DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p24-1 and TMED7-TICAM2

DIOPT Version :9

Sequence 1:	NP_001259465.1	Gene:	p24-1 / 32140	FlyBaseID:	FBgn0030341	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_001157940.1	Gene:	TMED7-TICAM2 / 100302736	HGNCID:	33945	Length:	404	Species:	Homo sapiens

Alignment Length:	162	Identity:	85/162 - (52%)
Similarity:	106/162 - (65%)	Gaps:	0/162 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AVEFTFDLADNAVDCFYEEIKKNSSAYFEFQVSAGGQLDVDVTLKDPQGKVIYSLEKATFDSHQF 83
            |.|.||:|.|||..||||:|.:.:....||||..||..|||..|:||.|||:|...|..:||..|
Human    34 ASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTF 98

  Fly    84 VAETTGVYTACFGNQFSAFSHKIVYVDFQVGEEPALPGVDEHATVLTQMETSSQAIHKGLNDILD 148
            .|...|.|..||.|:||.|:||.||.||||||:|.|...:...:.|||||::..:||:.|..::|
Human    99 TASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVID 163

  Fly   149 AQTHHRLREAQGRKRAEDLNQRVMVWSSLETA 180
            .|||.||||||||.||||||.||..|.|::|:
Human   164 YQTHFRLREAQGRSRAEDLNTRVAYWHSVDTS 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p24-1	NP_001259465.1	EMP24_GP25L	21..197	CDD:279450	84/160 (53%)
TMED7-TICAM2	NP_001157940.1	EMP24_GP25L	36..189	CDD:279450	81/152 (53%)
TMED7-TICAM2	NP_001157940.1	TIR_2	250..>341	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150903
Domainoid	1	1.000	185	1.000	Domainoid score	I3391
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3849
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52485
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	1	1.000	-	-		otm41555
orthoMCL	1	0.900	-	-		OOG6_103696
Panther	1	1.100	-	-	LDO	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	1	1.000	-	-		X1789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790