DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and atp7a

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001361526.1	Gene:	atp7a / 100170482	XenbaseID:	XB-GENE-1010489	Length:	1501	Species:	Xenopus tropicalis

Alignment Length:	1260	Identity:	586/1260 - (46%)
Similarity:	790/1260 - (62%)	Gaps:	134/1260 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMG---FE--- 76
            |.||.|:|||.||..:||.:.|:..:.|.||.......:....|....:...|:.:.   |:
Frog   281 IEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGTFKVSL 345

  Fly    77 CSYP-----------GDAADPPE---TPA-----SAWTNIRVVGMTCQSCVRNIEGNIGTKPGIH 122
            |::|           .:|:...|   :|:     |..|.|.:.||||.|||::|||.|..|||:.
Frog   346 CNHPELAETFSMQKNSEASCAKEIFSSPSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVK 410

  Fly   123 SIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASV-----QEPRSPSQSPSPAPASS--PKK 180
            ||:|.|...|..||||||...|..|...|:||||:||:     |.....|::......:|  ||:
Frog   411 SIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLANTGQADAFTSEASQKPFLNSLLPKE 475

  Fly   181 RA---TPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVA 242
            |.   ||....|             |:..:.|||:.|.|||||||||.||::.::..|:.|:|||
Frog   476 RTNKETPVHSKP-------------EKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVA 527

  Fly   243 LLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVL 307
            |:|.||||::|..|:....||:.|.||||...:::..|:|...:||.:.||||||||:||||.::
Frog   528 LMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCASCVHKIESRLM 592

  Fly   308 KIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKW 372
            |.:||..:||.|.|.:...::..|..|||.|.:.|..|||...|:. :|:.| ::|:|:.||::|
Frog   593 KTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVK-KDRSA-SHLDHRVEIQRW 655

  Fly   373 RNAFLVSLIFGGPCMVAMIYFM-------------LEMSD--KGHANMCC---LVPGLSMENLVM 419
            :.:||:||||..|.|..|::.|             :.|.|  ..|..|..   ::||||:.|||.
Frog   656 KRSFLISLIFCIPVMGLMVHMMFMENHYLMPHHHNMTMEDIASYHPTMVLEYQIIPGLSIMNLVS 720

  Fly   420 FLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFF 484
            .||..||||.||::||:|:|:|:||.|.||||||.:.|:::::||:.|:|.|:..:...:|:|||
Frog   721 LLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEKSKVNPITFF 785

  Fly   485 DTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGD 549
            ||||||.:||:||||||||||.|||||||:|:||:|.:|.:|.:.||..:.||:.:.|:.|||||
Frog   786 DTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQVDVELVQRGD 850

  Fly   550 ILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENT 614
            |::|.||.|.||||:|:.|.|..||||||||:|||:|:.||.||.|||||||.||:.|||.|.:|
Frog   851 IVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLIAATHVGSDT 915

  Fly   615 TLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKM 678
            ||:|||:|||:||||||||||.||:::||||||:|.||.:||..|||||:.|..:|..... :..
Frog   916 TLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEKYFPGYNK 980

  Fly   679 HMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTV 743
            .:.:..:||.:||:.|::||.|||||:|||||||||||.||.||.||:|:||...||.|||||||
Frog   981 SISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKTV 1045

  Fly   744 VFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATP 808
            |||||||||.|||:..:|.:.|.:......:.|.|||.||.|||||:.||::.:.|::||
Frog  1046 VFDKTGTITKGTPVVMQVKVLVESNRMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLN----- 1105

  Fly   809 QAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVD-NGASIEH 872
             |.:.|....|||||||||...|:|.|..|..|...|           :.:.:|.|. :|...:.
Frog  1106 -AETLGTCYDFQAVPGCGISCKVNNIEPLLHAANGPD-----------NKRNAVLVQIDGQHEDS 1158

  Fly   873 LLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSP--EILVLIGNREWMERNAIEVPLEI 935
            :||  |:..|...:|.                     .||  ...|||||||||.||.:.:..|.
Frog  1159 ILP--SITVSQNPSNG---------------------SSPPQTYSVLIGNREWMNRNFLTLTAET 1200

  Fly   936 SDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASI 1000
            ...||..|:||.||||.|::|.|..:.|::|.|||||.||:::|:.||:|:||:||||..||.:|
Frog  1201 DSLMTEHEKKGRTAVLVAVDGVLCGLIAIADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTI 1265

  Fly  1001 AREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEAS 1065
            |.:|||..|:|||||||||||::::|..|.||||||||:|||||||.|||||||.:|||||.||:
Frog  1266 AAQVGITKVFAEVLPSHKVAKVKQLQEQGTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAA 1330

  Fly  1066 DIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMA 1130
            |:||:|||||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.|||
Frog  1331 DVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMA 1395

  Fly  1131 ASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGS--EDELDKLSLHRGLDDLPEKGRM 1193
            |||||||.||||||:||||:.:.|.          :|..|.  :..|..:|:|.||.:
Frog  1396 ASSVSVVFSSLLLKLYRKPSREKLE----------QRVQGQMRQKSLSDISVHIGLTE------- 1443

  Fly  1194 PFKRSST--SLISRIFMHDYGNITS 1216
             .:|:||  .|:.||..:...::.|
Frog  1444 -NRRTSTKLDLLDRIVNYSRASLNS 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219	18/65 (28%)
		HMA	97..159	CDD:238219	33/61 (54%)
		HMA	214..274	CDD:238219	32/59 (54%)
		ZntA	285..1131	CDD:225127	446/867 (51%)
		HMA	287..350	CDD:238219	30/62 (48%)
		E1-E2_ATPase	489..735	CDD:278548	149/246 (61%)
		COG4087	<984..1085	CDD:226572	71/100 (71%)
atp7a	NP_001361526.1	HMA	12..74	CDD:238219
		HMA	172..234	CDD:238219
		HMA	279..336	CDD:238219	17/54 (31%)
		HMA	384..447	CDD:238219	33/62 (53%)
		HMA	497..559	CDD:238219	32/61 (52%)
		HMA	572..632	CDD:238219	28/59 (47%)
		P-type_ATPase_Cu-like	657..1389	CDD:319783	403/771 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1011	1.000	Inparanoid score	I291
OMA	1	1.010	-	-		QHG53773
OrthoDB	1	1.010	-	-		D649559at2759
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		otm49150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1231
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980