DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28c1 and tbxas1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	541	Identity:	131/541 - (24%)
Similarity:	227/541 - (41%)	Gaps:	78/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTHSYVGCYLL 77
            |..:|.:.:|.|.:..|.|:..|:.||..|   |::..|..|.....|:...|.....|   |:.
Zfish    29 LSLLYWYSISPFSNLERCGIKHPKPLPFIG---NLMMFRNGFFKSQADLINKYGRICGY---YIG 87

  Fly    78 RAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAK---DRLVALNPFVLEGEEWRHQRAVFST 139
            |...:::.:|.::.::.|..|:.|.|...::  .|.|   |.|:     :|:||:|:..|::.:.
Zfish    88 RRSTVIIADPDMLRQVMVKEFNKFPNRMTAR--GITKPMSDSLI-----MLKGEQWKRVRSILTP 145

  Fly   140 LLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLD---CIDLGLRFTGESLFDCVLGIQARTFT 201
            ..:..:::....::......|.:.:...:......:   |...   ||.:.:.....|.|..:..
Zfish   146 TFSAAKMKEMVPLINTATETLLRNLKSHAESENSFNIHKCFGC---FTMDVIASVAFGTQVDSQN 207

  Fly   202 DNPLPVVRQNHEMSAEN--RGLAIAGAVHGLFPNLPRWLRPKVFPRSHDR---FYGQMISEALRL 261
            :...|.|.|..:..|.:  |.:.|   ....||.|.|.|...:..:|.|.   |:.|.|.:.::.
Zfish   208 NPDDPFVHQASKFFAFSFFRPIMI---FFMAFPFLLRLLAGLLPNKSRDEMNSFFTQCIQKMIKQ 269

  Fly   262 R--RSKHQERNDFINHLLEM--------------------------------------QRELDLS 286
            |  .|..|.|.||:..:|::                                      |::..::
Zfish   270 RDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKRSQQKRMMT 334

  Fly   287 EEDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYL 351
            |:::...:..|:..|.:|:||::|....||..:|:||::|.||:..........|...:.:|.||
Zfish   335 EDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHETVDYANVQELKYL 399

  Fly   352 SACFNESLRIYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFR 416
            .....||||:||.....::...::..|.|..      |..|..:.:|...||.||:.:.||..|.
Zfish   400 DMVICESLRLYPPAFRVARDVEEDTVLNGQF------LPKGASLEIPTGFLHYDPEHWTEPTKFI 458

  Fly   417 PERFLDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDP 481
            ||||.... |..:...::|.||.|||.||||||.....|.||..|.:||.|:....|....||..
Zfish   459 PERFTPEA-KARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTEIPLELKS 522

  Fly   482 LIFVGVHKGGIWLQFVPRKNV 502
            ...:| .|.|:.::...|:|:
Zfish   523 HTTLG-PKNGVMVKITERENL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	120/502 (24%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	123/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820