMGFECSYPGDAADPPETPASAW----TNIRVVGMTCQSCVRNIEGNIG---------- 116
            |..:|:||||:.|....:..|....:|.:    ..|||.||||||||..|||.||
 Frog   131 ICEEIEDMGFDASLSEQSGMPSSVKSSYYGDNVIKIRVEGMTCQSCVNTIEGKIGKIQGVQKIKV 195

  Fly   117 -----------------------------------TKP--------------------------- 119
                                               .||
 Frog   196 SLTGQEAVITYQSHIIQAEDLRKYIEDMGFEASIKNKPDPTKLGTIDIERLQNSIAENHSGHTNS 260

  Fly   120 ---------------------------GIHSIEVQLAAKNA------------------------ 133
                                       ||.||.|.|..|||
 Frog   261 NTVTLGIDGMRCKSCVHNIEGYVSGLAGIQSIRVSLKNKNAVVCLSQGSTSLLSLKESIENLPPG 325

  Fly   134 ----------------------------------------------------------------- 133
                                                                             
 Frog   326 KFKVTLPVGVEKGQSLARNSTHSSHRDQSMGGNMAIISIGGMTCQSCVSSIENMISQRKGVLHIL 390

  Fly   134 --------RVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPS 190
                    .:.|:|.:.:..::...|:||||.:::....|||.|.|  ..:|.::....|||..:
 Frog   391 VSLDEGNGNIFYNPCETNAEELRAAIEDMGFHSTLVSDNSPSISCS--EYNSKEEENKQTPPKAT 453

  Fly   191 YAQNGS----AVAIPVEQE----------LLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILV 241
            ...:||    ...:|.:..          ...||||.|.||||||||:.||::.||..|:.|:||
 Frog   454 RQISGSRDYILDVLPKKSHPDFANEKYDTAPEKCFLQITGMTCASCVSNIERNLKKKDGIVSVLV 518

  Fly   242 ALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHV 306
            ||::.||||||..:.:....||:.:.:|||...::::....:..|||.|.||||||||:.|||.:
 Frog   519 ALMSGKAEVKFYPDRIEPLEIAQLVEDLGFGASVMEDYTASDGNVELIITGMTCASCVHNIESRL 583

  Fly   307 LKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRK 371
            ::..|:..|||.|.|.:.:.::..|..|||.|...||.:||:|.| ..||..||. |:|||||::
 Frog   584 MRTPGILQASVALATCKAQVKFDPEIVGPRDIIRIIEGIGFQASL-AKRDPTAHK-LDHKEEIKQ 646

  Fly   372 WRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCL----VPGLSMENLVMFLLSTPVQFFGGF 432
            |||:||.||:||.|.::.|||.:  .::|.|.|...|    |||||:.|||.|:|.|.||..||.
 Frog   647 WRNSFLFSLLFGIPVIILMIYML--AANKDHHNTMVLDRNIVPGLSIINLVFFILCTFVQTLGGR 709

  Fly   433 HFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLG 497
            :||||:|:::||..|||||||.:.|||:|:|||.::..|::.:.:.||.|||||||||.:||:||
 Frog   710 YFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVILTVAMVEKADKSPETFFDTPPMLFMFIALG 774

  Fly   498 RWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVD 562
            ||||||||.||||||:||:||:|.:|.:|....:..|:.|:.::|:.||||||:||:||.|.|||
 Frog   775 RWLEHIAKSKTSEALAKLISLQATEAAVVTFGANQIILREEQVAVELVQRGDIVKVVPGGKFPVD 839

  Fly   563 GKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQ 627
            |||:.|.|..||||||||.|||.|:.||:||.||||.:|.:||||||.|..|||||||:||||||
 Frog   840 GKVIEGTSMADESLITGEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQIVKLVEEAQ 904

  Fly   628 TSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLV----PVAMEHKMHMDQNTIIVS 688
            .||||||||||:|:||||||::::|.:||:.||||||.|.:::    |   .:..::.:..:|:.
 Frog   905 MSKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFDIIIKYFP---SYSKNISKTEVIIR 966

  Fly   689 YAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITH 753
            .||:.:::||:|||||||||||||||||.||..|.||:|:||...||.|||:|.|:|||||||||
 Frog   967 VAFQTSITVLSIACPCALGLATPTAVMVGTGVAAQNGILIKGGEPLEMAHKIKAVMFDKTGTITH 1031

  Fly   754 GTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSH 818
            |.|...:|.|........|.|.|.:||.||.:||||:..|:..:.|:.|....      .|..:.
 Frog  1032 GVPKVMRVLLLGDVVKMPLKRMLAVVGTAEASSEHPLGMAVTKYCKEELGTEL------LGYCTD 1090

  Fly   819 FQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSM 883
            |||||||||...|:|.|..|.|        |.|.|:.                    |.|.|.|
 Frog  1091 FQAVPGCGISCKVNNIESVLVQ--------NEEGLNE--------------------QNSYRNS- 1126

  Fly   884 ELNNQQLLSDLVLEPEEELLTDQKIIDSPEIL---------VLIGNREWMERNAIEVPLEISDCM 939
                  |:.          .||..:|.:||:|         |||||||||.||.:.:..::.:.|
 Frog  1127 ------LIG----------TTDSSLIITPELLGAQAPLAHTVLIGNREWMRRNGLHISTDVDEAM 1175

  Fly   940 THEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREV 1004
            :..|.||.||||.|::|:|..|.|::|.||.||.|||:|||.|||||||:||||:.||.:||.:|
 Frog  1176 SSHEMKGQTAVLVAIDGELCGMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKAIATQV 1240

  Fly  1005 GIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVL 1069
            ||:.|:|||||||||||:|.:|::..||||||||||||||||:|||||.|..|||||.||:||||
 Frog  1241 GIKKVFAEVLPSHKVAKVQALQSDNKRVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADIVL 1305

  Fly  1070 MRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSV 1134
            :|||||||||.:.||:.||||||.||.||.:|||||||:|:|:|.|.|..|.|||.|.|||||||
 Frog  1306 IRNDLLDVVASIHLSKRTVRRIRLNFVFALIYNLLGIPIAAGVFMPAGLVLQPWMGSAAMAASSV 1370

  Fly  1135 SVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDEL--DKLSLHRGLD----DLPE 1189
            |||.|||.||.||||.:.     .|||     ||.|....|  .::|:|.|:|    |||:
 Frog  1371 SVVLSSLQLKCYRKPDSD-----RYEA-----RAQGHMKPLTPSQISVHIGMDDRWRDLPK 1421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020	26/64 (41%)
		HMA	97..159	CDD:238219	34/257 (13%)
		chaper_CopZ_Eh	212..276	CDD:411374	31/63 (49%)
		HMA	287..350	CDD:238219	29/62 (47%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	410/770 (53%)
atp7b	XP_002936778.3	HMA	80..143	CDD:238219	26/62 (42%)
		HMA	165..228	CDD:238219	16/62 (26%)
		HMA	264..322	CDD:238219	9/57 (16%)
		HMA	362..424	CDD:238219	7/61 (11%)
		HMA	489..551	CDD:238219	31/61 (51%)
		HMA	564..627	CDD:238219	29/62 (47%)
		P-type_ATPase_Cu-like	649..1360	CDD:319783	407/766 (53%)