DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and atp7b

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_002936778.3	Gene:	atp7b / 100497797	XenbaseID:	XB-GENE-6044681	Length:	1467	Species:	Xenopus tropicalis

Alignment Length:	1426	Identity:	599/1426 - (42%)
Similarity:	788/1426 - (55%)	Gaps:	313/1426 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPAR 65
            :|.|      :.:|.:.|.||||||||::|...|.:.||::|:.|.||:|....:|...:..|.:
Frog    72 LPDD------VGSVVVAIQGMTCQSCVQSIEGRISKVSGVVGINVCLEQNNAIVNYLQTEITPHK 130

  Fly    66 IASDIDDMGFECSYPGDAADPPETPASAW----TNIRVVGMTCQSCVRNIEGNIG---------- 116
            |..:|:||||:.|....:..|....:|.:    ..|||.||||||||..|||.||
Frog   131 ICEEIEDMGFDASLSEQSGMPSSVKSSYYGDNVIKIRVEGMTCQSCVNTIEGKIGKIQGVQKIKV 195

  Fly   117 -----------------------------------TKP--------------------------- 119
                                               .||
Frog   196 SLTGQEAVITYQSHIIQAEDLRKYIEDMGFEASIKNKPDPTKLGTIDIERLQNSIAENHSGHTNS 260

  Fly   120 ---------------------------GIHSIEVQLAAKNA------------------------ 133
                                       ||.||.|.|..|||
Frog   261 NTVTLGIDGMRCKSCVHNIEGYVSGLAGIQSIRVSLKNKNAVVCLSQGSTSLLSLKESIENLPPG 325

  Fly   134 ----------------------------------------------------------------- 133

Frog   326 KFKVTLPVGVEKGQSLARNSTHSSHRDQSMGGNMAIISIGGMTCQSCVSSIENMISQRKGVLHIL 390

  Fly   134 --------RVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPS 190
                    .:.|:|.:.:..::...|:||||.:::....|||.|.|  ..:|.::....|||..:
Frog   391 VSLDEGNGNIFYNPCETNAEELRAAIEDMGFHSTLVSDNSPSISCS--EYNSKEEENKQTPPKAT 453

  Fly   191 YAQNGS----AVAIPVEQE----------LLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILV 241
            ...:||    ...:|.:..          ...||||.|.||||||||:.||::.||..|:.|:||
Frog   454 RQISGSRDYILDVLPKKSHPDFANEKYDTAPEKCFLQITGMTCASCVSNIERNLKKKDGIVSVLV 518

  Fly   242 ALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHV 306
            ||::.||||||..:.:....||:.:.:|||...::::....:..|||.|.||||||||:.|||.:
Frog   519 ALMSGKAEVKFYPDRIEPLEIAQLVEDLGFGASVMEDYTASDGNVELIITGMTCASCVHNIESRL 583

  Fly   307 LKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRK 371
            ::..|:..|||.|.|.:.:.::..|..|||.|...||.:||:|.| ..||..||. |:|||||::
Frog   584 MRTPGILQASVALATCKAQVKFDPEIVGPRDIIRIIEGIGFQASL-AKRDPTAHK-LDHKEEIKQ 646

  Fly   372 WRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCCL----VPGLSMENLVMFLLSTPVQFFGGF 432
            |||:||.||:||.|.::.|||.:  .::|.|.|...|    |||||:.|||.|:|.|.||..||.
Frog   647 WRNSFLFSLLFGIPVIILMIYML--AANKDHHNTMVLDRNIVPGLSIINLVFFILCTFVQTLGGR 709

  Fly   433 HFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLG 497
            :||||:|:::||..|||||||.:.|||:|:|||.::..|::.:.:.||.|||||||||.:||:||
Frog   710 YFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVILTVAMVEKADKSPETFFDTPPMLFMFIALG 774

  Fly   498 RWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVD 562
            ||||||||.||||||:||:||:|.:|.:|....:..|:.|:.::|:.||||||:||:||.|.|||
Frog   775 RWLEHIAKSKTSEALAKLISLQATEAAVVTFGANQIILREEQVAVELVQRGDIVKVVPGGKFPVD 839

  Fly   563 GKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQ 627
            |||:.|.|..||||||||.|||.|:.||:||.||||.:|.:||||||.|..|||||||:||||||
Frog   840 GKVIEGTSMADESLITGEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQIVKLVEEAQ 904

  Fly   628 TSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLV----PVAMEHKMHMDQNTIIVS 688
            .||||||||||:|:||||||::::|.:||:.||||||.|.:::    |   .:..::.:..:|:.
Frog   905 MSKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFDIIIKYFP---SYSKNISKTEVIIR 966

  Fly   689 YAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITH 753
            .||:.:::||:|||||||||||||||||.||..|.||:|:||...||.|||:|.|:|||||||||
Frog   967 VAFQTSITVLSIACPCALGLATPTAVMVGTGVAAQNGILIKGGEPLEMAHKIKAVMFDKTGTITH 1031

  Fly   754 GTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSH 818
            |.|...:|.|........|.|.|.:||.||.:||||:..|:..:.|:.|....      .|..:.
Frog  1032 GVPKVMRVLLLGDVVKMPLKRMLAVVGTAEASSEHPLGMAVTKYCKEELGTEL------LGYCTD 1090

  Fly   819 FQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRSVRKSM 883
            |||||||||...|:|.|..|.|        |.|.|:.                    |.|.|.|
Frog  1091 FQAVPGCGISCKVNNIESVLVQ--------NEEGLNE--------------------QNSYRNS- 1126

  Fly   884 ELNNQQLLSDLVLEPEEELLTDQKIIDSPEIL---------VLIGNREWMERNAIEVPLEISDCM 939
                  |:.          .||..:|.:||:|         |||||||||.||.:.:..::.:.|
Frog  1127 ------LIG----------TTDSSLIITPELLGAQAPLAHTVLIGNREWMRRNGLHISTDVDEAM 1175

  Fly   940 THEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREV 1004
            :..|.||.||||.|::|:|..|.|::|.||.||.|||:|||.|||||||:||||:.||.:||.:|
Frog  1176 SSHEMKGQTAVLVAIDGELCGMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKAIATQV 1240

  Fly  1005 GIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVL 1069
            ||:.|:|||||||||||:|.:|::..||||||||||||||||:|||||.|..|||||.||:||||
Frog  1241 GIKKVFAEVLPSHKVAKVQALQSDNKRVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADIVL 1305

  Fly  1070 MRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSV 1134
            :|||||||||.:.||:.||||||.||.||.:|||||||:|:|:|.|.|..|.|||.|.|||||||
Frog  1306 IRNDLLDVVASIHLSKRTVRRIRLNFVFALIYNLLGIPIAAGVFMPAGLVLQPWMGSAAMAASSV 1370

  Fly  1135 SVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDEL--DKLSLHRGLD----DLPE 1189
            |||.|||.||.||||.:.     .|||     ||.|....|  .::|:|.|:|    |||:
Frog  1371 SVVLSSLQLKCYRKPDSD-----RYEA-----RAQGHMKPLTPSQISVHIGMDDRWRDLPK 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219	26/61 (43%)
		HMA	97..159	CDD:238219	34/257 (13%)
		HMA	214..274	CDD:238219	30/59 (51%)
		ZntA	285..1131	CDD:225127	456/862 (53%)
		HMA	287..350	CDD:238219	29/62 (47%)
		E1-E2_ATPase	489..735	CDD:278548	148/249 (59%)
		COG4087	<984..1085	CDD:226572	73/100 (73%)
atp7b	XP_002936778.3	HMA	80..143	CDD:238219	26/62 (42%)
		HMA	165..228	CDD:238219	16/62 (26%)
		HMA	264..322	CDD:238219	9/57 (16%)
		HMA	362..424	CDD:238219	7/61 (11%)
		HMA	489..551	CDD:238219	31/61 (51%)
		HMA	564..627	CDD:238219	29/62 (47%)
		P-type_ATPase_Cu-like	649..1360	CDD:319783	407/766 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1011	1.000	Inparanoid score	I291
OMA	1	1.010	-	-		QHG53773
OrthoDB	1	1.010	-	-		D33208at33208
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		otm49150
Panther	1	1.100	-	-	LDO	PTHR43520
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1231
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080